@CombineLab@mas.to The COMputational Biology in Imaging geNEtics lab at @UCL, led by Dr Andre Altmann. Passionate about brains, genetics, and good coffee.
London, England
Joined October 2018
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COMBINE Lab@UCL retweeted
4 yr fully-funded PhD* to understand how dementia causes 'brainsight' loss in the largest imaging-genetics study (UK Biobank) & posterior cortical atrophy (visual variant Alzheimer's):
tinyurl.com/te9snjdx
* @EPSRC * @BrainAppeal
@drcionucl
@RareDementia
@UCLIoN
@CombineLab
COMBINE Lab@UCL retweeted
Latest paper out of the @EDADS_jpnd project led by us at @CMICUCL is about Alzheimer's disease-sensitive harmonisation, improving on Combat and Neuroharmony (which can erase disease signal). doi.org/10.1148/ryai.240030
FAO: Quantitative Neuroradiology enthusiasts
COMBINE Lab@UCL retweeted
HOW DOES YOUR GENETIC CODE affect your brain? 💡A new genetic roadmap of the brain (in today's Nature Genetics) reports:
💡100s of genomic loci affect deep brain structures
💡Genetic variants driving brain volume overlap with risk loci for Parkinson's, ADHD, many brain diseases
⚡️Studied N=74,898 people scanned with MRI + GWAS !
⚡️⚡️Polygenic scores now account for up to 10% of the regional brain volume variation in held-out, independent samples not used for discovery; modeling this variance should help future studies
👉👉PDF: nature.com/articles/s41588-0…
🎈Kudos to Luis García-Marín*, Adrian Campos* + @sudha_md @Frutiloopz @WiroNiessen @jsteinlab @njahanshad @lishenlc @amarquand @mallarchkrvrty1 @StefanEhrlich3 @Roshchupkin @ASaykin @_MariekeKlein_ @AvramHolmes @BFranke_lab @lianne_schmaal @jorsmo @lemaitreh_alien @vdcalhoun + 189 researchers worldwide collaborating for 7 years to do this ! @enigmabrains @chargetiger @uk_biobank ABCD + many more ... 🎈
*co-1st authors
COMBINE Lab@UCL retweeted
In this week’s podcast episode, Stanford neurologist Michael Greicius discusses the promising future for Alzheimer’s therapies despite skepticism toward the effectiveness of new treatments that target amyloid plaques. #alzheimers #neuroscience
🔗neuroscience.stanford.edu/ne…
ALT From Our Neurons to Yours; Wu Tsai Neurosciences Institute, Stanford University
ALT Michael Greicius, Iqbal Farrukh and Asad Jamal Professor of Neurology and Neurological Sciences
COMBINE Lab@UCL retweeted
Come on in and join us ! @KonradWagstyl and I have a fully-funded 4 yr PhD-ship open thru the super NIMH-UCL (D.C/London) graduate program partnership (shorturl.at/Qr5uq). Bridge Macro<-> views of 🧠 wt neuroimaging & omics (e.g. shorturl.at/W2cgo). Pls DM/apply ! 😃
COMBINE Lab@UCL retweeted
Disentangling genetic risks for development and progression of Alzheimer’s disease
New scientific commentary by Niklas Mattsson-Carlgren tinyurl.com/4p5shuwp
COMBINE Lab@UCL retweeted
Earlier this month @TheLancet Commission led by Prof @Gill_Livingston (@UCLPsychiatry) found that nearly half of #dementia cases could be prevented or delayed by tackling 14 modifiable health & lifestyle factors through our lives: bit.ly/4fkUwuy
COMBINE Lab@UCL retweeted
AI’s promise in ophthalmology is immense, from handling patient backlogs to improving care. But success hinges on creating the right ecosystem. Professor @pearsekeane, @UCLeye shares his perspective in @OphthoMag.
bit.ly/3yayBWn
COMBINE Lab@UCL retweeted
The figure we all have to learn by heart: The updated Lancet Commission on potentially modifiable risk factors for dementia. #AAIC24
COMBINE Lab@UCL retweeted
More than 100 neuroimaging researchers, including @furranko, @demwassermann, @memartone, have signed a statement for the leadership of @uk_biobank —in protest of a switch from a data-download to cloud-only access model.
By @callimcflurry
bit.ly/4d24501
COMBINE Lab@UCL retweeted
Estarellas et al. report that an adapted Subtype and Stage Inference algorithm accommodates missing data in multimodal #Alzheimersdisease studies. @mar_estarellas @UCLMIGPOND @NeilOxtoby @jmschott @fishpiechicken @YoungAlexL
edin.ac/3SjesUI
COMBINE Lab@UCL retweeted
So thrilled to see our Imaging-genetics paper finally out in A&D!! And even more that this is happening during an amazing AAIC, were we first presented these results last year.
... 🎈
alz-journals.onlinelibrary.w…
COMBINE Lab@UCL retweeted
🚨I'm delighted to share a new publication from the #BettencourtLab team by @megha7murthy et al. on a cross-comparative investigation of #brain #DNAmethylation patterns in #MSA, #PD, #PSP.
doi.org/10.1007/s00401-024-0….
Thank you to all involved🙏!
@UCLIoN @MSAtrust #epigenetics
COMBINE Lab@UCL retweeted
Delighted to introduce Professor Sir John Hardy as Vice President of @AlzResearchUK John is a shining light in our field & long time supporter.
Do join me in welcoming him by reading my blog #ForACure alzheimersresearchuk.org/new…
COMBINE Lab@UCL retweeted
ENIGMA @OHBM Party tonight in Seoul, Korea !
Thanks to the hotel for putting up with 100 of us showing up at their rooftop bar :)
[1] Drone videos courtesy of Andrei Irimia
[2] 1000 thanks Gaon Kim, Sophia Thomopoulos for organising another great event)
@enigmabrains @AddictionEnigma @enigma_bipolar
#OHBM2024
COMBINE Lab@UCL retweeted
So basically it will take minimum five years to produce a document that no one will read or cite?
#academicchatter
COMBINE Lab@UCL retweeted
Our machine learning pipeline to analyze dissection photos is finally published in @eLife.
-Paper: elifesciences.org/articles/9…
-Implementation in @FreeSurferMRI : surfer.nmr.mgh.harvard.edu/f…
-Video: youtube.com/watch?v=wo5meYRa…
Work with @HTregidgo @therelaxationt1 @AdrianDalca
& many others
COMBINE Lab@UCL retweeted
Altmann et al. use survival analysis to examine whether genetic risk for Alzheimer’s disease contributes equally to transition between all ATN stages, or whether it instead exhibits stage-dependent effects. tinyurl.com/bdfmne5w
COMBINE Lab@UCL retweeted
Interested in working with neuroimaging and normative modelling in #FTLD? Look no further!
RA post available with me at @drcionucl and @JamesCole_Neuro @CmicUcl funded by @ARUKscientist.
Please RT and do get in touch if interested!
ucl.ac.uk/work-at-ucl/search…
Vacancy Alert 🚨 Research Assistant to join Dr Martina Bocchetta @BocchettaM at UCL working on "From group-level to individual-specific brain signatures in sporadic FTLD-associated disorders". Closing date: 6th June.
dementiaresearcher.nihr.ac.u…
