Associate to the Prof, UNC Neuroscience Center & Dept of Genetics
Chapel Hill, NC
Joined July 2017
- Tweets204
- Following1.7K
- Followers832
- Likes2.3K
Jason Stein retweeted
1/ I’m excited to share our new work, now out in @NatureNeuro! This was a wonderful collaboration with my long-term collaborator @jsteinlab, led by two fantastic trainees, @NanaMatoba and Jessica McAfee.
nature.com/articles/s41593-0…
Jason Stein retweeted
New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome.
#brain #singlecell #multiomics #DownSyndrome
biorxiv.org/content/10.1101/…
Jason Stein retweeted
Stimulating Wnt signaling reveals context-dependent genetic effects on gene regulation in primary human neural progenitors
@jsteinlab @NanaMatoba @jmvalone4 @BrandonDLe
nature.com/articles/s41593-0…
Jason Stein retweeted
It’s been a long journey🚢, with about 1 & 1/2 year since posting on bioRxiv and of course even longer since the project started, but our paper has finally been published in @NatureNeuro 🌠
Congrats @BrandonDLe @jmvalone4 @jsteinlab and all co-authors !
nature.com/articles/s41593-0…
Jason Stein retweeted
📢New from @jsteinlab!
📰 #Genetics of cell-type-specific post-transcriptional gene regulation during human neurogenesis
cell.com/ajhg/abstract/S0002…
Jason Stein retweeted
Dr. Jason Stein's lab (@jsteinlab) at @UNC determined the cross-site reproducibility of human cortical #organoid 🧫 (hCO) differentiation using three independent research groups to assay hCOs in multiple differentiation replicates.
@stemcellreports | bit.ly/4dDxaiJ
Jason Stein retweeted
The authors of @AJHGNews' latest article identify cell-type-specific genetic regulation of RNA editing and alternative polyadenylation in human neurons and neural progenitor cells. Read the full article here: cell.com/ajhg/abstract/S0002… #ASHG @jsteinlab
Jason Stein retweeted
I am beyond excited to share our new paper on massively parallel reporter assays on schizophrenia-associated variants. This is in collaboration with @jsteinlab, @srikosuri, @mikelove, @_josedavila, @brad_ruzicka, @AP_Boyle. 🧵 follows.
Systematic investigation of allelic regulatory activity of schizophrenia-associated common variants dlvr.it/SwBgpY
Jason Stein retweeted
We @jsteinlab are delighted to present our recent preprint investigating the impact of genetic variants on cell-type-specific post-transcriptional regulation in human brain biorxiv.org/content/10.1101/…
Jason Stein retweeted
Neocortical Neurogenesis in Development and Evolution edited by WIELAND B. HUTTNER is out doi.org/10.1002/978111986091…. Superb resource to learn about cortical progenitors; lineages; specification; migration; patterning; cortical regionalisation; folding; disorders; evolution.
ALT Neocortical Neurogenesis in Development and Evolution Editor(s):Wieland Huttner First published:8 August 2023 Online ISBN:9781119860914 |DOI:10.1002/9781119860914 Copyright © 2023 John Wiley & Sons, Ltd. All rights reserved. Includes chapter from Molnar Lab: Towards the Transcriptionally based Classification of L6b in the Adult Mouse Brain (Pages: 317-330) Thomas Henning, Sara Bandiera, Zoltán Molnár https://doi.org/10.1002/9781119860914.ch16
Jason Stein retweeted
Excited to share a new preprint on the cross-site reproducibility of human cortical organoids co-led with Elisa Waxman & Deborah French at CHOP and Satoshi Yamashita & Kazue Hashimoto-Torii at Children's National and my PI @jsteinlab! biorxiv.org/content/10.1101/… 1/9
Jason Stein retweeted
Learn how Felix Kyere, Ian Curtin, Jason Stein and colleagues of @UNC perform whole-brain single-cell imaging and analysis of mouse brains using MRI, tissue clearing, and light-sheet microscopy.
Watch on JoVE: hubs.ly/Q01S6wjB0
@jsteinlab @FelixKyere @curtin_ian
Jason Stein retweeted
Our recent work together with @jsteinlab and @mikelove is published in @GenomeBiology, to understand cell-type specific causal gene regulatory networks via mediation analysis. To access the full article please click
genomebiology.biomedcentral.…
Jason Stein retweeted
Super excited to host @BrandonDLe from @jsteinlab next Tuesday at 3pm for the #neurogenomics seminars. Bran will present the lab's excellent recent work linking wnt pathway activation with context specific regulatory QTLs. DM/email for the zoom link
Jason Stein retweeted
The lightsheet has landed! 🔬🤩🎉
After a lot of preparation and a full week of install, we were thrilled to see some images of distinct nuclei in dense regions of cleared mouse brains and are excited to welcome the @ASIImaging ct-dSPIM to the @UNC_NMC!
ALT The ASI ct-dSPIM lightsheet microscope at the UNC Neuroscience Microscopy Core.
ALT Installing the ASI ct-dSPIM lightsheet microscope at the UNC Neuroscience Microscopy Core.
ALT Scientists looking at images during the installation of the ASI ct-dSPIM lightsheet microscope at the UNC Neuroscience Microscopy Core.
Check out our lab's recent work mapping response ca/eQTLs in the context of Wnt stimulation 🪄⚡️.
Excited to share our new preprint, where we investigated context-specific gene regulation and QTLs by stimulating 🪄⚡️ the Wnt pathway in human neural progenitor cells🧠 (co-led with two wonderful grad students @brandonDLe @jmvalone4 in @jsteinlab) biorxiv.org/content/10.1101/… 1/🧵
Jason Stein retweeted
GWAS in a dish!
GWAS of neural progenitor cell proliferation on lithium treatment (n=80) identified a locus on chr 3, a known risk locus for bipolar disorder, schizophrenia and intelligence. Beautiful!
sciencedirect.com/science/ar…
Jason Stein retweeted
🧬A GWAS study from @jsteinlab has found a common genetic variation that influences lithium-induced neural progenitor proliferation in cell culture. Nice approach to identifying context-specific effects of psychotropic drugs. 👇sciencedirect.com/science/ar…
Jason Stein retweeted
Cell culture-based GWAS approach identifies lithium-induced pharmacogenomic effects on human neural progenitor proliferation mediated by GNL3. Associated with risk for #bipolardisorder and #schizophrenia, intelligence: elsevier.com/about/press-rel…
@BiologicalPsyc1
@jsteinlab
Jason Stein retweeted
@UNC_Biology has a job search for a tenure-track Assistant Professor in neurobiology.
unc.peopleadmin.com/postings…
UNC is a pretty amazing place to do your research, and Chapel Hill is a fantastic place to live, so consider applying and tell your friends!
