@BarmadaLab

Barmada lab @UMich. We study cellular mechanisms underlying ALS/FTD & RNA biology with focus on neurodegeneration. (group-run account)

 Ann Arbor, MI
barmadalab.com/
Joined May 2020
  • Tweets60
  • Following45
  • Followers383
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Just OUT: A fantastic commentary on our paper by @EmilePinarbasi & @BarmadaLab! @jclinicalinvest doi.org/10.1172/JCI168215 Thank you so much!
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Barmada Lab retweeted
mito911@mito911_11 Jan 2023
🎉NEW SPEAKER! 🗣️Dr. Sami Barmada @BarmadaLab 🗓️15th June '23, 11 am EST 📝us06web.zoom.us/webinar/regi…
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6 @UMich scientists & engineers have been named the 2022 winners of the #MBioFAR Award, which recognizes exceptional mid-career faculty in the biosciences. Congrats @BarmadaLab @fu_jianping @LyssiotisLab @AlisonNarayanUM, James Moon, Elizabeth Speliotes. news.umich.edu/six-u-m-resea…
Six U-M researchers receive Biosciences Initiative award for excellence among mid-career faculty

ALT Six U-M researchers receive Biosciences Initiative award for excellence among mid-career faculty

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Congratulations to @AlisonNarayanUM, who has been named a 2022 MBioFAR awardee! This #UMBiosciences award recognizes exceptional mid-career faculty in the biosciences and supports their continued pursuit of innovative, high-risk research. record.umich.edu/articles/si…
Photos of the six MBioFAR awardees. Top row, from left: Sami Barmada, Jianping Fu, Costas Lyssiotis. Bottom row, from left: James Moon, Alison Narayan, Elizabeth Speliotes.

ALT Photos of the six MBioFAR awardees. Top row, from left: Sami Barmada, Jianping Fu, Costas Lyssiotis. Bottom row, from left: James Moon, Alison Narayan, Elizabeth Speliotes.

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Nico Gomez from the @BarmadaLab is primarily interested in exploring how the regulation of nucleic acid, the primary bearer of durable biological information across all living things, can be used to understand and treat disorders of the brain. Read more: rna.umich.edu/faculty/featur…
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Barmada Lab retweeted
Maday Lab@MadayLab20 Jun 2022
Honored to highlight exciting work from @BarmadaLab elucidating mechanisms that regulate autophagy in neurons! sciencedirect.com/science/ar…
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Barmada Lab retweeted
May Khanna
@may_khanna17 May 2022
Excited that this paper is out! Grp78/BiP/ HspA5 binds directly to TDP‑43 and mitigates toxicity associated with disease pathology A clever BioID to drive TDP-43 (not over-expressed) in cytoplasm and nucleus: which Hsp70 modulates TDP-43? rdcu.be/cNJCa 1/4
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Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding biorxiv.org/cgi/content/shor… #bioRxiv
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Barmada Lab retweeted
ShorterLab@ShorterLab14 Dec 2021
Development of a specific live-cell assay for native autophagic flux: jbc.org/article/S0021-9258(2…

Development of a specific live-cell assay for native autophagic flux

Autophagy is an evolutionarily conserved pathway mediating the breakdown of cellular proteins and organelles. Emphasizing its pivotal nature, autophagy dysfunction contributes to many diseases;...

jbc.org
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#JBCEditorsPick | Shining a light on autophagy in neurodegenerative diseases In a recent issue of JBC, Safren et al. described a novel assay that uses a photoconvertible fusion protein to identify compounds that alter autophagic flux — @UMich @BarmadaLab jbc.org/article/S0021-9258(2…
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Barmada Lab retweeted
ShorterLab@ShorterLab22 Jul 2021
TDP-43 according to #AlphaFold, very interesting!! alphafold.ebi.ac.uk/entry/Q1…
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Barmada Lab retweeted
CVV, PhD@cvandevelde7513 Jun 2021
At long last! Excited to share our story about TDP-43 and G3BP1 and its potential relevance to ALS/FTD! @CRCHUM @ALSCanada @UMontreal
Brain@Brain187813 Jun 2021
Sidibé et al. show that TDP-43 stabilizes transcripts encoding the key stress granule protein G3BP1, and that G3BP1 transcript levels are reduced in the neurons of patients with ALS/FTD. bit.ly/3iH3SWC
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Great postdoc opportunity in Dr. Paulson's lab! Join U-M, a leading research public university, where we believe and practice in #DEI. @UMich @umichmedicine @RNASociety @BarmadaLab @EvaFeldmanMDPhD @umich_NeuroNet @INDUCSF
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Our newest preprint is online! DHX36 is a G-Quadruplex resolving DNA/RNA helicase. @UMichCMB⁩ student Lulu Tseng ID’d it as a RAN translation modulator at FXTAS (CGG) and C9ALS/FTD (GGGGCC) repeats. Great collaboration with Phil Smaldino ⁦@bgsu⁩! biorxiv.org/content/10.1101/…

The RNA helicase DHX36/G4R1 modulates C9orf72 GGGGCC repeat-associated translation

GGGGCC (G4C2) hexanucleotide repeat expansions (HRE) in C9orf72 are the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Repeat-associated non-AUG...

biorxiv.org
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Our featured #RNA scientist this week is Dr. Dawen Cai: conta.cc/3vnbTTJ "We use scRNAseq to identify transcription factors that play critical roles in determining neuronal subtypes." @DawenCai @UmichCDB @UMBiophys @kwanlab @EvaFeldmanMDPhD
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Our new paper on Hybridization Chain Reaction detection of repeat RNAs is online. Congrats to Yuan Zhang and Becky Glineburg and thanks to collaborators ⁦@BarmadaLab⁩ for their help. Hopefully will be a useful tool for the field. actaneurocomms.biomedcentral…

Enhanced detection of expanded repeat mRNA foci with hybridization chain reaction

Acta Neuropathologica Communications - Transcribed nucleotide repeat expansions form detectable RNA foci in patient cells that contribute to disease pathogenesis. The most widely used method for...

link.springer.com
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TODAY, March 25, 11-2:30 ET, DAY 1 of our #RNA symposium: KEYNOTE SPEAKERS: Tracy Johnson @TheTracyLab Kevin Weeks @weekslab Feng Zhang @zhangf DATA BLITZES: Cathy Smith @smithcat1661 ; Daniel Peltier, M.D., Ph.D.; Yan Zhang, Ph.D. INFO + REG: bit.ly/3rlA7LM
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Becky Glineburg, Ph.D., Neurology, who works on neurodegenerative diseases, is our featured scientist: conta.cc/2QdrTZa #RNA #fragileX @EvaFeldmanMDPhD
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With your support, we train the next generation of #RNA scientists to help millions of patients. THANK YOU! How do we do this, at the UM Center for RNA Biomedicine? Watch our video and give a head start to Giving BlueDay, March 10: myumi.ch/4p0zX
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Funded Post-doc position now open @UMich in @realToddLab! Help us explore how nucleotide repeats across the genome influence neuronal function and cause disease while developing novel therapies for #FragileX, #ALS, and #Ataxia. Details: tinyurl.com/y3xl8d4j. Please RT.
Once and Future Todd Lab Happy Hour (Picture pre-COVID).

ALT Once and Future Todd Lab Happy Hour (Picture pre-COVID).

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