@kwanlab

The Kwan lab at Univ of Michigan studies neural circuit development, chromatin regulation, & brain disorders using genetics & genomics šŸ§ šŸ§¬šŸ”¬

 Ann Arbor, MI
kwanlab.org
Joined July 2013
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Replying to @kwanlab
Our H3.3 paper is now out in print at PNAS @PNASNews šŸŽ‰šŸŽ‰šŸŽ‰ Congrats to Owen Funk @DrFunk_PhD and team!!! 12/11 pnas.org/doi/10.1073/pnas.21ā€¦

Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal...

Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-independently, provide long-term histone replacement in pos...

pnas.org
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Our latest work led by @ItsClaraLiao is a collaboration with the other Kwan lab @kwanlab We used single-nucleus RNA sequencing to measure transcriptional responses in the mouse medial frontal cortex following a single dose of psilocybin. šŸ„ šŸ§  šŸ§¬ biorxiv.org/content/10.1101/ā€¦
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It was very stimulating to work with Ken Kwan @kwanlab on this review on thalamocortical development for the Cold Spring Harbor Perspectives in Biology cshperspectives.org edited by @L_andreae, @JustusKebschull, and @TonyZador cshperspectives.cshlp.org/cgā€¦ doi.org/10.1101/cshperspect.ā€¦
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On September 1, we welcome MNI's new Executive Director, Ravi Allada, M.D. (@AlladaSleep). Dr. Allada will lead the charge to connect U-M researchers from across campus to explore the brain on a cellular, molecular, and behavioral level. @umich @umichmedicine #neuroscience šŸ§µ
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We will be holding Virtual Open Houses again this year! Sign up to join us as we give you the inside scoop about applications and interviews. We will have current students, faculty, and staff in attendance to answer all of your questions! šŸ§ 
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Excited to share our latest preprint! šŸŽ‰ In this study, we find that the histone H3 variant H3.3 establishes neuronal transcriptome, identity, and connectivity during a critical window in cerebral cortex development. 1/11 biorxiv.org/content/10.1101/ā€¦

Post-mitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal...

Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-independently, provide replacement histones in terminally post-mitotic cells, including neurons. Histone...

biorxiv.org
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Our new CUT&Tag data added in revision further confirms that preexisting, replication-coupled H3 histones are insufficient for establishing neuronal chromatin and transcriptome; de novo H3.3 is required for these processes to postmitocially refine neuronal identity.šŸ‘13/11
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Excited to announce that I will be starting my lab at the @YaleCSC on July 1st. The lab will study the developmental trajectory of psychiatric disorders with a focus on brain connectivity and gene regulation. Come join me, postdoc positions available! pls RT
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Considering #gradschool for #neuroscience and attending #SfN21 #SfN2021 or #ABRCMS2021? If so, come by our @umich booth to chat with students & faculty and learn more about our Neuroscience Graduate Program. We will be available every day, starting today! @SfNtweets @ABRCMS
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Excited to share our two manuscripts published online today. They are the culmination of almost a decade of work in the Sestan Laboratory. We set out to understand how the human prefrontal cortex acquired its molecular identity and connectivity. nature.com/articles/s41586-0ā€¦

Regulation of prefrontal patterning and connectivity by retinoic acid

Nature - Studies in mice, humans and macaques show that retinoic acid signalling has an important role in the development of the prefrontal cortex (PFC) in primates and may also underlie the...

nature.com
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