We are the Institute for Neurodegenerative Diseases @UCSF—Discovering therapies to treat brain diseases such as #CJD, #Alzheimer, #Parkinson, and #dementia
San Francisco, CA
Joined October 2012
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Our Director, Dr. Stanley Prusiner, was awarded a National Medal of Science by Barack Obama in 2009. Today, @NSTMF covers Dr. Prusiner's efforts to redefine Alzheimer's disease #alzheimersdisease #UCSF #science
bit.ly/2MTegJi
Institute for Neurodegenerative Diseases retweeted
Exciting news from the 2026 Tauopathy Challenge Workshop: Four researchers have been awarded a combined $3 million in grants to investigate the structural & thermodynamic properties of tau protein. Read more: prnewswire.com/news-releases…
@aging_mind @alzassociation @CurePSP
Institute for Neurodegenerative Diseases retweeted
As we age, brain cells face a growing mess — including toxic clumps of tau protein. UCSF scientists found a cleanup crew that can remove tau before it clumps, hinting at new ways to prevent dementia. tiny.ucsf.edu/orFiVL
Institute for Neurodegenerative Diseases retweeted
Now online! CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis dlvr.it/TQhKBd
Institute for Neurodegenerative Diseases retweeted
Excited to share our @CellReports article! We investigated how the loss of TBK1 function contributes to ALS and dementia using human stem cell-derived neurons and advanced proteomics. Many thanks to all co-authors for their great work and collaboration!
sciencedirect.com/science/ar…
Institute for Neurodegenerative Diseases retweeted
In this study, we observed that a C9ORF72-ALS/FTD dipeptide repeat protein perturbs the phosphorylation of RNA binding proteins and STMN2 expression, and found that SRSF7 sustains STMN2 levels in induced neurons. Congrats to @JulieSmeyers and Karen! #ALS
actaneurocomms.biomedcentral…
Institute for Neurodegenerative Diseases retweeted
🧠 Multiple system atrophy (MSA) is a #neurodegenerative disease with α-#synuclein #amyloid filament accumulation in the brain.
This #cryoEM study reveals the structure of a new α-synuclein filament subtype in MSA
🖊 Gergory Merz @UCSF & team
➡ bit.ly/40k3q6j
Institute for Neurodegenerative Diseases retweeted
Interested in learning how dyes might help in characterizing protein activity?
We're excited to share the development of a protein-adaptive DSF platform (paDSF), a dye-based method used to interrogate stability, dynamics, and ligand binding!
go.nature.com/4ajNRNp
Institute for Neurodegenerative Diseases retweeted
Excited to share the work done by @taiawu and Zach Gale-Day on DSFWorld: an online open-source software that streamlines the planning and analysis of DSF experiments!
onlinelibrary.wiley.com/doi/…
Institute for Neurodegenerative Diseases retweeted
Proud to share this publication by our postdoc, Shweta Devi! It offers new insights into the interaction capabilities of the TPR domain to EEVD-like motifs in nonchaperone proteins.
jbc.org/article/S0021-9258%2…
Institute for Neurodegenerative Diseases retweeted
So proud to share this. Nick and the team did fantastic work characterizing of new filament fold of MSA! Along with being our first novel filament structure from the IND, it’s also my first corresponding author paper!
biorxiv.org/content/10.1101/…
For its “Conversations with Giants in Medicine” series, @jclinicalinvest interviewed @INDUCSF Director, Dr. Stanley Prusiner. In the interview, Dr. Prusiner discusses his beginnings in science and the path leading to his discovery of prions and the Nobel Prize.
In this episode of JCI’s Conversations with Giants in #Medicine, @UshmaNeill talks with Dr. Stanley Prusiner @UCSF, the 1997 #NobelPrize winner in Medicine for his discovery of #Prions: buff.ly/4cFqH69
#Video: buff.ly/4f7QtSc
Institute for Neurodegenerative Diseases retweeted
Most viewed in the last 7 days from @JAMANeuro:
Viewpoint describes the evidence for iatrogenic disease based on amyloid-β prions and the possibility that AD has an iatrogenic form wherein amyloid β and tau behave as prions that transmit the disease.
ja.ma/3MiEbJO
In a new paper, researchers from the Condello lab and Prusiner lab @INDUCSF describe the creation and characterization of a novel transgenic rat model to study human tauopathy.
link.springer.com/article/10…
Using a novel combination of optical microscopy and cryo-EM, the @SouthworthLab and Condello lab @INDUCSF found that tau filaments from Down syndrome adopt conformations identical to filaments from Alzheimer’s disease.
doi.org/10.1186/s40478-024-0…
Are you an incoming UCSF grad student interested in doing research in neurodegeneration? If you are, join us at the IND OPEN HOUSE @ Helen Diller on 11/15 to meet our current trainees and faculty and to discuss their research!
Register here: forms.gle/sqTX5GLNoHiGymQJA
Institute for Neurodegenerative Diseases retweeted
We’re hiring a postdoc! Please reach out or share if you know someone interested in studying neurobiology and neurodegeneration as part of an outstanding research environment at Mission Bay. @INDUCSF #dementia #ALS
opportunities.ucsf.edu/conte…
Institute for Neurodegenerative Diseases retweeted
Thrilled that manuscript is finally out in @NatureComms! Thanks so much to everyone who worked so hard to push this over the finish line!
nature.com/articles/s41467-0…
Very excited to share a project I’ve been working on (w/ @chalkley_talk) for awhile at the @INDUCSF! We’ve solved a high resolution cryo-EM structure of a Tau PET ligand (GTP-1) bound to AD PHFs. (1/5)
TL;DR: GTP-1 stacks along the filament axis
biorxiv.org/content/10.1101/…
Institute for Neurodegenerative Diseases retweeted
Dr. Nick Paras from @INDUCSF reveals how the lab saw immediate improvements from using #AI and #QuantumTechnologies from our new #AQBioSim division, which allowed them to do meaningful #DrugDiscovery experiments #insilico. Read the story here: bit.ly/44i2HCd #biopharma
Institute for Neurodegenerative Diseases retweeted
Dr. Stanley Prusiner at @INDUCSF has made incredible progress in accelerating lead optimization for neurodegenerative diseases like Alzheimer's and Parkinson's using #AI- and #quantum-powered solutions from our new molecular simulation division, AQBioSim. Find out how our AQ solutions are helping the lab shave years off its #DrugDiscovery timelines. bit.ly/3CFwp7Z
