@Alicardsdoc

Heart failure Transplant cardiologist, basic/translational researcher.

 St Louis, MO
Joined March 2018
  • Tweets1.1K
  • Following972
  • Followers685
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Super excited to share our exciting new work with you. sciencedirect.com/science/ar… Great collaborative effort! @carmenbergom @DrLPedersen @carlavripoll @muallaozcan @RentschlerLab @WUSTLmed @DoctorPhillEP @WUSTLnews @WashUCardiology
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Eric Topol
@EricTopolOct 15
In 100% agreement Exercise should be a prescribed New @JACCJournals @ACCinTouch scientific statement jacc.org/doi/10.1016/j.jacc.…
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Apte Lab@ApteLabSep 3
Apte Receives 2026 APVRS International Award Lecture | Ophthalmology & Visual Sciences ophthalmology.wustl.edu/apte…

Apte Receives 2026 APVRS International Award Lecture | Ophthalmology & Visual Sciences

Apte Receives 2026 APVRS International Award Lecture

ophthalmology.wustl.edu
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Aarti Asnani@AartiAsnaniMDAug 28
New work from our lab led by @AbeBayer identifies PIGR and CPVL as immune-related biomarkers of anthracycline cardiotoxicity: ahajournals.org/doi/10.1161/… @BidmcCvi @TuftsMedSchool

Plasma Proteins Associated With the Immune Response to Anthracycline Cardiotoxicity in Patients...

BACKGROUND: Anthracyclines such as doxorubicin are well recognized to induce dose-dependent cardiotoxicity. However, traditional imaging and blood biomarkers of myocardial injury are inadequate for...

ahajournals.org
Abe Bayer, PhD@AbeBayerAug 27
Very excited to share our new paper using plasma proteomics to look for potential biomarkers in anthracycline toxicity now out in @CircHF! We find new immune proteins that correlate with decreased LVEF in lymphoma/leukemia patients after anthracycline tx ahajournals.org/doi/10.1161/…

Plasma Proteins Associated With the Immune Response to Anthracycline Cardiotoxicity in Patients...

BACKGROUND: Anthracyclines such as doxorubicin are well recognized to induce dose-dependent cardiotoxicity. However, traditional imaging and blood biomarkers of myocardial injury are inadequate for...

ahajournals.org
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📢 New Review Cardiovascular aging through the lens of Blue Zones What can the world's longest-lived populations teach us about cardiovascular aging? Corresponding author: Dr. Ali Javaheri @Alicardsdoc 🔗 oaepublish.com/articles/jca.… #CardiovascularAging #BlueZones #Longevity
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CircEP@CirculationEPMay 22
We identified RACGAP1 as a novel biomarker for atrial fibrillation in heart failure, validated across two large independent patient cohorts @JulioChirinosMd @DLMANN_MD @MorenoMDPhD @Alicardsdoc #Epeeps ahajrnls.org/3Rgb4fX
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Longevity research is being starved of funds just when the US needs to be more competitive. Have assembled a team working on it. Launch date: April 2026 nytimes.com/2026/03/13/us/hi…

His Harvard Lab Was Thriving. Then Came the Cuts.

Will Mair, who studies aging, lost almost all his research funds when the White House cracked down on Harvard. He was wholly unprepared for the upheaval that followed.

nytimes.com
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Circ: Heart Failure@CircHFJan 29
Increased dephospho-uncarboxylated matrix Gla-protein levels were associated with adverse outcomes in heart failure @DLMANN_MD @Alicardsdoc @mkvidula @mariejoedib @JulioChirinosMd @PennCardiology ahajrnls.org/4a2AnHL
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Farah Sheikh@FarahSheikhLabJan 26
📣🎉 Exciting news! Our lab’s new paper in #CirculationHeartFailure reports a gene therapy for arrhythmogenic cardiomyopathy. Restoring connexin-43 improves electrical & mechanical coupling, rescues disease & extends survival across severe ACM genotypes. ahajournals.org/doi/10.1161/…
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Thrilled to share our new preclinical paper: low-dose (nonablative) cardiac radiation reduces VT/VF in NICM — associated with improved ventricular conduction and sympathetic nerve distribution. Grateful for our stellar team: @alicardsdoc @carmenbergom @drlpedersen @doctorphillep @rentschlerlab and first author Devaki Abhyankar. 🔗 doi.org/10.1016/j.jacep.2025… #Electrophysiology #VT #CardioOncology #TranslationalScience @uclahealthnews @jaccjournals
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Congratulations @LodhiLab @RazaniLab @BrestoffLab this is awesome !
Irfan Lodhi@LodhiLab17 Sep 2025
Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D nature.com/articles/s41586-0… @WashUDeptMed
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Circulation@CircAHA21 Aug 2025
Single-nucleus RNA-seq reveals CD47 as a key driver of doxorubicin cardiomyopathy. Blocking CD47 protects the heart—offering a new therapeutic path. 🫀🧬@SDPrabhuMD @AartiAsnaniMD @BKopeckyMDPhD @twinsmc18 @AhmedAADiab @carmenbergom @Alicardsdoc ahajournals.org/doi/full/10.…
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Blocking #CD47 has emerged as promising therapy in #CVD. Check out work in @CircAHA by Zhen Guo of @Alicardsdoc lab identifying CD47 in #cardiomyopathy #heartfailure induced by doxorubicin & targeting it as novel therapy. Great partnering with you on this. ahajournals.org/doi/10.1161/…
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🚨Two new JACC Advances papers drop today linking SGLT2 inhibitors ↔ apolipoprotein M (ApoM) across very different settings—ambulatory HFrEF (DEFINE-HF) and acute inflammation (LPS-sepsis & COVID-19). Let’s unpack why this kidney-liver-vascular axis matters. A 🧵 1️⃣/15
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medicine.washu.edu/news/stra… Great collaborative effort with @ApteLab @washumedicine @WashUCardiology @ZSky17 identifying a new role for ApoM in macular degeneration

Strategy to prevent age-related macular degeneration identified | WashU Medicine

A new study from WashU Medicine in St. Louis identifies a possible way to slow or block age-related macular degeneration, a leading cause of blindness in people over age 50.

medicine.washu.edu
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CircEP@CirculationEP22 May 2025
Stereotactic arrhythmia radiotherapy (STAR) treats VT by locally increasing ERP, not increasing scar burden #AHAJournals #Epeeps @pmjboyle @Alicardsdoc @SBRTCR @brianzenger @carmenbergom @JulieSchwarz14 @RentschlerLab doi.org/10.1161/CIRCEP.124.0…

STAR Locally Prolongs Effective Refractory Period and Increases Ventricular Tachycardia Cycle...

BACKGROUND: Stereotactic arrhythmia radiotherapy (STAR) has emerged as a potential therapy for treatment-refractory ventricular tachycardia (VT). However, the mechanisms underlying STAR efficacy,...

ahajournals.org
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We thank all our @RazaniLab members and many collaborators in making this happen 🤝 (@XiangyuZ0321 @kratky_lab @Alicardsdoc @hanrui_zhang @ParthaDuttaLab @StraubLab @LodhiLab include those with Twitter handles)
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Plasma SVEP1 Levels Predict Cardiovascular Events in Hypertrophic Cardiomyopathy Beyond Conventional Clinical Risk Models Including NT-proBNP @keitaroakita @Alicardsdoc @MathewMaurer @Osawa_Itsuki #AHAJournals ahajrnls.org/4aCVsbP
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nature
@Nature24 Feb 2025
The Trump administration's efforts to slash research funding have US graduate students, postdocs and other early-career scientists fearing for their careers. Some are considering changing jobs or leaving the country. Others say them might abandon research altogether. go.nature.com/4hO8k1u
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Congrats to @ZSky17 for excellent work on this editorial and great work from Medina-Hernandez and colleagues - excited for future human clinical trials to prevent AIC sciencedirect.com/science/ar… -
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EdT@thorplab11 Feb 2025
Early-age efferocytosis directs macrophage arachidonic acid metabolism for tissue regeneration: Immunity cell.com/immunity/fulltext/S…
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