@LodhiLab

Professor of Medicine at Washington University| Studying lipid metabolism| Adipocyte Biology, BAT, Diabetes, NAFLD, Obesity, Peroxisomes| PhD UMICH

 Saint Louis, Missouri
LodhiLab.org
Joined January 2020
  • Tweets351
  • Following702
  • Followers977
18Media
Happy to share our new paper in @Nature led by staff scientist Xuejing Liu @Jessielxj2. We report identification of a UCP1-independent pathway of brown fat thermogenesis involving ATP-consuming metabolism of BCFA in peroxisomes. #Obesity #T2D nature.com/articles/s41586-0… @WashUDeptMed
17
37
5
155
14,911
Irfan Lodhi retweeted
nature
@NatureOct 14
A massive study of more than 100,000 people finds surprise connection between ‘good’ body fat and improved mental health go.nature.com/47kU4tz

Overlooked brown fat in our bodies linked to wide range of health benefits

Nature - Massive study of more than 100,000 people finds surprise connection between ‘good’ body fat and improved mental health.

nature.com
14
140
17
602
74,350
Irfan Lodhi retweeted
Aaron Cypess@acypessSep 2
This is a top lab in the entire world. Join for the science, stay for the mentoring and camaraderie. @tsengyuhua
Yu-Hua Tseng@tsengyuhuaSep 2
📢 Postdoc opening in the Tseng Lab @JoslinDiabetes @harvardmed! Explore how thermogenic adipocytes shape whole-body metabolism. Strong background in molecular/cell biology + metabolism required; adipocyte biology a plus. yhtsenglab.org/

Video on

Visit the post for more.

yhtsenglab.org
2
4
623
Irfan Lodhi retweeted
Eric Topol
@EricTopolAug 27
From a randomized trial, the advantage of a ketogenic diet vs Mediterranean or low fat plant diet for people with pre diabetes and fatty liver (hepatic steatosis) cell.com/cell-metabolism/ful…
40
124
7
506
98,753
New year resolution to post more! Proud of @yushengyeh & @RazaniLab members for their @atvbahajournals review this month comparing/contrasting newly discovered #adipocyte #lipolysis via #lysosome #LIPA vs. known cytoplasm #ATGL in #cardiometabolic #CVD 💪 ahajournals.org/doi/10.1161/…
1
8
1
34
2,410
Excited to share our new publications working with @AlbertHKimMDPhD. We developed a stem cell model of glioblastoma (GBM) and uncovered how INSM1 programs a progenitor network that fuels GBM progression nature.com/articles/s41467-0…

INSM1 governs a neuronal progenitor state that drives glioblastoma in a human stem cell model

Nature Communications - Glioblastoma (GBM) is characterized by a high degree of heterogeneity and plasticity due to interplay with neural developmental programs. Here, the authors develop a model...

nature.com
2
5
41
3,271
Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure | Science science.org/doi/10.1126/scie…

Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure

Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains...

science.org
6
14
1,396
Dual inhibition of ACLY and ACSS2 by EVT0185 reduces steatosis, hepatic stellate cell activation, and fibrosis in mouse models of MASH dlvr.it/TQJ9h0
16
67
3,575
Our body (cells) have fuel preference, e.g., burning fat vs. carbohydrates, which depends on the environment and nutritional states. How do cells decide which fuels to use?  Our new study found that carnitine biosynthesis is crucial for fuel switching science.org/doi/10.1126/scie…

Mitochondrial control of fuel switching via carnitine biosynthesis

Environmental adaptation often involves a shift in energy utilization toward mitochondrial fatty acid oxidation, which requires carnitine. Besides dietary sources of animal origin, carnitine biosyn...

science.org
10
96
6
426
51,119
Irfan Lodhi retweeted
Jie Sun
@Jie_ImmunologyJan 8
Peroxisome-dependent ether lipid down regulation is also a prominent feature of ME/CFS patient lipid profiles. Our prior work and this new study call for a clinical trial of sodium phenylbutyrate that can boost peroxisome function on Long COVID 🙏🙏@NIAIDNews
Jon Douglas
@atranscendedmanJan 7
I find it interesting that sodium phenylbutyrate was found in this study and even @Jie_Immunology's science.org/doi/10.1126/scie… to help reverse this in lungs and now gut? Clinical trial soon?

Macrophage peroxisomes guide alveolar regeneration and limit SARS-CoV-2 tissue sequelae

Peroxisomes are vital but often overlooked metabolic organelles. We found that excessive interferon signaling remodeled macrophage peroxisomes. This loss of peroxisomes impaired inflammation resolu...

science.org
2
12
39
3,243
Excited to see this work published in Nature Metabolism! This study provides new insight into how normally stable adipocytes can be mobilized under extreme metabolic stress, independent of sympathetic signaling. Congrats to @schellerlab and the team!
Scheller Lab@schellerlabJan 9
Very happy to start 2026 by sharing our new manuscript in Nature Metabolism.✨ By studying the constitutive adipocytes in the bone marrow, we identified a brain-mediated pathway that bypasses the SNS to evoke massive fat loss. 🧠🦴 Full article here: lnkd.in/gH7eHv4r
1
11
426
Thank you @NIH for highlighting our recent @Nature paper! Extremely grateful for the support that made this work possible.
NIH
@NIH25 Nov 2025
Unlike the white fat cells you may be familiar with, brown fat cells use energy to produce heat. NIH-supported researchers identified a previously unrecognized way these cells use energy. The findings suggest a potential way to promote weight loss by increasing heat generation in brown fat cells. bit.ly/3LSxeSK
Infrared images of heat production from brown fat in a control mouse (left) and a mouse that lacks a protein called ACOX2 (right). Weisensee Lab

ALT Infrared images of heat production from brown fat in a control mouse (left) and a mouse that lacks a protein called ACOX2 (right). Weisensee Lab

1
5
1
42
11,459
Shingo, thanks so much for highlighting our recent paper! Looking forward to exploring this further.
Shingo Kajimura Lab@KajimuraLab6 Nov 2025
Super interesting ! A new UCP1-independent thermogenic mechanism in peroxisomes sciencedirect.com/science/ar…
10
1,503
New content online: Novel UCP1-independent thermogenic mechanism identified bit.ly/47jtFvZ
2
8
27
2,444
Thrilled to share our work on adipose tissue heterogeneity out today in @emboreports! Huge congrats to first author Hoang Bui, Juli Hansen, and our special collaborator @valelosardo for guiding us through the mysterious world of single-cell analysis! embopress.org/doi/full/10.10…
3
6
1
27
2,156
A consensus guide to preclinical indirect calorimetry experiments go.nature.com/4nkLRvR

A consensus guide to preclinical indirect calorimetry experiments

Nature Metabolism - The authors highlight inconsistencies and divergencies in the literature reporting data on indirect calorimetry for studies on whole-body energy homeostasis, and propose...

nature.com
1
19
55
5,076
Happy to share new work led by outstanding former grad student Kubra Akkaya! Following up on our previous work, we show that Stearoyl-CoA Desaturases (SCDs) regulate intestinal stem and progenitor cell function and proliferation, shaping epithelial homeostasis and regeneration.
2
5
22
1,884
I remember watching @LodhiLab @WashUMedEndo present this stunning work on peroxisomal thermogenesis at WashU and thinking "That's a Nature paper!" Now it is: nature.com/articles/s41586-0… And I like these "Briefings" that let the authors discuss their findings: nature.com/articles/d41586-0…

Peroxisomal metabolism of branched fatty acids regulates energy homeostasis

Nature - A UCP1-independent mechanism of thermogenesis involving ATP-consuming metabolism of monomethyl branched-chain fatty acids in peroxisomes is described and a previously unrecognized role for...

nature.com
3
1
14
844
Out today in @CellReports! We found that coxsackievirus B3 (CVB3), which is associated with increased risk of #T1D, infects all human pancreas cell types, not just beta cells. Great collab with @hubert_tse KUMC. Led by @WashUdbbs PhD student @dveronese18 cell.com/cell-reports/fullte…

Coxsackievirus B infection invokes unique cell-type-specific responses in primary human pancreatic...

Veronese-Paniagua et al. demonstrate that coxsackievirus B3 infects all primary human islet cell types and elicits distinct cell-type-specific transcriptional and mitochondrial responses. They...

cell.com
2
8
40
2,161
[please retweet] I’m #hiring! The Millman Lab is looking for a postdoctoral researcher to lead an exciting new project focused on vascularized #stemcell-derived islets for #diabetes disease modeling and cell replacement therapy. Email me your CV and cover letter.
1
31
60
9,318
Load more