@UCB_Chemistry PhD Candidate @schepartzlab/@cgem_cci 🐻 | @NUChemistry & @MirkinGroupNU Alum | 🇵🇷🇭🇰 | also @alexsolivan on the other place 🟦☁️
Joined March 2021
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Alex Solivan retweeted
Check it out! Genome-wide phage transposon mutagenesis and sequencing (Phage Tn-seq). In nucleus-forming jumbo phages (phiKZ and KTN4) and a hypermodified phage (YuA). Lot's of unexpected discoveries and seeds for new research directions! sciencedirect.com/science/ar…. 🧵
Alex Solivan retweeted
Many experiments in biology happen one protein at a time, which means synthesizing DNA one gene at a time. This is fine for tens of genes. For thousands, the cost is unsustainable.
Introducing uSort-M: a method to isolate and sequence-verify thousands of genes at low cost
Alex Solivan retweeted
Excited to begin my postdoctoral appointment soon in the laboratory of Prof. David Liu at the Broad Institute!
This is a big pivot from natural product synthesis, but I am eager to contribute everything I can to gene editing and protein design!
Thanks everyone for your support!
Super cool work Neal! Did you guys notice any resin decomp issues during your cross coupling? 110C for 18h is the hottest on-resin reaction I think I’ve seen before
Alex Solivan retweeted
Inspiring day at the @berkeleyMCB Molecular Therapeutics Division retreat at Bakar BioEnginuity Hub! Grateful to our trainees for sharing their research and to keynote Kevin Eggan (CSO at BioMarin) for insights into translating basic science into life-changing therapeutics.
Alex Solivan retweeted
Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0).
doi.org/10.26434/chemrxiv-20…
Alex Solivan retweeted
Excited to share that I successfully defended my independent research proposal today, and I am now ABD (all but dissertation)!
Alex Solivan retweeted
We detail the design & synthesis of metal-ɑ-helix frameworks. If you are just interested in learning how to make #peptides, we have provided a thorough procedure for setting up your first solid phase peptide synthesis (#SPPS)!
Article free until Sept 6! tinyurl.com/v47fade9
Alex Solivan retweeted
Barry Trost's adage continues to echo "The problem with the Wittig reaction....is that it works"
Alex Solivan retweeted
I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces.
biorxiv.org/content/10.1101/…
Most “rules in chemistry” don’t really hold up or could actually end up steering you wrong so don’t get too tied up them. Recognizing patterns and learning how one experiment can teach you what to do in the next is really the secret sauce
Alex Solivan retweeted
Our approach to the total synthesis of chartelline C, out now in JACS. Photochemistry and unique topology gave way to some really interesting reactivity!
pubs.acs.org/doi/10.1021/jac…
