@sp3intermediate

Biocatalysis, Pharmacology, Swimming. @KFBChem Postdoc @WuestLab alumni (‘25) @KenyonCollege swammer & alumni (‘20) he / him / his 🇯🇵

Atlanta, GA
Joined September 2019
Check out @HJLChem and I’s recent report on using VHPO enzymes to prepare oxindoles and spiro-oxindoles! Excited to see this work out and help eliminate the need for hazardous halogenating reagents and harsh oxidants. Go team VHPO!
KFB Lab Alert: Our general biocatalytic platform for the oxidative rearrangement of indoles is now online at @ChemRxiv! Congratulations to @HJLChem and @sp3intermediate for leading this work with Sergio, Raina, Ana, Sophie, and John! chemrxiv.org/engage/chemrxiv…
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🚀Unlocking CO₂ ·– for two distinct photocatalytic regimes for selective activation of Ar-X(Br/Cl) for Cyclization-Carboxylation. Just now out in @ACSCatalysis 🔓 Once again it’s pleasure working with @Shantanu_JUchem 🍻 ⛓️‍💥Read the full article here: doi.org/10.1021/acscatal.6c0…
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#TotalSynthesis of (±)-Stemocurtisine via Catalytic Carbonylation by Mingyu Zhang (@zhangmy_01), Hailey Yu, Xiao Huang, and @MingjiDai at @EmoryChem in @J_A_C_S pubs.acs.org/jacsat/article/…
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Check out our latest publication in @J_A_C_S ! In this study, we developed a new alkyl-to-alkyl palladium migration reaction that enables remote C–C bond formation through cross-dehydrogenative coupling. Congratulations to Yangjin and Dan! @nyuchemistry pubs.acs.org/jacsat/article/…
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Love the chlorination induced ring contraction!
RCC to the RESCUE: A rapid, convergent synthesis of roussoellatide enabled by redox-neutral radical cross-coupling, completed by @Nima_Nasiri_. A case study in how RCC prevails when classical polar methods fail. Out now in @ChemRxiv : chemrxiv.org/doi/abs/10.2643…
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KFB Lab Alert: I am honored and humbled that our team has received the Eli Lilly Grantee Award this year! I am incredibly grateful for the recognition and proud of the work it represents. I also want to thank April Hunt for a wonderful article in the Emory News! news.emory.edu/stories/2026/…
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I’m excited to announce my first co-author publication as a chemist! We (@WuestLab) disclose the total synthesis of 5 pyridone alkaloids, diverging from a single linchpin intermediate and relying on a late-stage convergent strategy. (1/2) doi.org/10.1039/d6sc04572c
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Generative AI can harm learning. A field experiment published in PNAS randomized nearly 1,000 high-school students across three conditions during mathematics classes: - textbooks and notes only
- a standard GPT-4 interface
- a safeguarded GPT-4 tutor that provided hints rather than answers Students first completed practice problems with these resources. Immediately afterwards, they took a closed-book, closed-laptop exam on similar problems. The results are impressive. During practice, AI made students look much better: Standard GPT-4: +48%
Safeguarded GPT tutor: +127% But when the AI was removed, students who had used standard GPT-4 performed 17% worse than students who had never used AI. The apparent improvement concealed a deterioration in learning. The safeguarded tutor eliminated this negative effect, but produced no improvement in independent exam performance. The reason? Simple: Students using standard GPT-4 frequently asked for the answer and just copied the solution. They surrendered cognition. I’m very concerned, especially for children who will have more and more unregulated access to generative AI and may never develop critical thinking skills. * Paper in the first reply
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Replying to @J_A_C_S
@J_A_C_S Is the plan with the new platform to eventually have TOCs graphics on the ASAPs page again? If not, that functionality is sorely missed!!
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Thrilled to share our latest work, now published in ACIE! We introduce an anomeric amide-enabled platform for divergent aldehyde functionalization, enabling one-pot access to unsymmetrical ureas, carbamates, thiocarbamates, thioesters, amines, and amides. onlinelibrary.wiley.com/doi/…
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Check out our ChemRxiv preprint on direct amine umpolung: a one-step conversion of primary amines into versatile electrophilic aminating agents using MPO, enabling amination, complex fragment coupling and chiral hydrazine synthesis. Congrats to the team! chemrxiv.org/doi/abs/10.2643…
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#TotalSynthesis of Indigotinoline A and Enabled Stereochemical Revision of Isatindigotindoline B by Jiaji Li, Zhibin Zhao, Peiyuan Yang, Mingquan Wang, Sen Zhang, Tianyu Lv, Lianjie Zhang, Lu Yang, Shaojiang Song, Xiaoxiao Huang, Yongxiang Liu in @JOC_OL pubs.acs.org/doi/10.1021/acs…
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Sp3 Methylene CH coupling with heteroaryls has been limited (really annoying for medichemists). With bifunctional pyridone ligands and new mechanism via Pd(II)/Pd(0), we made a big stride: doi.org/10.26434/chemrxiv.15…
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Check out our recent work on a systemic analysis of N-heterocycle halogenation with our favorite chloroperoxidase! Big thanks to Sergio, Hannah, and @jbacsa1 for the help! Got a tricky halogenation with poor selectivity or yield? Please let us know, we’d love to give it a try!
KFB Lab Alert: One Biocatalyst, LOTS of N-Heterocycle Halogenations! Our latest work on the development of an efficient screening workflow for VHPO halogenation is now online @ChemRxiv. Huge congratulations to @sp3intermediate for leading this work with an awesome team of Sergio, @HannahSlocumb5, and @jbacsa1! #Haloplates chemrxiv.org/doi/full/10.264…
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KFB Lab Alert: One Biocatalyst, LOTS of N-Heterocycle Halogenations! Our latest work on the development of an efficient screening workflow for VHPO halogenation is now online @ChemRxiv. Huge congratulations to @sp3intermediate for leading this work with an awesome team of Sergio, @HannahSlocumb5, and @jbacsa1! #Haloplates chemrxiv.org/doi/full/10.264…
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