Bio-Organic-Inorganic l Assistant Professor of Pharmacology, Weill Cornell Medicine
NY, NY
Joined August 2018
- Tweets125
- Following262
- Followers510
- Likes15
Pinned Tweet
I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces.
biorxiv.org/content/10.1101/…
Because µMap labeling works equally well for all types of protein targets, Affinity Map can be applied in challenging biological settings (live cells, cell lysate, brain membrane extract) and is compatible with many types of ligand (small molecules, peptides, proteins).
This work was led by Charles Warren @chardw98 and Noah Yardeny (@Noahyardeny93), who are both co-first authors and the co-first graduate students to join my lab in 2022, with key contributions from Siyang Peng (data processing) and Colin Burdette @colin_burdette (benchmarking).
The Geri Lab is recruiting postdoctoral scholars to develop photocatalytic proximity labeling and proteomics technologies. Chemical biologists and chemists who want to learn chemical biology are welcome!
gerilab.weill.cornell.edu/te…
The view from our recently expanded NYC lab space:
Excited to announce that our group's work on chemical biology technology at Weill Cornell Medicine at is now funded via a NIGMS R35 MIRA grant!
I was really impressed by the recent crop of text prompt to image AI tools and wanted to see how they would depict molecular interactions. Needless to say, I'll stick with Illustrator for now.
Prompt:
"MDM2 interacting with a peptide"
Result (DALL-E 2):
Jacob Geri retweeted
Me: Can I have a #structure of my #protein of interest?
Alphafold: We have it in the #database, no need to make new one.
Structure in the database:
Amazing to see a plan come together! This paper unambiguously shows the tight labeling radius of antibody-targeted µMap labeling compared to other methods, and how reactive intermediate lifetime can be exploited to tune proximity labeling radii.
pnas.org/doi/abs/10.1073/pna…
Two PhD students and one postdoctoral scholar joined the lab this summer! Welcome Noah, Charlie, and Peter! @chardw98 @Noahyardeny93 @94peter
Jacob Geri retweeted
New R21 on identifying novel drug targets is getting funded! Excited to be working with @JacobGeri1 here at @WeillCornell
Our TIMSTof Pro 2 (a cutting edge LCMS for proteomics) is now installed and fully operational! Here is a picture of Alan, the Bruker rep, manuvering it with help from Maxim and Zahir. It extends vertically into the ceiling, as all awesome instruments should.
cen.acs.org/biological-chemi…
Hidden "-omes" lie beyond our technological horizons. This is a highly underrated problem in chemical biology.
Had a fantastic weekend in Princeton celebrating Dave's Nobel! It was amazing to reconnect with so many old friends (like Tao Wang, pictured) and group alumni (>75!)- an unforgettable experience. @dmac68 @MacMillan_Lab
Jacob Geri retweeted
I remember being 7 years old and watching the man who played Capt Kirk on TV. Today I got the chance to chat with the real life astronaut @WilliamShatner and it was out of this world. Talked about organocatalysis, blue origin & carbon removal and he even said hi to Jim McCusker!
We are actively recruiting a postdoc interested in working on developing new chemical biology tools for protein interaction discovery. If interested, please email me at [email protected]!
gerilab.weill.cornell.edu/te…