@AlexSolivan

@UCB_Chemistry PhD Candidate @schepartzlab/@cgem_cci 🐻 | @NUChemistry & @MirkinGroupNU Alum | 🇵🇷🇭🇰 | also @alexsolivan on the other place 🟦☁️

Joined March 2021
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Happy to officially be a PhD candidate now! Thank you to everyone who has supported me this past year! @schepartzlab @AlannaSchepartz @cgem_cci @MillerGroupYale @cate_lab @UCB_Chemistry
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Check it out! Genome-wide phage transposon mutagenesis and sequencing (Phage Tn-seq). In nucleus-forming jumbo phages (phiKZ and KTN4) and a hypermodified phage (YuA). Lot's of unexpected discoveries and seeds for new research directions! sciencedirect.com/science/ar…. 🧵
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Replying to @sp3intermediate
@sp3intermediate
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Micah Olivas@MicahOlivas1May 11
Many experiments in biology happen one protein at a time, which means synthesizing DNA one gene at a time. This is fine for tens of genes. For thousands, the cost is unsustainable. Introducing uSort-M: a method to isolate and sequence-verify thousands of genes at low cost
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Excited to begin my postdoctoral appointment soon in the laboratory of Prof. David Liu at the Broad Institute! This is a big pivot from natural product synthesis, but I am eager to contribute everything I can to gene editing and protein design! Thanks everyone for your support!
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James Olzmann@OlzmannLab4 Sep 2025
Inspiring day at the @berkeleyMCB Molecular Therapeutics Division retreat at Bakar BioEnginuity Hub! Grateful to our trainees for sharing their research and to keynote Kevin Eggan (CSO at BioMarin) for insights into translating basic science into life-changing therapeutics.
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Zondlo Lab@ZondloLab26 Aug 2025
First day of 50th grade! First day of my 25th year at @UDelaware!
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Richard Liu@RichrdLiu7 Aug 2025
Adding to the growing toolbox of aryl azide syntheses: From @Shangyu_Li on @ChemRxiv, Pd-catalyzed coupling of ArBr/ArOTf with NaN3. This reaction is trickier than it looks: as we show, [LPd-N3]2 dimers form with many L's & the pdt can inhibit Pd(0). doi.org/10.26434/chemrxiv-20…
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Replying to @NaOHBartfield
I'm really enjoying their new flavor, "Oops, All Heterocycles!"
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Excited to share that I successfully defended my independent research proposal today, and I am now ABD (all but dissertation)!
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We detail the design & synthesis of metal-ɑ-helix frameworks. If you are just interested in learning how to make #peptides, we have provided a thorough procedure for setting up your first solid phase peptide synthesis (#SPPS)! Article free until Sept 6! tinyurl.com/v47fade9
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Barry Trost's adage continues to echo "The problem with the Wittig reaction....is that it works"
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Jacob Geri@JacobGeri17 Jul 2025
I'm excited to share my lab's first preprint! It describes Affinity Map, a highly general method providing proteomic profiles of binding affinity for small molecules, peptides, and antibodies in cell lysate, organ extracts, and live cell surfaces. biorxiv.org/content/10.1101/…
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Our approach to the total synthesis of chartelline C, out now in JACS. Photochemistry and unique topology gave way to some really interesting reactivity! pubs.acs.org/doi/10.1021/jac…

Total Synthesis of Chartelline C

Abstract. Chartellines are cytotoxic marine alkaloids that were isolated in the late 1980s. Their unique, heavily oxidized structures, comprising a spirocy

pubs.acs.org
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Congrats to MCB postdocs Aurora Alvarez-Buylla (Schepartz Lab), Grace Hibshman (Nogales Lab) and Heegwang Roh (Rapé Lab) for being selected as 2025 Jane Coffin Childs Fellows! 🎉👏 @schepartzlab @NogalesLab @RapeLab @heegwangroh jccfund.org/fellows/class-of…
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After applying to 9 PhD programs, I was disappointed to only get into 1. My mom told me, “Bloom where you’re planted.” 6 years later — I received multiple invitations to give talks, won several awards, was named a rising star, got my paper accepted in Nature. I guess I bloomed.
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⚡️@Elya_Kandahari10 May 2025
Are you guys still interested in having a fundamental understanding of chemical reactivity? Or is it just me & Ken Houk😕
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We are excited to announce our @J_A_C_S paper on frameworks with metalloprotein-like sites! ɑ-helices designed to assemble by metal-coordination and the hydrophobic effect. Point mutations yield unique frameworks with diverse metalloprotein-like sites. tinyurl.com/jk62cb27
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Metal-α-Helix Peptide Frameworks | Journal of the American Chemical Society @thisisUIC pubs.acs.org/doi/10.1021/jac…

Metal-α-Helix Peptide Frameworks

Abstract. Metal–peptide frameworks (MPFs) are a growing class of metal–organic frameworks with promising applications in metalloprotein mimicry, chiral sep

pubs.acs.org
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Hot off the press in @NatureChemistry: Our paper on seed-competent stapled peptides that mimic the core fold of pathological tau! rdcu.be/ej4ik Huge congrats to Isaac, Ben, and collaborators in the Jiang and Vidal labs. #PeptideScience #tau nature.com/articles/s41557-0…
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I am sharing this preprint from my group. Inspired by all the great recent skeletal editing work, we developed an atropisomer selective strategy to take Indoles to quinolines. chemrxiv.org/engage/chemr...
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