TRP nerd
Reno, NV
Joined March 2009
- Tweets710
- Following796
- Followers564
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Scott Earley retweeted
Excitability isn't intrinsic to ion channels alone; it's an emergent property of the CMIC Axis. @vesselman & I link Capillaries, Mitochondria & Channels to function. Break the link, lose the function. doi.org/10.1113/JP289492 @JPhysiol @ucd_physiology
Already sold out at Amazon!
Delighted to receive copies of the (just published) book on statistics that @JakubTomek13 and I have written. Presents statistics and related experimental design without maths and jargon. Available from: amazon.com/Basic-Statistics-… or wiley.com/en-us/Basic+Statis…
Scott Earley retweeted
It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination.
nature.com/articles/s41593-0…
Scott Earley retweeted
Great work from the @trebaklab et al! Congratulations!
Loss of the calcium sensor #STIM2, but not of STIM1, worsens #ColorectalCancer growth and metastasis by boosting calcium ion content in the endoplasmic reticulum, remodeling mitochondria, and rewiring transcriptional activity. @TrebakM @Trayambak_P scim.ag/44v3O3E
A fantastic review from Hugh Markus and Anne Joutel!
The pathogenesis of cerebral small vessel disease and vascular cognitive impairment | Physiological Reviews | American Physiological Society journals.physiology.org/doi/…
Scott Earley retweeted
🎉 Excited to share our new paper in Science Signaling on #brain #pericytes constriction and TRPC3 channel—now published, featured on the cover, and highlighted in a Focus by @vesselman
🧠🧪 Check it out: science.org/toc/signaling/18…
@AMCPharmacology @CUAnschutz #Neurovascular #TRP
Scott Earley retweeted
#Microtubule #SmoothMuscleCell Contractility
MT support #SarcoplasmicReticulum - #PlasmaMembrance contact
RyR2 channel clusters on tubulin filaments
Nocodazole (but not actin toxins latrunculin B or swinholide A)
⏫Ca2+ spark spread
⏬RyR2-BKα co-localization
⏬STOC
⏫myogenic tone
↔️vasoconstriction (KCl, U46619)
Freshly isolated (< 6h) mouse/rat pia resistance arterial SMC
@HAT_Pritchard @vesselman @scisignal 2017
science.org/doi/10.1126/scis…
Scott Earley retweeted
New paper from the lab in press in JBC. Please check it out.
jbc.org/article/S0021-9258(2…
Here's a free link to our commentary on the latest paper from @NelsonLab1
Shocking insights for neurovascular coupling: Electrical signals ignit... sciencedirect.com/science/ar…
Scott Earley retweeted
Just over 2 days left to apply for our PhD project! Please share and apply before Friday
Are you interested in discovering how blood flow to the brain is controlled and how it goes wrong in dementia? We have a MRC DTP project with @adamsgreenstein @stu_art_here & Ingo Schiessl, using state-of-the-art methods and models. Please share findaphd.com/phds/project/mr…
Well deserved! Congratulations!
Humbled and honored to be named the recipient of the 2025 Robert M. Berne Distinguished Lectureship
@APSPhysiology CVS Section.
Thanks to the many mentors, advisors, colleagues & friends.
@ucdavis, @UCDavisHealth, @MCIPUCD, @PTXatUCD, @MNCline
health.ucdavis.edu/news/head…
Congratulations, Dr. Walsh! Come and visit us in Rochester.
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Scott Earley retweeted
Check out our new offering. Great collaboration with Serysheva lab. @Irina52948708
biorxiv.org/content/10.1101/…
Scott Earley retweeted
Super exciting that this amazing work by our lab led by the brilliant @Jadeltaylor19 has been nominated! Please do vote if you’re able 🙌🏼
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We have a few more slots left. Please join us in sunny Tuscon! (its a dry heat…)
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I'm delighted to announce that the Earley Lab will be moving to @URMC Department of Pharmacology & Physiology as of August 1! We have multiple positions for postdocs, res. scientists, and Ph.D. students interested in vascular TRP channels, blood flow in the brain, and cSVDs.
Scott Earley retweeted
Want to save $150 to hear the latest research at #VASOSRC before it hits the journals? Register by June 23 and save your space: hubs.ly/Q02zWtyq0
