@AndyShih_Lab
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Neuroscientist, sorting out the brain's plumbing in health and disease.
Seattle, Washington
Joined February 2021
- Tweets224
- Following489
- Followers1.8K
- Likes362
Andy Shih retweeted
Happy to see this work finally published 🙌!! A team effort with @AndyShih_Lab!! We show that from birth to old age, #microglia 🧠 undergo striking shifts in morphology, complexity, and injury response. #liveimaging #neuroimmune #neonatalbrain #agingbrain
Physiological and injury-induced microglial dynamics across the lifespan dlvr.it/TLxvmH
It is debated whether poor #blood flow underlies white matter loss in #aging. Our recent study in aged mice supports this idea: Impaired drainage through rare, deep-reaching #venules causes mild #hypoperfusion that triggers inflammation and demyelination.
nature.com/articles/s41593-0…
Andy Shih retweeted
Groundbreaking scientific discoveries don’t happen in isolation.
Michelle Gray, PhD, SfN Program Committee member, shares how you can enhance your research through valuable exchange w/ the scientific community at #SfN25.
Submit your abstract today!
🔗 bit.ly/4juLSLs
Very happy to share @stephkbeee's study in @PNASNews on the effects of capillary injury in the brain. Protect those heads!
Stephanie is starting her own lab at @CUAnschutz soon and excited to see her research grow!
Ever wonder if small injuries to capillaries have lasting consequences? Our work exploring this question is now out! None of this would have been possible without the help of some brilliant minds - @NielsonCara @sosamariaj @OrlaBonBon @AndyShih_Lab pnas.org/doi/10.1073/pnas.23…
Growth hormone acts on #pericytes, stimulating #angiogenesis and supporting #oligodendrocyte survival & growth after neonatal hypoxia.
An impressive study by the Mei Lab (cell.com/neuron/fulltext/S08…) in @NeuroCellPress. Preview written with @vcoelhosantos (cell.com/neuron/abstract/S08…)
What makes cerebral white matter more vulnerable with age? In this mouse study, we show that large and rare venules are bottlenecks for blood flow in the white matter. Deep branches of these venules are constricted with age, leading to reduced blood flow.
biorxiv.org/content/10.1101/…
An epic study by Stefan Stamenkovic and Nicolas Weiterman, with collaborators @franca_schmid (in silico modeling), Jack Waters, Kevin Takasaki from @AllenInstitute (3-photon), @HannahCBennett7 @yongsookimlab (light-sheet imaging), @stephkbeee @sosamariaj @JennyYuandongLi
Andy Shih retweeted
This mini review was a fun one for @sosamariaj and I where we dove into the mysteries of brain perivascular fibroblasts! Thank you to @AndyShih_Lab for guidance on this one! Please enjoy 😊!
frontiersin.org/articles/10.…
Mural cell calcium imaging revealed a de-coupling of calcium activity from vessel dynamics in transitional vessels. So, mural cells are signaling but fail to translate these signals into contraction/relaxation.
Capillary injuries and regression are hallmarks of many neurological diseases, but they are exceedingly small and evade detection by most clinical imaging. Studies in animal models can help us understand how small injuries produce outsized effects through their remote actions.
Another wonderful study led by post-doc and K99/R00 fellow @stephkbeee, supported by PhD student @NielsonCara and lab manager @sosamariaj.
@stephkbee is on the faculty job market. A world-class two-photon imager and so much more!
It's all connected... In this study, we show that tiny injuries created deep in the brain's capillary bed can contribute broadly to blood flow impairment by constricting upstream supply vessels. biorxiv.org/content/10.1101/…
Focal capillary injuries were made using precision laser ablation, and the effects of these injuries were carefully monitored across vascular zones.
Andy Shih retweeted
MARK YOUR CALENDAR: The @dfg_public CRC1366 will host the "Vascular Control of Organ Function" meeting in Mannheim in May 2024. Exciting program with diverse contributions from different fields of angiocrine research. Registration will open in October at SFB1366.de .
Excited to be collaborating with @Mishra_CBF_Lab on this newly funded project to study pericytes roles in Alzheimer's disease. An amazing mentor and training environment.
Pls RT!
We are hiring RAs & postdocs to study pericyte function and neurovascular coupling mechanisms in physiology & dementia pathology.
*Funded positions!
*Join a fantastic team!
*Live in beautiful Portland, OR!
tinyurl.com/MishraLabRA
tinyurl.com/MishraLabPD
DM/email for info.
The O'Herron lab is highly recommended for trainees interested in innovative approaches to image and manipulate brain vasculature.
This quoted post is unavailable.
Andy Shih retweeted
We team up with @drew_lab_nvc to examine anatomical and functional changes in aged mouse brain. We found that aging induces selective regional vascular and pericyte degeneration, slowed NVC response, and lower oxygen carrying capacity.
biorxiv.org/content/10.1101/…
This technique makes it almost effortless to label neurons for in vivo calcium imaging and neurovascular coupling studies. New study from @Prakash3Photon lab.
frontiersin.org/articles/10.….
AAV tool from @VivianGradinaru @DevermanLab.
This just dropped - our evaluation of intravenous injection of GCaMP. It works well & we tested sensory responses out to 34 weeks post-injection :) doi.org/10.3389/fnins.2023.1…
The first review from the @vcoelhosantos lab! Surprisingly little known about how early life hypoxic events affect cerebrovascular function and resilience in adulthood.
Does perinatal intermittent hypoxia affect cerebrovascular network development?
Unfortunately, we don’t have the answer yet but we have a hypothesis! @AndyShih_Lab
#neonatal #braininjury #cerebrovascular #intermittenthypoxia
Check the preview 👇
karger.com/dne/article/doi/1…
