@timluongo
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Early‑stage Biotech Advisor | Founder & Principal @ BridgeLine Translational Partners | Discovery, Nonclinical & Portfolio Strategy • Investor Readiness
Joined August 2015
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I am excited to share our most recent work from the
@baurlab published @nature revealing SLC25A51 expression regulates mitochondrial NAD+ levels and encodes the mammalian mitochondrial NAD+ transporter. #NAD #mitochondria #metabolism
nature.com/articles/s41586-0…
Tim Luongo retweeted
Our new study describing a "potential" mitochondrial glutathione transporter (SLC25A39 and 40). Congrats to all of my amazing lab members and collaborators involved in this work for the last 4 years. @RockefellerUniv @Nature @TriIMDPhD
nature.com/articles/s41586-0…
Tim Luongo retweeted
What a journey! I can finally share with the world the work I’ve been able to accomplish during the time of my postdoctoral training.
🧵
authors.elsevier.com/c/1doI7…
Therapeutic Discovery at StrideBio is hiring! Apply if you are interested in developing gene therapies for cardiovascular disease.
stridebio.applicantpool.com/…
Tim Luongo retweeted
In the failing heart, short chain fatty acids (SCFA) are more readily oxidized than ketones & represent an unexplored source of energy production. Read more: ow.ly/moXN50EEwPH #AHAJournals @DougLewandowski
Tim Luongo retweeted
Excited to share our recent work spearheaded by @AnnaGar33 that show an important role for hepatic FOXO transcription factors in driving stress-induced hyperglycemia and insulin resistance in mouse models of trauma @pennsurgery @PennIDOM @MolMetab
sciencedirect.com/science/ar…
Tim Luongo retweeted
Congrats to Sarmistha Murkherjee for her recent study revealing that SIRT3 is required for liver regeneration and that the benefits of boosting #NAD are independent of sirtuins.
insight.jci.org/articles/vie…
Tim Luongo retweeted
We are excited to share the first paper from our lab @NatMetabolism. We discovered that mitochondrial NADP+ is essential to enable proline synthesis and reveal the first example of mammalian proline auxotrophy nature.com/articles/s42255-0…. 1/12
Tim Luongo retweeted
Ablation of Nampt in AgRP neurons leads to neurodegeneration and impairs fasting‐ and ghrelin‐mediated food intake faseb.onlinelibrary.wiley.co…
Tim Luongo retweeted
Our new paper is out online! We uncovered a surprising ability of the adult heart to withstand defects to the mtDNA maintenance machinery. The developed vs. developing heart respond very differently to mito dysfunction. #mitochondria #heart
journals.physiology.org/doi/…
Tim Luongo retweeted
We had a blast writing this mini-review on the recent discovery of the mito-NAD transporter in mammalian cells, & what it could mean for the broader field of NAD biology. @alexjbott @Yeyunouyang @giuliosf @KoryLab @timluongo @e_girardi @TrendsBiochem
authors.elsevier.com/a/1ccL3…
Tim Luongo retweeted
D-day alert: Nature Cardiovascular Research site is now live! nature.com/natcardiovascres/
To all my followers who have cardiovascular and blood biology @❤️ and 'in their veins', please follow us @NatureCVR We're open for submissions in mid-April!
Tim Luongo retweeted
The RECOVERY Data Monitoring Committee reviewed data on patients randomised to convalescent plasma vs. usual care. The preliminary analysis based on 10,406 randomised patients with 1873 reported deaths shows no significant difference in the primary endpoint of 28-day mortality.
Tim Luongo retweeted
#NatMetabPicks | Reporting in @nature, Xiaolu Cambronne (@UTAustin), @JosephABaur & @timluongo (@Penn) identify the mitochondrial NAD+ transporter
nature.com/articles/s41586-0…
Tim Luongo retweeted
Excited to finally share my postdoctoral work and latest manuscript from the @EricVerdin Lab and @BuckInstitute exploring how senescent cells promote tissue #NAD decline during ageing via the activation of CD38+ macrophages. nature.com/articles/s42255-0…
Tim Luongo retweeted
Online now! Nutritional modulation of heart failure in mitochondrial pyruvate carrier–deficient mice dlvr.it/RkNjRV
Tim Luongo retweeted
Attention all #mitochondriacs
Check out our latest work in @SciReports where we describe a method for quantifying mitochondrial content and intrinsic OXPHOS efficiency using mass spectrometry, respirometry and fluorescence nature.com/articles/s41598-0….
See 👇 for details. 1/
Tim Luongo retweeted
Yes - he wrote to me and sent me this article a few weeks ago too! He really did discover the shuttle 60 yrs ago. I sent him the recent NAD transport papers from @nora_kory @DMSabatini @BaurLab @LACambronne. He seemed happy to see this is a major area of research in 2020.
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Tim Luongo retweeted
1/6 Thrilled to share the first project from my PhD in the @AranyLab out today in @ScienceMag, co-led by @cholsoon_jang (while @ Rabinowitz Lab) and w/ Dr. David Frankel and Dr. Matthew Hyman of the EP section @PennMedicine. #cardiotwitter science.sciencemag.org/conte…
Tim Luongo retweeted
Thanks @k8weeks @OzCvA @JMCCardiology for the invite & support - looking forward to the session!
Excited to announce this week's #ISHR webinar, featuring Prof Bin Zhou & Dr @VagnozziRJ
Cardiomyocyte regeneration or cardiac repair? Insights from lineage tracing
2pm AEDT Wed 14th Oct (Tues in 🇺🇸)
Register bit.ly/3nvqk52
@OzCvA @JMCCardiology @ISHR_NAS @ECI_ISHR
