@KFW_Lab

Associate Professor - Wake Forest University School of Medicine. Research Focus - #Mitochondria and cancer

 Winston-Salem, NC
fisherwellmanlab.com/
Joined August 2018
  • Tweets1.7K
  • Following960
  • Followers1.8K
53Media
Excited to announce that our work exploring the bioenergetics of blood cancer is now published at @eLife #Mitochondria, #CancerMetabolism elifesciences.org/articles/6… See original tweetorial for detailed summary and below for a few broader points.

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia

Across a physiological span of ATP-free energy, leukemic mitochondria primarily consume, rather than produce, ATP.

elifesciences.org
Kelsey Fisher-Wellman, PhD@KFW_Lab
24 May 2021
Excited to share the lab’s first ever pre-print exploring the specific role of OXPHOS in AML! What we found might surprise you. Click👇 for paper access and please don't hesitate to provide some feedback. See🧵for details. @researchsquare researchsquare.com/article/r…

Intrinsic OXPHOS limitations underlie cellular bioenergetics in leukemia.

Typified by oxidative phosphorylation (OXPHOS), mitochondria catalyze a wide variety of cellular processes seemingly critical for malignant growth. As such, there is considerable interest in target...

researchsquare.com
8
29
2
114
📢Collaborative Project between our lab and the Jensen Lab at UNC-CH exploring the role of the #Mitochondria in MEK inhibitor cardiotoxicity -- Manuscript out today in @ScienceAdvances - science.org/doi/10.1126/scia…

The MEK inhibitor trametinib incurs mitochondrial injury and induces innate immune responses in the...

Cardiotoxicity induced by trametinib is associated with mitochondrial damage and resulting immune activation.

science.org
1
1
12
2,356
Looking forward to talking mitochondria and cancer in Glasgow in a few weeks! 👇
Mitoworld.org@mitoworld_org
Jun 8
Replying to @mitoworld_org
Don't miss the related roundtable during the Cell Press Symposium: Multifaceted Mitochondria (June 21-23)!
9
1,004
Kelsey Fisher-Wellman, PhD retweeted
Mitoworld.org@mitoworld_org
Jun 8
New MitoBlog features @Cell_Metabolism commentary on cancer and #mitochondria insights & new #MitoCancerAtlas project! ⁉️See Q&A with @tommacvicar @GreavesLab @KFW_Lab @GFREED & S. Tait @CRUK_SI mitoworld.org/cancer-as-a-wi… #UMDF #mitoscientists #cancerresearch @Payam78 #mitocancer
1
1
3
300
Collaboration between our group and the Tirosh lab exploring a novel mTOR activator (they devloped) in combination with ixazomib for treatment of Acute Myeloid Leukemia! - link.springer.com/article/10…

AcTor, a novel mTOR stimulator, potentiates ixazomib for the treatment of acute myeloid leukemia

Molecular Cancer - mTORC1 activity is oncogenic. However, in the presence of chemotherapy, suppression of mTORC1 is cytoprotective. mTOR suppression requires an intact tuberous sclerosis complex...

link.springer.com
4
4
301
New review from our group taking a critical look at OxPhos as a cancer target......and suggestions for where the field goes next. Published in @Biochem_Journal portlandpress.com/biochemj/a…

Re-evaluating the rationale for targeting oxidative phosphorylation in acute myeloid leukemia

Abstract. Targeting mitochondrial oxidative phosphorylation (OxPhos) has become a recurring strategy in the treatment of cancer, particularly in acute myeloid leukemia (AML). Early reports suggested...

portlandpress.com
8
9
1,986
Kelsey Fisher-Wellman, PhD retweeted
FUTURUMCareers
@FUTURUMCareers
Apr 28
Blood cancers, such as leukaemia, are challenging to treat. At @wakeforestmed in the US, Dr Kelsey Fisher-Wellman @KFW_Lab is investigating how mitochondria in cancerous cells differ from those in healthy cells. futurumcareers.com/cancer-bi…
2
4
14
105,887
Kelsey Fisher-Wellman, PhD retweeted
FUTURUMCareers
@FUTURUMCareers
Apr 28
In this podcast, Dr Kelsey Fisher-Wellman @KFW_Lab from @wakeforestmed shares how he has become a successful cancer biologist despite coming from an unconventional educational background: futurumcareers.com/cancer-bi…
2
1
79,309
Kelsey Fisher-Wellman, PhD retweeted
FUTURUMCareers
@FUTURUMCareers
Apr 28
Our latest collection of Spanish resources (including article, activity sheet, animation, podcast and PowerPoint) explore cancer biology with Dr Kelsey Fisher-Wellman @KFW_Lab at @wakeforestmed: futurumcareers.com/cancer-bi…
1
3
857
Kelsey Fisher-Wellman, PhD retweeted
FUTURUMCareers
@FUTURUMCareers
Apr 28
In our latest collection of educational resources, we explore cancer biology with Dr Kelsey Fisher-Wellman @KFW_Lab from @wakeforestmed. Learn all about his exciting research and inspiring career journey: futurumcareers.com/cancer-bi…
1
2
146
New publication from our group. We examine the primary functional consequences of mtDNA mutations across major organ systems. Spoiler: the cumulative mutational burden broadly phenocopies a complex I deficiency. cell.com/iscience/fulltext/S…

Accumulated mtDNA mutations are linked to specific impairments in NADH-linked respiration

Biochemistry; Genomics; Molecular biology

cell.com
23
91
7,239
Kelsey Fisher-Wellman, PhD retweeted
Lyssiotis Lab
@LyssiotisLab
20 Nov 2025
Honored to be listed in Clarivate’s top 1% of cited scientists. I know rankings and citation metrics raise valid concerns about how we evaluate science… but I still feel proud of the work my team and collaborators have done together 💪🏼 #GoBlue 〽️
U-M Rogel Cancer Center@UMRogelCancer
19 Nov 2025
🎉Congrats to 6 Rogel researchers named to @Clarivate #HighlyCited2025 list 💙💛 · Arul Chinnaiyan #ChinnaiyanLab · Costas Lyssiotis @LyssiotisLab · Eric Martens · Alexey Nesvizhskii @nesvilab · Thomas Schmidt · Weiping Zou
7
48
6,406
Big shoutout to the folks over at @FUTURUMCareers for highlighting our work exploring the role of the mitochondria in blood cancers. It was an absolute pleasure to work with such a great team! futurumcareers.com/cancer-bi…

Could oddly behaving mitochondria hold the key to treating leukaemia? - Futurum

Dr Kelsey Fisher-Wellman is comparing mitochondria in healthy and cancerous cells so that treatments for leukaemia can target these differences.

futurumcareers.com
2
2
16
1,276
Kelsey Fisher-Wellman, PhD retweeted
Lydia Lynch@lynchielydia
28 Jul 2025
This was a labor of love requiring lots of teamwork over years, repeating in 3 locations! Thanks to all the lab over the years, giving their time generously to this team project, & our wonderful collaborators. The source of fat matters for anti-tumor immunity 🐄🐖🧈🌴🫒🥥
Nature Metabolism
@NatMetabolism
25 Jul 2025
The source of dietary fat influences anti-tumour immunity in obese mice go.nature.com/4o2w4CJ
9
47
4
217
20,496
Kelsey Fisher-Wellman, PhD retweeted
Martin Picard
@MitoPsychoBio
24 Jul 2025
GDF15 is the best biomarker of energetic stress and energy resistance (éR) New paper showing that GDF15 is on average elevated people with diagnoses of schizophrenia (+61%), bipolar disease (+56%), and major depressive disorder (+82%) Consistent with the notion that mental health disorders are energetic disorders @ChrisPalmerMD sciencedirect.com/science/ar… @janellison @Metabolic_Mind
20
38
8
206
20,454
Kelsey Fisher-Wellman, PhD retweeted
Muir Lab@Muir_Lab
19 Jul 2025
Super excited to share new review on metabolic stress and adaptations in pancreatic cancer to these stresses from @ColinSh21573670 jci.org/articles/view/191940 1/6
1
8
32
2,261
Kelsey Fisher-Wellman, PhD retweeted
Brett Chrest@Chrest_brett
4 Jun 2025
📢New @KFW_Lab paper out! AML mitochondria remain unperturbed & phenotypically stable under diverse nutrient conditions. And rather than specific nutrients or physiological relevance, AML cell proliferation is influenced by the complete nutrient profile 👉 cancerandmetabolism.biomedce…

Impact of physiological media on acute myeloid leukemia bioenergetics and cell proliferation

Cancer & Metabolism - Increasing emphasis has been placed on improving the physiological relevance of cell culture media with formulations such as Human Plasma-Like Medium (HPLM). Given that...

link.springer.com
5
11
2
41
5,843
Kelsey Fisher-Wellman, PhD retweeted
Gregory Ducker@gsducker
29 May 2025
New paper alert! Huge congrats to my graduate student @jn_velascosilva on his first author publication in physiological reports physoc.onlinelibrary.wiley.c… 1/n

Loss of hepatic autophagy induces α‐cell proliferation through impaired glutamine‐dependent...

Autophagy, the highly conserved process of protein and organelle degradation, is suppressed in the liver by obesity and metabolic dysfunction-associated fatty liver disease and associated with the...

physoc.onlinelibrary.wiley.com
5
11
34
3,971
Kelsey Fisher-Wellman, PhD retweeted
Phillip J White PhD@phillipwhite14
1 May 2025
The Sable Award lecture at METPHYS2025 was really remarkable! Tremendous congratulations to this years exceptional member of our community @KivancBirsoy
10
9
2
92
6,764
Kelsey Fisher-Wellman, PhD retweeted
Dan Lark@ERM_Lab
23 Apr 2025
Final version of our new paper "Mapping Organism-wide Single Cell mRNA Expression Linked to Extracellular Vesicle Biogenesis, Secretion, and Cargo" is now available Open Access. academic.oup.com/function/ar…

Function

journals.physiology.org
1
3
14
1,408
Kelsey Fisher-Wellman, PhD retweeted
Muir Lab@Muir_Lab
21 Apr 2025
Excited to share new report from collaborative work from @DelgoffeLab and @PatrickJonker4 from our team on a novel metabolic suppressor of T cell function in tumors! rdcu.be/eiyIa 1/
3
13
2
40
7,257
Load more