@BaurLab

Baur Lab in @pennIDOM and @UPennPhysiology at @pennmedicine. Our lab studies how changes in signaling and metabolism influence mammalian aging and disease.

 University of Pennsylvania
Joined September 2020
  • Tweets26
  • Following146
  • Followers817
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Great work, Karthi @KarthikeyaniC and Melanie @dr_ohsopretty! Check out our collaborative work with the Rabinowitz lab in Cell Metabolism about NAD precursors in the gut microbiome. @Cell_Metabolism cell.com/cell-metabolism/ful… #microbiome #NAD

NAD precursors cycle between host tissues and the gut microbiome

Chellappa et al. show that the gut microbiome primarily obtains its NAD from host-derived circulating nicotinamide. Deamidation of nicotinamide to nicotinic acid by microbes maintains circulating...

cell.com
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Sam is a junior at @cabriniuniv and a former #PennSUIP intern (‘22). Sam studied NAD metabolism of electron transport chain-related diseases with @BaurLab @PennIDOM. Sam shares why he chose #PennSUIP. Reminder: SUIP app deadline is Feb 1! Visit: med.upenn.edu/idealresearch/…
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Sharing the load: @FrancescaGazza5 examines @BaurLab @KarthikeyaniC @Cell_Metabolism work where tracking NAD metabolism reveals symbiotic relationship-#microbiota uses host nicotinamide to generate NAD &in return produces nicotinic acid for host NAD biosyn cell.com/cell-host-microbe/f…

Sharing the load in NAD metabolism

Recently in Cell Metabolism, Challapa et al. used isotope labeling to track NAD metabolism in host tissues and the gut microbiota. They describe a symbiotic relationship in which the gut microbiota...

cell.com
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Impressive work by @Lenka_Dohnal @nitaidean @sellmyerlab @FitzGerald__Lab @PSUmetabolomics @BaurLab @AmberAlhadeff @Helfrich_lab @MaayanLevy_Lab See thread by @ThaissLab Hope they have a @redcube link for those with access issues nitter.cf/ThaissLab/status/16030…
Christoph Thaiss@ChristophThaiss
14 Dec 2022
We are excited to share our new work @Nature, led by @Lenka_Dohnal, uncovering a gut-brain pathway that regulates the motivation for #exercise. (1/7) nature.com/articles/s41586-0…
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Happy Holidays from the Baur Lab! If you zoom in, you can see A51 importing NAD to the MitoLawn!
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Amazing work! What will @KarthikeyaniC do next?!
Penn IDOM@PennIDOM
6 Dec 2022
New work published in @Cell_Metabolism from @BaurLab detailing the interplay between host and gut microbiome for #NAD metabolism cell.com/cell-metabolism/ful…

NAD precursors cycle between host tissues and the gut microbiome

Chellappa et al. show that the gut microbiome primarily obtains its NAD from host-derived circulating nicotinamide. Deamidation of nicotinamide to nicotinic acid by microbes maintains circulating...

cell.com
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Replying to @BaurLab
@BaurLab representing in the @PennIDOM Halloween party 🎃👻 @CEPerry230
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Preprint of our work on understanding how #NAD declines with age is out. A collaborative effort by @BaurLab and @dr_ohsopretty in Rabinowitz lab. Check it out if you like aging and metabolism. NAD flux is maintained in aged mice. researchsquare.com/article/r…

NAD+ flux is maintained in aged mice

NAD+ is an essential coenzyme found in all living cells. NAD+ concentrations decline during aging, but whether this reflects impaired production or accelerated consumption remains unclear. Here we...

researchsquare.com
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Congrats to Deyang Yu, @NRichar_ @garacreen @michaelamRD @pak_heidi, our collabs @cholsoon_jang @BaurLab @MaleckiKristen and many others for contributing one of the Best of Cell Metabolism 2021 papers! And thanks to @Cell_Metabolism for this recognition pubmed.ncbi.nlm.nih.gov/3388…
Cell Press@CellPressNews
13 Jul 2022
Read popular papers published in @Cell_Metabolism. Download the free Best of Cell Metabolism 2021. hubs.li/Q01gGFj50
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The Baur Lab is looking for several post-docs to join our team at the University of Pennsylvania. If you like mitochondria, NAD, and heart research, or want to try something new...see our job posting here! tinyurl.com/5e8d5c7m
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Congratulations Caroline!! We are so proud of you!
Cancer Biology Program @Penn@PennCBP
25 Aug 2022
Huge congrats to Caroline Perry from the Baur Lab who just received an NOA for her F31 proposal!! @CEPerry230 @BaurLab @CAMBUpenn #PennCancerResearch
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Excited to share our recent work led by @KarthikeyaniC (Baur Lab) and @dr_ohsopretty (Rabinowitz Lab) identifying sources of microbial NAD and showing that circulating nicotinamide is shared with the gut microbiome. @wenyun_lu @ThaissLab #NAD #microbiome biorxiv.org/content/10.1101/…

NAD precursors cycle between host tissues and the gut microbiome

Nicotinamide adenine dinucleotide (NAD) is an essential redox cofactor in both mammals and microbes. Here we use isotope tracing to investigate the precursors supporting NAD synthesis in the gut...

biorxiv.org
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Congrats to Sarmistha Murkherjee for her recent study revealing that SIRT3 is required for liver regeneration and that the benefits of boosting #NAD are independent of sirtuins. insight.jci.org/articles/vie…
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We had a blast writing this mini-review on the recent discovery of the mito-NAD transporter in mammalian cells, & what it could mean for the broader field of NAD biology. @alexjbott @Yeyunouyang @giuliosf @KoryLab @timluongo @e_girardi @TrendsBiochem authors.elsevier.com/a/1ccL3…
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Check out the @NatureNV written by Ulf Beier and @CEPerry230, a grad student in our lab, summarizing work from the @hongbo_chi lab
Caroline Perry@CEPerry230
24 Feb 2021
Excited to share our @NatureNV article about the incredible work by the Hongbo Chi Lab at @StJudeResearch showing that lipid metabolism potentiates regulatory T cells in the tumor microenvironment. nature.com/articles/d41586-0… #metabolism #immunology #tcell @nature
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#NatMetabPicks | Reporting in @nature, Xiaolu Cambronne (@UTAustin), @JosephABaur & @timluongo (@Penn) identify the mitochondrial NAD+ transporter nature.com/articles/s41586-0…

SLC25A51 is a mammalian mitochondrial NAD+ transporter

Nature - SLC25A51 is identified as a transporter of intact NAD+ into mammalian mitochondria and is required to maintain the mitochondrial NAD+ pool and respiratory function.

nature.com
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SLC25A51 is a mammalian #mitochondria-l #NAD+ transporter. @timluongo @LACambronne @CambronneLab @BaurLab buff.ly/3mItNwq
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Check out a preprint of our latest work investigating NAD metabolism in aging. This work was co-led by @dr_ohsopretty and @KarthikeyaniC. NAD+ flux is maintained in aged mice researchsquare.com/article/r…

NAD+ flux is maintained in aged mice

NAD+ is an essential coenzyme found in all living cells. NAD+ concentrations decline during aging, but whether this reflects impaired production or accelerated consumption remains unclear. Here we...

researchsquare.com
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Excited to return to @BMB_PSU and @PSUScience to share my scientific updates with the community that helped shape my career in the beginning. And it’s open to the public!
Penn State BMB@BMB_PSU
15 Sep 2020
Our Department will be opening up many of its Fall 2020 seminars on Zoom to people beyond the @penn_state community. ✅Next up: Dr. Melanie McReynolds (@Princeton) ✅Monday, September 21, 4pm, ✅“NAD+ Flux is Maintained in Aged Mice” 🐭 ✅Hosted by Dr. @WendyHannaRose
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Today at 4 PM EST, @KarthikeyaniC from our lab presents her work, "Circulating nicotinamide feeds NAD+ biosynthesis by the gut microbiome", in the @PennIDOM TRIP seminar series here at Penn! bluejeans.com/119275711
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