@DougLewandowski
Joined June 2019
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Doug Lewandowski retweeted
Circulation@CircAHA
6 May 2021
In the failing heart, short chain fatty acids (SCFA) are more readily oxidized than ketones & represent an unexplored source of energy production. Read more: ow.ly/moXN50EEwPH #AHAJournals @DougLewandowski
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News from our lab and the result of great collaborations with the folks at Columbia in NY and the Schulze lab at U. Jena in Germany
Nature Metabolism
@NatMetabolism
11 Jun 2019
Lewandowski's lab show that long-chain acyl coenzyme A is depleted in failing hearts. Restoring it via #ASCL1 activation and mechanical unloading attenuates cardiac remodeling and failure. @CircAHA. #NatMetabPicks ahajournals.org/doi/10.1161/…

Preservation of Acyl Coenzyme A Attenuates Pathological and Metabolic Cardiac Remodeling Through...

Background: Metabolic remodeling in heart failure contributes to dysfunctional lipid trafficking and lipotoxicity. Acyl coenzyme A synthetase-1 (ACSL1) facilitates long-chain fatty acid (LCFA) uptake...

ahajournals.org
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