dad - senior scientist at https://xitter.cf/t.co/yahvMgGrLa - psychedelics and other fun stuff - aspiring urban homesteader - https://xitter.cf/t.co/CaARmkGGQn
Greenville, SC
Joined March 2018
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🍄 Our first sypres.io living systematic review and meta-analysis on psilocybin for depression is out now in @NatMentHealth. Here's what we found and the open science infrastructure we built to support it: 🧵
Open-Access Link: rdcu.be/fbU5V
Parker Singleton retweeted
Are psychedelics anti-inflammatory!?
I am beyond excited to present the first systematic review and meta-analysis of the immunomodulatory effects of serotonergic psychedelics!
sciencedirect.com/science/ar…
Parker Singleton retweeted
✨🧘🍄 New study 🍄🧘✨ Many people think that meditation & psychedelics might have similar effects. Our new study examines how beliefs & cognitive processes might be similar or different in consistent meditators versus psychedelic users
Share widely!
Parker Singleton retweeted
Excited that this paper, "Highly replicable multisite patterns of adolescent white matter maturation", has now been published in Neuron! It may be found at cell.com/neuron/fulltext/S08…. To freely access the paper for the next 50 days, please use this link: authors.elsevier.com/c/1nxdd…
Diffusion MRI (dMRI) is a powerful tool to study white matter maturation. In our new preprint, we process and distribute a new resource of >24,000 ABCD dMRI scans using open source tools! We then evaluate how methods shape inferences about development.
🔗 bit.ly/3QMLG0K
Now out in NPP (open-access): doi.org/10.1038/s41386-026-0…
🍄 Our second installment of sypres.io, a living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵
medrxiv.org/content/10.64898…
Out now in NPP: bsky.app/profile/bsevchik.bs…
🍄 Our second installment of sypres.io, a living systematic review and meta-analysis on MDMA for PTSD is now live on medRxiv. Here's what we found and how we built upon our open science infrastructure to support it 🧵
medrxiv.org/content/10.64898…
Parker Singleton retweeted
The most important briefings of the day.
Karl Deisseroth, professor of bioengineering and of psychiatry and behavioral sciences, shares the news of his Nobel Prize with his kids.
Parker Singleton retweeted
New paper, by me & @r_ehrenkranz (former postdoc at @TheYadenLab, now asst prof of biostats at @NorthwellHealth): We validated & shortened the Persisting Effects Questionnaire (PEQ), used to measure pos and neg changes after psychedelic exp-144 items to 14, w/ 3 stand-alone items
New paper – Validating and Creating a Short-Form of the Persisting Effects Questionnaire: A Measure of Positive and Negative Outcomes from Psychedelic Experiences
The Persisting Effects Questionnaire (PEQ) is a measure of self-reported positive and negative effects from psychedelic experiences. While commonly used, the PEQ has never been formally validated, and is time-intensive and complex for both participants and researchers.
Using a multi-study approach, CPCR researchers created and validated the Persisting Effects Questionnaire – Short Form (PEQ-SF), a scale that is more easily understood and reduces burden for study teams and participants.
Read the paper here: journals.sagepub.com/doi/10.…
4-arm psilocybin for depression trial out of Pakistan: geneticsmr.com/index.php/gmr…
An extraordinary @Nature paper has just landed from the lab of @Sergiu_P_Pasca at @Stanford - led by Konstantin Kaganovsky. They have found a way to create "xenocortical mice" which have ~92% of their cortex occupied by a cortical organoid derived from human stem cells. This human-derived cortical graft integrates deeply with the host nervous system, supporting organised neural activity and behaviour.
This study is a milestone in synthetic biology and chimera research. It has the potential to generate multiple medical breakthroughs by providing an enhanced biological model of human brain tissue that allows behavioural as well as neural and genetic assays.
The Stanford team have been exceptionally thorough and proactive in addressing ethical concerns that comes from this frontier work. But their pioneering work nonetheless raises many open questions: are the xenocortical mice conscious? Do they have any human-like properties of consciousness or cognition?
@NitaFarahany and I will be addressing some of these questions in a forthcoming commentary - where we'll also offer an ethically-informed roadmap to guide this important research as it progresses. In this context, "pacing the frontier" really does make sense 😉
Read the Stanford @nature paper here, and buckle up. It's wild. nature.com/articles/s41586-0…
Parker Singleton retweeted
we’re losing the ancient texts
WAH-PAH!
This morning, boogie boarder Ethan explained the high surf conditions on the OC coast to @JSarkissian.
Parker Singleton retweeted
See our RCT published today @JAMAPsych
Serial Ketamine Infusions for Treatment-Resistant Bipolar Depression (TRBD)
In TRBD, adjunctive IV ketamine was well tolerated and associated with significant antidepressant effects.
@UofTPsych @KBI_UHN @UHN
jamanetwork.com/journals/jam…
Parker Singleton retweeted
In neuroscience, global workspace theory holds that thoughts become consciously accessible when they enter a privileged workspace that’s broadcast across the brain.
Using a new interpretability technique, we found something similar in Claude: the J-space. anthropic.com/research/globa…
Parker Singleton retweeted
Awesome new work by Taylor Salo and @singletonion — a small but valuable test-retest dataset comparing single & multi-echo fMRI. Completely open + fully processed!!!!
New dataset out in Data in Brief 🧠
We're releasing an open, test-retest neuroimaging dataset built for directly comparing single-echo vs. multi-echo fMRI, head-to-head, in the same people.
🔗 sciencedirect.com/science/ar…
Huge thanks to all of the co-authors! This data was collected as part of an internal initiative and later brought to the public via a hackathon! @sattertt
Full derivatives are included too: MRIQC, fMRIPrep, tedana, and XCP-D outputs on OpenNeuro, plus Nilearn outputs on NeuroVault.
🔗 openneuro.org/datasets/ds007…
Why phase data matters: it's almost never shared in fMRI studies, but it opens the door to better thermal noise removal, phase-based confound extraction, phase regression, complex ICA, and complex-valued modeling — none of which are standard in pipelines like fMRIPrep yet.
The extras that make this dataset unusual:
– magnitude AND phase reconstruction (phase is rarely released in fMRI data)
– noRF ("noise-only") volumes — all scan parameters kept, no RF pulse — great for thermal-noise denoising like NORDIC
– multiple field map types