silvoLab retweeted
Our paper is out in @Nature! Extrachromosomal DNA molecules huddle together in cancer cells to activate oncogene expression (which we call ecDNA hubs). A great collaboration with @KatieEYost, @HowardYChang, @549nm, Zhe Liu, and others. (1/10) nature.com/articles/s41586-0…
silvoLab retweeted
Our study "Individualized VDJ recombination predisposes the available Ig sequence space" is now published in Genome Research 🥳
genome.cshlp.org/content/ear…
Congrats @rlyhighvariance et al.!
1/11 Did you ever wonder whether individuals have the same probability of generating a given antibody sequence? Turns out, they do not – not even twins!
We showed that humans – including monozygotic twins – have unique VDJ recombination rules. biorxiv.org/content/10.1101/…
silvoLab retweeted
1/Excited to share my first author publication where we create split-engineered base editors (seBEs). Here, we place base editors under the control of a small-molecule to regulate the timing of genome editing and decrease off-target effects. To achieve it: nature.com/articles/s41589-0…
silvoLab retweeted
Accepted manuscript strongly suggesting that apparent SARS-CoV-2 reads that appear to be integrated in the human genome, are in fact an artefact of library preparation.
frontiersin.org/articles/10.…
silvoLab retweeted
Do you want to explore basic research but also clinical practice? The IRCM's Master's degree in cellular and molecular medicine (MCM) is for you! ircm.qc.ca/en/studies-and-tr…
silvoLab retweeted
There is an important message here for today’s students. Techniques don’t matter. Questions do. Listing a set of techniques is silly because they will all be out of date in 10 years. But questions drive science forward.
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silvoLab retweeted
PhD positions (Early Stage Researchers) available within the H2020-MSCA-ITN project ROPES “ROle of ePitranscriptomics in diseasES”
Multiple locations, Europe
jobrxiv.org/job/department-o…
#ScienceJobs
silvoLab retweeted
If you’re having a hard time with glasses fogging or keeping your mask up over your nose, a simple bandaid does wonders. Learned it in the OR.
Feel free to share, it may save lives!
silvoLab retweeted
This new mink COVID-19 mutation story, which is making the rounds on Twitter is highly problematic. There are elements of truth in it but the reporting is completely irresponsible.
1/
berlingske.dk/nyheder/englis…
silvoLab retweeted
1/10 … Very excited to finally share the preprint of our work on DNA replication in mouse & human meiosis …
Big learning curve, lots of fun, and some cool discoveries along the way!
doi.org/10.1101/2020.09.23.3…
silvoLab retweeted
Great to see human disease validation of our decade old discovery of CTNNBL1-mediated AID nuclear transport! @car_rada @silvoLab @DrAnitaChandra @feebs
JCI - Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID jci.org/articles/view/131297…
silvoLab retweeted
Studies by Emily Law, Reuben Harris @HarrisLabUMN, Susan Ross @Susan_R_Ross and colleagues demonstrate that APOBEC3A catalyzes mutagenesis and promotes tumorigenesis in two different murine systems in vivo. bit.ly/3gOxzAH #GenomeStability #Solidtumors
silvoLab retweeted
I'm still in shock. Alekos was a real Scientist, with a passion for RNA editing and a curiosity for everything, bio and beyond. He was one of the most generous humans I know - with his time, his possessions, his mind. I wish I had said goodbye. Até sempre Alekos.
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silvoLab retweeted
It is finally out! If you want to know how to combat chronic pain by locking cFOS out of the nucleus, be sure to check out our new study. Thanks to all that helped me to make this happen, foremost @MFainzilber, @nico_panayotis, @StefanieAlber, & @TerenzioL science.sciencemag.org/conte…
silvoLab retweeted
Check out our review on RNA involvement the DNA damage response- nature.com/articles/s41576-0…
Learned all this from Dali- and thanks to Philipp and Pedro!
silvoLab retweeted
A new one from our team!!
Dissecting mutational mechanisms underpinning signatures caused by replication errors and endogenous DNA damage
Kudos to @xueqing_zou and @GeneChChKoh for all their efforts here!
biorxiv.org/content/10.1101/…
silvoLab retweeted
I wrote once again for @LRB about tetchy scientists and promising vaccine candidates. lrb.co.uk/the-paper/v42/n16/…
silvoLab retweeted
David's @davidmasp cool paper is out in @NatureGenet!
We identified a pattern of #mutation clustering in cancer #genomes, distinct from the known 'mutation showers'⛈️
We think one cause of such 'mutation fog'🌫️is DNA repair + APOBEC3A activity
read more nature.com/articles/s41588-0…
ALT We classified the diverse patterns of clustered mutagenesis in tumor genomes, which identified a new A3 pattern: nonrecurrent, diffuse hypermutation (omikli). This mechanism occurs independently of the known focal hypermutation (kataegis), and is associated with activity of the DNA mismatch-repair pathway, which can provide the single-stranded DNA substrate needed by A3, and contributes to a substantial proportion of A3 mutations genome wide.
silvoLab retweeted
I've heard that tweeted papers are cited more often.
nature.com/articles/s41588-0…