kevbrick (@kevbrick) profile picture
Bethesda, MD, USA
Joined August 2008
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Woohoo! Our paper on DNA replication in meiosis is published online today in @CellCellPress (authors.elsevier.com/a/1dO%7…).
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**ONLINE NOW!** @hbernstein16 and I are delighted that our paper using Cryo-EM and in vivo assays to understand outer membrane protein folding has found a home at Cell! @CellCellPress Here is a free access link to the article: authors.elsevier.com/c/1el7U… 1/3 cell.com/cell/fulltext/S0092…
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Online now! Combining a new approach for locating replication origins in mammalian tissues, with maps of replication timing and a model for genome-wide replication, reveals differences in the male meiotic replication program bit.ly/2UEqZXY
In addition to the findings we broadcast in our preprint (xitter.cf/kevbrick/status/130912…), we map the origins of replication in ES cells. Cell work is new for us, but it really helped to validate our approach and to highlight the diversity of how replication initiates across cell types.
1/10 … Very excited to finally share the preprint of our work on DNA replication in mouse & human meiosis … Big learning curve, lots of fun, and some cool discoveries along the way! doi.org/10.1101/2020.09.23.3…
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We also snuck in a new figure exposing the cool internal details of our in-silico replication models to quantify aspects of replication 😀 … We’re looking forward to tweaking our models and teasing apart the mechanisms with mutants!
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1/10 … Very excited to finally share the preprint of our work on DNA replication in mouse & human meiosis … Big learning curve, lots of fun, and some cool discoveries along the way! doi.org/10.1101/2020.09.23.3…
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9/10 ... This asynchrony also appears to affect recombination because we can predict the crossover potential of each chromosome using ONLY replication measures and chromosome size!
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10/10 … Finally, this whole adventure opens so many possibilities for future learning … the methods should be broadly applicable to studying other cell types and will allow us to dig deeper into what specific proteins link replication and recombination in mammals …
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With fanfare and plenty of pomp Trump promised he'd empty the swamp, But hadn't foreseen This could possibly mean His gang goes to prison (womp womp) @Limericking @twitmericks @potuslimericks #CohenPleaDeal #Manafort #trump
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kevbrick retweeted
#TaxScamBill #kleptocracy :a government or state in which those in power exploit national resources and steal; rule by a thief or thieves
Replying to @SenJohnMcCain
@SenJohnMcCain if a student of mine turned in a handwritten paper. It would receive a non passing grade for not following orders. If I submitted a hand written grant application to the federal government it would be rejected immediately. #TaxScamBill xitter.cf/Mikel_Jollett/status/9…
They just handed out the text of the Republican tax bill. It's is 479 pages long. They're voting on it TONIGHT. It's got HAND-WRITTEN pages. It creates a TRILLION dollars of debt. There were NO public hearings. @SenJohnMcCain says he's satisfied that this is "regular order."
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