@omicscience

Team Science. No Borders. Bring It On.

omicscience.org/
Joined March 2021
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  • Following51
  • Followers503
103Media
The A-team (plus me!) are in #chiangmai and excited to deliver a 1 week course on genetic epidemiology at the #CMU Center of multidisciplinary technology for advanced medicine. Thailand ❤️ @MargheBigossi @AC_Williamson @Ladyroho @QMUL_CEG @QMUL_WIPH
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omicscience@omicscience1 Mar 2024
#Fasting shaped human evolution and is practiced by billions of people for #health and #religious reasons, but what happens to our body beyond shifting energy sources? What happens to our bodies in *7 days* w/o any food? nature.com/articles/s42255-0…
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Eric Topol
@EricTopol1 Mar 2024
"An important landmark in investigations of fasting" How 7-day water-only fasting led to changes in >1,000 proteins, much of which were dissociated from the average 12.5 lb weight loss @NatMetabolism nature.com/articles/s42255-0… nature.com/articles/s42255-0…
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The study, by Claudia Langenberg at @QMUL PHURI institute, @omicscience and @pietznerm advances our understanding of what’s happening across the body after prolonged periods without food. It suggests a road map for future therapeutic interventions.
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Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases medrxiv.org/cgi/content/shor… #medRxiv
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New @QMULBartsTheLon and @berlinnovation research published today in @naturecomms shows genetic causes that may lead to better treatment for painful condition #Raynauds @uk_biobank @EastLondonGenes @pietznerm @omicscience @weareSRUK #RaynaudsAwarenessMonth qmul.ac.uk/media/news/2023/s…

Researchers find genetic cause of Raynaud’s phenomenon

qmul.ac.uk
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Proteomics outshines polygenic risk scores in predicting 218 common and rare diseases. Impressive C-statistics for some diseases for which we have few predictive tools in the clinic. @omicscience on a roll with Robert Scott @pietznerm and others medrxiv.org/content/10.1101/…

Proteomic prediction of common and rare diseases

Background For many diseases there are delays in diagnosis due to a lack of objective biomarkers for disease onset. Whether measuring thousands of proteins offers predictive information across a wide...

medrxiv.org
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#Multimorbidity is increasing globally, and addressing it requires a shift in the prevailing clinical, educational, & scientific thinking. New Review by Claudia Langenbeg & colleagues @QMUL @QMULBartsTheLon @LSHTM @ucl @omicscience nature.com/articles/s41591-0…

Biological and functional multimorbidity—from mechanisms to management

Nature Medicine - Multimorbidity is increasing globally, and addressing it requires a shift in the prevailing clinical, educational and scientific thinking. This Review discusses emerging...

nature.com
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The MRC Epidemiology Unit is committed to Open Science. A @ScienceMagazine paper using EPIC-Norfolk study data hosted on @omicscience is a good example of how our #OpenScience platforms can support innovative research in practice. Read our blog post▶️ mrc-epid.cam.ac.uk/blog/2023…
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Peter Robinson@pnrobins8 Jun 2023
I am deeply honored and delighted to be awarded a Humboldt Professorship for AI: humboldt-foundation.de/en/ex…

Peter N. Robinson - Humboldt Professorship for AI 2024

Peter N. Robinson is a pioneer in the computer-assisted genome and phenotype analysis of genetic diseases. His major work has been the development of the Human Phenotype Ontology, which is now a...

humboldt-foundation.de
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One really nice feature of QTLs for metabolites is the possibility to use biochemical knowledge to infer the likely causal gene for many of the associations..... let us know if you think we missed any obvious ones!
Eric Fauman (he/him)@Eric_Fauman10 Nov 2022
I have prepared a special set of 7 of my favorite novel gene associations that I will tweet out over the next 7 days. In the meantime, you can peruse my 791 causal gene annotations in sup table 7! Causal gene, a biologic rationale, and a pointer to the primary literature
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Using a #proteogenomic approach to link protein-encoding regions of DNA to diseases via the protein product, a research team led by scientists at the Unit & @berlinnovation have identified gene variants that increase the risk of severe #COVID19. mrc-epid.cam.ac.uk/blog/2022… 🧵(1/4)

Proteogenomic analysis explains why some people suffer more from COVID-19 than others - IMS...

A large number of people are still contracting COVID-19. Fortunately, most of them are experiencing only mild symptoms, largely thanks to the high vaccination rate. However, in some individuals the...

epi.ims.cam.ac.uk
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Replying to @RLorenzChua
Researchers find ELF5 gene a leading candidate behind severe COVID-19 news-medical.net/news/202201… #Gene #Genetics #Coronavirus #COVID #SARSCoV2 #ELF5 @ChariteBerlin @Cambridge_Uni @FU_Berlin @medrxivpreprint

Researchers find ELF5 gene a leading candidate behind severe COVID-19

Are there any risk factors that predispose patients to severe COVID-19 outcomes? A recent study published in the medRxiv* preprint server sheds light on this popular question. Using a combination of...

news-medical.net
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Analysis in >10,000 Fenland Study participants, published @NatureComms by @pietznerm @eleanorwheeler et al. shows integrating information from different #proteomics technologies can identify otherwise hidden links between proteins, human health & disease. mrc-epid.cam.ac.uk/blog/2021…
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BMFTR
@bmftr_bund20 Oct 2021
🧬🗺️ Proteine erklären, wie #Gene Krankheiten verursachen: Ein internationales Forschungsteam @berlinnovation konnte eine Landkarte 🗺️ verschiedenster Erkrankungen erstellen, die sich auf gemeinsame Ursachen zurückführen lassen. 👉 ow.ly/h1G650Gt30e #TranslationalMedicine
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Just out 👇👇👇
omicscience@omicscience14 Oct 2021
🚨paper alert🚨 We are thrilled to announce that our work on the #Genetics of ~5k #Proteins is out @ScienceMagazine >10k pQTLs creating a #proteogenomic map of the human phenome @MRC_Epid @berlinnovation @KastenmullerLab @GSK @IMS_MRL @UCL_IHI science.org/doi/10.1126/scie… 🧵👇
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A collaborative project that I am proud to be a part of has just been out in @ScienceMagazine! Read below for more information on the #genetics of ~5k #proteins and a #proteogenomic map of the human phenome👇👇 Many thanks to Claudia Langenberg,@pietznerm,@eleanorwheeler&others
omicscience@omicscience14 Oct 2021
🚨paper alert🚨 We are thrilled to announce that our work on the #Genetics of ~5k #Proteins is out @ScienceMagazine >10k pQTLs creating a #proteogenomic map of the human phenome @MRC_Epid @berlinnovation @KastenmullerLab @GSK @IMS_MRL @UCL_IHI science.org/doi/10.1126/scie… 🧵👇
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Excited to share our latest @ScienceMagazine led by Claudia Langenberg @pietznerm @eleanorwheeler. The proteogenomic resource (~5k proteins in >10k individuals) will be a fantastic one to help us clarify how genome variation affects human health & disease. We also integrate #GTEx
omicscience@omicscience14 Oct 2021
🚨paper alert🚨 We are thrilled to announce that our work on the #Genetics of ~5k #Proteins is out @ScienceMagazine >10k pQTLs creating a #proteogenomic map of the human phenome @MRC_Epid @berlinnovation @KastenmullerLab @GSK @IMS_MRL @UCL_IHI science.org/doi/10.1126/scie… 🧵👇
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The winner of the #EPCA2021 ‘Research award’ is…
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A new #metabolomics study in @NatureMedicine reports that shared metabolic alterations underlying multiple chronic diseases may help with the prevention and management of co-morbidity in patients. Read more: bit.ly/3sMVWp7. #research #biomarkers
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