@mdrwilson
 Edinburgh, UK
mdwilsonlab.com
Joined September 2012
  • Tweets74
  • Following171
  • Followers224
Wonderful collaboration, really excited to see the final version out.
Duncan Sproul@sproul_lab5 Feb 2024
The paper version of our DNMT3B study is now out in @emboreports 🥳: embopress.org/doi/full/10.10… You can read more on the previous thread but here is a summary of the main updates. This is one for Southern blot fans! 🧵1/9

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

EMBO Reports - The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to...

link.springer.com
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Marcus D Wilson retweeted
Duncan Sproul@sproul_lab5 Feb 2024
The paper version of our DNMT3B study is now out in @emboreports 🥳: embopress.org/doi/full/10.10… You can read more on the previous thread but here is a summary of the main updates. This is one for Southern blot fans! 🧵1/9

DNMT3B PWWP mutations cause hypermethylation of heterochromatin

EMBO Reports - The correct establishment of DNA methylation patterns is vital for mammalian development and is achieved by the de novo DNA methyltransferases DNMT3A and DNMT3B. DNMT3B localises to...

link.springer.com
Duncan Sproul@sproul_lab10 Jan 2023
New pre-print alert 🚨 @franci_tag shows that DNMT3B PWWP mutations cause hypermethylation of H3K9me3 heterochromatin that is facilitated by its N-terminus. You can read more here: biorxiv.org/content/10.1101/… But here is a quick summary 🧵 1/10
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Charlotte Crowe@CharlCrowe30 Nov 2023
Great talk by Hannah Wapenaar from @mdrwilson lab solving some beautiful structures and highlighting tips and tricks from data processing software packages for #cryoEM #Scottish_cryoEM23
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Fantastic to see the final version of this online now. Using a series of complex biochemistry we shone a light on how BRCA1-BARD1 is recruited to chromatin. academic.oup.com/nar/advance…

BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

Abstract. Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in

academic.oup.com
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Thanks also to reviewers for great insight @NAR_Open
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Finally this project was supported in our lab by @The_MRC @wellcometrust & @SBSatEd
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Ivan
@chaperones4life12 Oct 2023
BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes academic.oup.com/nar/article…

BRCA1–BARD1 combines multiple chromatin recognition modules to bridge nascent nucleosomes

Abstract. Chromatin association of the BRCA1–BARD1 heterodimer is critical to promote homologous recombination repair of DNA double-strand breaks (DSBs) in

academic.oup.com
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SCMI@SCMICryoEM21 Aug 2023
Our 10 week virtual course on the theory of cryo-EM returns again next month. Full details and registration: gla.ac.uk/research/az/cvr/fa… (NB. open to consortium member universities only)
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Charlotte Crowe@CharlCrowe4 Sep 2023
Join us for the first Scottish Symposium on Cryo-electron Microscopy !❄️🔬🏴󠁧󠁢󠁳󠁣󠁴󠁿eventbrite.co.uk/e/scottish-… @SCMICryoEM @UoDLifeSciences @UoDCeTPD @SULSAtweets co-organised with @Mark_A_Nakasone @TomOwenH @CharlCrowe
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Michael Ranes@MSRanes17 Aug 2023
Job Alert📢📢 We are recruiting postdocs in Protein Biochemistry bit.ly/45vrx1A & Cell Biology bit.ly/45ijcOX to join our lab @BiochemOxford. Join us to tackle the next big challenges in the Wnt signalling field in a fun, collaborative & supportive environment!
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orthweinlab@orthweinlab19 Aug 2023
We are very excited to share with you the results of great teamwork with @AmelieFT lab! In this study, two graduate students @lymphocytePC and @DessaptJcharacterized the critical role of FIRRM/C1orf112 in the disassembly of RAD51 during DNA repair. science.org/doi/full/10.1126…

FIRRM cooperates with FIGNL1 to promote RAD51 disassembly during DNA repair

FIRRM plays a role in the maintenance of genome stability.

science.org
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EMPIAR.org/EMPIAR-11454 contains raw data for the "Structure of the Nucleosome Core Particle from Trypanosoma brucei", published @NAR_Open (doi.org/10.1093/nar/gkad577) by the @mdrwilson lab @EdinburghUni. #EMPIAR #cryoEM #NeglectedTropicalDiseases
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Adele Marston@Marston_lab4 May 2023
We are delighted to establish our new Discovery Research Platform for Hidden Cell Biology @EdinburghUni and grateful to @wellcometrust for support. @SBSatEd @WTcell
Wellcome
@wellcometrust4 May 2023
Discovery research has near limitless potential, but researchers can be faced with barriers too substantial to overcome alone. To address this, we are directing £73 million into eight new Discovery Research Platforms. Learn more ⤵️ wellc.me/416bBjJ
Michael Dunn, Director of Discovery Research at Wellcome, says: "By providing substantial support focused on specific research challenges, we have the potential to revolutionise fields of research."

ALT Michael Dunn, Director of Discovery Research at Wellcome, says: "By providing substantial support focused on specific research challenges, we have the potential to revolutionise fields of research."

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#ProudPI @GauriDeak winning poster prize for her work on trypanosome chromatin #emblchromatin
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Raphaël Pantier@R_Pantier15 May 2023
Here is our latest work in which we explored the relationship between MeCP2, heterochromatin and DNA methylation using live-cell imaging. This is a collaboration with Tom Burdon @roslininstitute, Thomas Jenuwein @mpi_ie and Claude Libert @VIBLifeSciences. biorxiv.org/content/10.1101/…

MeCP2 binds to methylated DNA independently of phase separation and heterochromatin organisation

Correlative evidence has suggested that DNA methylation promotes the formation of transcriptionally silent heterochromatin. Accordingly, the methyl-CpG binding domain protein MeCP2 is often portrayed...

biorxiv.org
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Ivan
@chaperones4life19 Apr 2023
NucleosomeDB - a database of 3D nucleosome structures and their complexes with comparative analysis toolkit biorxiv.org/content/10.1101/…

NucleosomeDB - a database of 3D nucleosome structures and their complexes with comparative analysis...

Nucleosomes are basic building blocks of chromatin, comprising DNA wrapped around an octamer of eight histone proteins. They play key roles in DNA compaction, epigenetic mark up of the genome and...

biorxiv.org
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Thanks for the kind words, glad you enjoyed.
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Brilliant 🧵 highlighting the key take home messages we learnt from our characterisation of nucleosomes from the divergent eukaryote T.brucei by @GauriDeak
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