@CharlCrowe

Postdoctoral Fellow @Genentech / PhD & Postdoc @AlessioCiulli @UoDCeTPD 🏴󠁧󠁢󠁳󠁣󠁴󠁿🇬🇧/ MChem @univofstandrews / from Strasbourg 🇫🇷

 St Andrews, Scotland
Joined July 2019
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Mechanistic and structural insights into degrader-targeted protein ubiquitinability, now out in @ScienceAdvances! science.org/doi/10.1126/scia… Let's make more degraders that hit the bull's eye 🎯 @alessiociulli @UoDCeTPD
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Charlotte Crowe retweeted
Guillaume Laconde@Glaconde34Jul 16
Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC @alessiociulli @CharlCrowe 👏nature.com/articles/s41467-0…

Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed...

Nature Communications - Proteins lacking defined ligandable pockets are challenging drug targets. Here the authors combine molecular glue-stabilizer and PROTAC strategies to enable ubiquitination...

nature.com
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An excellent and timely review: Crowe & Ciulli (2026) Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders. Chem Rev ASAP #TPD #ChemBiol #MedChem #OpenAccess doi.org/10.1021/acs.chemrev.…

Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders

Abstract. Small-molecule degraders eliminate disease-driving proteins by hijacking the ubiquitin-proteasome system. To achieve cellular activity, protein d

pubs.acs.org
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Charlotte Crowe retweeted
Tasuku Ishida@TasukuIshida1May 15
TPD開発の際に考慮すべきことやアッセイ系の原理と利用場面などに関してまとめた総説がChemical Reviewsに公開されています。OAです。 余談ですが、First authorのCharlotte(@CharlCrowe)は、Dundeeではドラフトが隣でした。 pubs.acs.org/doi/10.1021/acs…

Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders

Abstract. Small-molecule degraders eliminate disease-driving proteins by hijacking the ubiquitin-proteasome system. To achieve cellular activity, protein d

pubs.acs.org
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Tuning linker rigidity and length determines whether a ternary complex orientation leads to: - Efficient substrate ubiquitination & degradation, - Partial or inefficient ubiquitination, - Or complete stabilization through a locked, non-productive geometry.
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We combined cryo-EM, chemical design & synthesis, ternary complex and ubiquitination biophysics & biochemistry, and cellular profiling to tease out the mechanisms at play.
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An absolute pleasure to work with all co-authors on this study: from @alessiociulli’s lab (the 🤝 House of VHL 🤝) @ales_salerno & Gajanan Sathe – and our wonderful collaboration Graham Marsh and Hannah Maple from @Tocris @biotechne.
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From degradation to stabilisation! Reprogramming the VHL-degrader CM11 into VHL-stabilisers through linker design, locking a non-ubiquitinable ternary complex. 🔗biorxiv.org/content/10.1101/…
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House of VHL meets house of 14-3-3 🤝 Presenting our study “Induced ubiquitination of the partially disordered Estrogen Receptor alpha protein via a 14-3-3-directed molecular glue-based PROTAC design” 🔗biorxiv.org/content/10.1101/…
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Huge well done to our co-first author Carlo Verhoef and all our fantastic co-investigators @Mark_A_Nakasone, Aitana @DeLaCuadraBaste, Tessa Harzing, Naomi Span, Gajanan Sathe, Kentaro Iso, @COttmann1433, Luc Brunsveld and - last but not least @AlessioCiulli & Peter Cossar
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Excited to see how this MGPROTAC concept evolves and what new disordered targets we can take on next!
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After the Krios I's 10-year birthday earlier this year (full story can be found here: lnkd.in/eCKF3vBF), it was awesome to visit the eBIC facilities at @DiamondLightSou and see that the epic party hat still lives on 🥳
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Awesome view over the river Tay yesterday afternoon, on the train heading down to @DiamondLightSou for the @ccp_em Icknield workshop -- the famous haar (fog) was in full force ⛅️
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Catch up on the latest #TPD literature, check out the August-September edition of the @UoDCeTPD Journal Club!
Centre for Targeted Protein Degradation@UoDCeTPD13 Oct 2025
The Aug-Sept Journal Club is ready!! Thanks to our amazing editors: @DeLaCuadraBaste, @_nicolamurdoch, Qinghzi, and Michael. If you are interested in the latest TPD literature, have a look! buff.ly/JQPQrXK #openaccess #TPD #journalclub @UoDLifeSciences
Scientists, smile while looking at something. With the text "CeTPD Journal Club, August - September 2025

ALT Scientists, smile while looking at something. With the text "CeTPD Journal Club, August - September 2025

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Fantastic experience attending the LITE Annual Meeting 2025 in San Francisco, as part of the @MichaelJFoxOrg initiative to accelerate therapeutic discovery in Parkinson’s disease An exciting few days of science with academic and industry partners from across the consortium!
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Our @UoDCeTPD PIs @AlessioCiulli, @farnaby84 and Peter Cossar represented the team presenting progress on our several ongoing projects with Aina, @alex_hallatt, @_Deenwood, Jack and Zher Yin
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Had an awesome time at the 3rd Scottish Symposium on Cryo-EM! Great to see the community growing, get updates on the exciting equipment🔬 across Scotland and catch up about projects! Many thanks to the Edinburgh team @mdrwilson lab for hosting us this year 😊
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Celebrated graduating last June with my favourite people! Grateful to have my family together to mark the occasion!
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Looking forward to presenting this Thursday along with @ales_salerno! @DanaFarber @biomiko
Mikołaj Słabicki@biomiko15 Apr 2025
Join us on April 17th for an exciting double seminar from the University of Dundee @UoDCeTPD: @CharlCrowe on "Mechanisms of degrader-targeted protein ubiquitinability" and @ales_salerno on "FerroTACs." Details: danafarbertargetedproteindeg…
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Looking forward to participating in the @DanaFarber Targeted Protein Degradation webinar series this Thursday! Registration is open: dfci.zoom.us/webinar/registe…
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