@maxzylam

PI - Neuropsychiatric Genomics Laboratory @ IMH; Deputy Scientific Director PRECISE-SG100K National Precision Medicine Initiative

 Singapore
researchgate.net/profile/Max_Lam2
Joined November 2016
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🧬 New preprint alert! Our latest manuscript on MedRxiv investigates the complex pleiotropic genetic landscape of schizophrenia, cognitive function and educational attainment uncovering 768 significant loci – 159 of which are novel. medrxiv.org/content/10.1101/… @ToddLencz

Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics

Given the increasingly large number of loci discovered by psychiatric GWAS, specification of the key biological pathways underlying these loci has become a priority for the field. We have previously...

medrxiv.org
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🔬 Our new results dissociate forebrain and hindbrain neurodevelopmental processes, and implicate translation initiation factors in schizophrenia pathophysiology for the first time.
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📚 Our findings contribute to a deeper understanding of schizophrenia biology and pave the way for more targeted therapies and interventions. Stay tuned for updates on our cognitive genomics research! #Schizophrenia #Pleiotropy #MedRxiv #NIMH
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Max Lam retweeted
ISPG@ISPGnet5 Feb 2024
We are looking forward to 2024 WCPG in Singapore (15th-19th Oct). In the words of our 2024 Program Chairs, "These are exciting times in psychiatric genetics." Want to learn more? Check out the 2024 invitation to attend: ispg.net/wcpg-2024-invitatio… #psychiatry #genetics
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Deconstructing the genetic architecture of treatment-resistant schizop... sciencedirect.com/science/ar… @maxzylam @KeaneLim
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We are recruiting! DM if you are interested in doing research for precision medicine! – at Singapore
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🤩 OUT TODAY @NatureGenet 📰 The Singapore National Precision Medicine Strategy 👩🏾‍🤝‍👨🏽 John C. Chambers, E. Shyong Tai, Patrick Tan and team 👇🏿🇸🇬🧬👇🏿 go.nature.com/3ZZb186
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Pleased to announce the launch of: polygenicembryo.org The website of the Polygenic Embryo ELSI Research (PEER) Group (1/5)

Home | Polygenic Embryo ELSI Research Group

The 'PEER' Group is a team of researchers based at Harvard Medical School, Baylor College of Medicine, Hofstra University, and The Hebrew University of Jerusalem. The PEER Group investigates the...

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Our latest preprint: a novel cross-ancestry fine-mapping method with much improved power and calibration. A collaboration with @kaiyuan1990 @RyanLongchamps @AFPopgen @getian107 @ChiayenChen @YenFengLin @bmneale @dalygene @PGCgenetics among others! medrxiv.org/content/10.1101/…

Fine-mapping across diverse ancestries drives the discovery of putative causal variants underlying...

Genome-wide association studies (GWAS) of human complex traits or diseases often implicate genetic loci that span hundreds or thousands of genetic variants, many of which have similar statistical...

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Glad to share this manuscript doi.org/10.1038/s41380-022-0… which is finally out in @molpsychiatry. Previous studies identified immune gene dysregulations in the brains of patients with several major brain disorders. (1/7)
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New manuscript @NatureComms! We leveraged data from 19 cognitive GWAS to disentangle biological mechanisms underlying psychopathology (17 psychiatric GWAS). Some updates from the previous tweetorial! (1/8)
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The results might provide insights into the potential of nootropic agents targeting specific biological mechanisms to alleviate functional disability within psychopathology. (8/8)
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A big thank you and shout out to @ToddLencz @ChiayenChen @getian107 @hailianghuang for their valuable insights and help on this effort!
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