@KeaneLim

Interested in psychiatric genetics & neuropsychology · Own views

 IMH, Singapore
Joined August 2019
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Our new paper out in @SchizBulletin found & replicated 4 distinct cognitive profiles in schizophrenia. Subtypes consists of a “less impaired” subtype, two “intermediate cognitive impairment” subtypes differentiated by executive function, & “globally impaired” subtype.
Schizophrenia International Research Society@SIRSGlobal25 Nov 2020
Managing heterogeneity of #schizophrenia using cognitive subtyping: A latent profile analysis using data from 762 patients reveals 4 distinct profiles that were stable across time and were associated with clinical outcomes. doi.org/10.1093/schbul/sbaa1… @SchizBulletin @KeaneLim
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This 4-profile cognitive solution showed stability across time. CFA revealed cognitive profiles are better explained by distinct profiles rather than a severity continuum.
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Thank you all participants & co-authors (Jason Smucny, Deanna Barch, @maxzylam, Richard Keefe, Jimmy Lee) for being a part of this work!
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Our new work out on @PLOSONE investigating the genetic liability of the Ultra-High Risk (UHR) psychosis state @maxzylam Hailiang Huang, Jianjun Liu, Jimmy Lee journals.plos.org/plosone/ar…

Genetic liability in individuals at ultra-high risk of psychosis: A comparison study of 9 psychia...

Individuals at ultra-high risk (UHR) of psychosis are characterised by the emergence of attenuated psychotic symptoms and deterioration in functioning. In view of the high non-psychotic comorbidity...

journals.plos.org
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Caveats: The lack of association between our Asian UHR cohort with other psychiatric traits may be due to differing ancestry & sample size of the training & target datasets. Further studies are warranted for replication.
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Lastly, thank you all participants & co-authors for being a part of this work!
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#LinkUpdate Making progress in psychiatric genetics: two new #Anxiety GWAS published 1) Million Veterans ajp.psychiatryonline.org/doi… 2) #ArmySTARRS onlinelibrary.wiley.com/doi/… Joins two previous studies 3) @uk_biobank nature.com/articles/s41380-0… 4) iPSYCH ajp.psychiatryonline.org/doi…

Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million...

Objective:Anxiety disorders are common and often disabling. The goal of this study was to examine the genetic architecture of anxiety disorders and anxiety symptoms, which are also frequently...

psychiatryonline.org
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"Unlike neurocognitive tasks that are less dependent on cultural specificities, social stimuli are often abstract or utilize words with meanings that are not fully equivalent across cultures" - Hajdúk et al in @SchizRes sciencedirect.com/science/ar…
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Our new @TheLancetPsych paper examines metabolic side effects of 18 antipsychotics in the treatment of schizophrenia: a network meta-analysis of 100 RCTs and over 25,000 patients. Here’s a tour of the paper, with some unexpected results… [thread] 1/n thelancet.com/journals/lanps…
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Excited to share our new work on the psychometrics of social cognitive measures in an Asian schizophrenia sample. Huge thanks to Sara-Ann Lee, Amy Pinkham, @maxzylam , Jimmy Lee for this! Thread follows (1/8) sciencedirect.com/science/ar…
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Our findings partially replicated SCOPE's where BLERT & ER40 showed best psychometrics. However, its premature to exclude tasks with poor psychometrics for further evaluation as cultural modifications/adaptations may be required (7/8)
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Finally, we would like to thank all our participants who participated in this study! (8/8)
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