@martripodi

Group Leader, MRC Laboratory of Molecular Biology - Views & opinions are my own. on BlueSky: TripodiLab

 Cambridge
tripodilab.com
Joined October 2011
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Another good week for neuroscience research. My favorite papers this week. [🧵3]:
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A new study from the Joesch Lab describes how the vLGN collicular circuit participates in stabilising visual information during action, with the vLGN acting as a corollary discharge hub so that images don’t blur when we move our eyes. nature.com/articles/s41593-0…

A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor...

Nature Neuroscience - Animals must distinguish between signals from sensory stimuli and action-generated signals. This paper shows that the ventral lateral geniculate nucleus acts as a corollary...

nature.com
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MARBLE (MAnifold Representation Basis LEarning), a new method from the @trekkinglemon Lab to obtain interpretable and decodable latent representations from neural dynamics. nature.com/articles/s41592-0…

MARBLE: interpretable representations of neural population dynamics using geometric deep learning

Nature Methods - MARBLE uses geometric deep learning to map dynamics such as neural activity into a latent representation, which can then be used to decode the neural activity or compare it across...

nature.com
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A very welcome addition to the NatSci syllabus!
Markus Meister@mameister420 Feb 2025
Here it is finally: Our mathematical methods book for life scientists! Aimed at advanced undergrads and beginning grad students, plus all those who want a deeper look at the math behind quantitative biology. 1/3
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1) THE PATHS OF DEVELOPMENT ARE DIFFERENT IN THE PALLIUM OF AMNIOTES! Mammals process sensory information in the neocortex (dorsal pallium) whereas sauropsids process it in the dorsal AND ventral parts of the pallium. These territories are different at molecular, not equivalents.
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This week’s highlights in neuroscience [🧵5] 1. A tour de force from the @BaierLab to map molecular phenotypes to function in the optic tectum. Takeaway message: molecular codes matter but only when combined with developmental trajectories and topography nature.com/articles/s41586-0…

Transcriptomic neuron types vary topographically in function and morphology

Nature - Transcriptomic profiling of neurons from the zebrafish optic tectum identified more than 60 cell types; functional imaging revealed that response tuning, morphology and connectivity of...

nature.com
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5. @PhyloBrain on the evolutionary origin of mammalian neocortex. The neocortex is truly a mammalian invention with no clear evolutionary homologs. Higher-order integrative circuits appear to have evolved independently in different vertebrate taxa science.org/doi/10.1126/scie…

Evolutionary convergence of sensory circuits in the pallium of amniotes

The amniote pallium contains sensory circuits that are structurally and functionally equivalent, yet their evolutionary relationship remains unresolved. We used birthdating analysis, single-cell RNA...

science.org
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Thank you and your team for the incredible work! I’m curious to know your thoughts on the Gecko findings. Could those findings still be compatible with a common ancestor?
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If you haven’t seen it yet, check out our paper on multimodal mismatch responses, which is now out in eLife. Thank you to the @eLife editorial team and reviewers for a pleasant and constructive revision process. elifesciences.org/articles/9…

Multimodal mismatch responses in mouse auditory cortex

Audiomotor mismatch responses in auditory cortex are amplified by concurrent visuomotor mismatches, highlighting non-hierarchical and multimodal processing of prediction errors.

elifesciences.org
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What an extraordinary achievement! Congratulations to everyone involved.
Greg Jefferis@gsxej2 Oct 2024
Big day for neuroscience & the end of the beginning for whole brain connectomics. Shout out to @sdorkenw and Philipp Schlegel, first authors of the connectome papers, @MurthyLab @SebastianSeung for establishing #flywire to make this possible and @dddavi for birthing this dataset.
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I am delighted to see this published. Many years in the making and only possible thanks to the unwavering determination of @AGonzalezRueda. Thanks to all lab members and collaborators involved!
Ana González Rueda@AGonzalezRueda3 Jul 2024
Our latest paper is out @Nature!! 🧵1/4 By exploiting the genetic identity of premotor neurons in the SC, Self-inactivating Rabies, in vivo ephys and computational modelling, we challenged the current view on sensorimotor alignment. nature.com/articles/s41586-0… @MRC_LMB @martripodi
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It has been an eventful year ... ! Excited that I joined the Faculty at @BirkbeckUoL where I look forward to establishing my own lab and continuing my work on OCD. 🧠 Check out our website vaghilab.org/ & get in touch if interested! 1/3

ABOUT | VaghiLab

vaghilab.org
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Two Postdoctoral opportunities in our group: 🧬 Molecular: Developing new methods to map and manipulate neural circuits. lnkd.in/e2NvABtu 🧠Neurophysiology: Investigating the relationship between motor and cognitive control. lnkd.in/eJn3_r4J Pls RT.

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Congratulations to @HassalLee and @ErnestoCiabatti for paving the way to a new field of #NetworkGenomics with their latest work on SiR2.0. A big thank you to everyone involved in supporting this journey. @MRC_LMB @ERC_Research
Hassal Lee@HassalLee4 Mar 2023
Linking connectomic and transcriptomic studies with novel SiR! #NetworkGenomics with @ErnestoCiabatti @martripodi @MRC_LMB & collaborators. Article @SpringerNature @Naturemethods: nature.com/articles/s41592-0… News&views: nature.com/articles/s41592-0… @CambridgeMBPhD @LMB_PhD #neuroscience
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Do you like onion rings, doughnuts and other topological delights? Then check out our new paper with @kao_calvin, @martripodi, and @GJEHennequin where we build Gaussian process latent variable models with non-Euclidean latent spaces! arxiv.org/abs/2006.07429 (1/7)
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Few months ago Matsuyama et al. released an early report on the issue of the genomic stability of Self Inactivating Rabies (SiR) from our Ciabatti et al 2017. This stimulated us to run new experiments to investigate the SiR stability and other points raised by Matsuyama et al.
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3. When starting from non-mutated SiR, revertant mutations never emerge during the course of in vivo experiments.
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For more details please see: biorxiv.org/content/10.1101/… It has been a fruitful investigation that hopefully expanded our understanding of how these promising tools can be used by the community

Genomic stability of Self-inactivating Rabies

Transsynaptic viral vectors provide means to gain genetic access to neurons based on synaptic connectivity and are essential tools for the dissection of neural circuit function. Among them, the...

biorxiv.org
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