Neural Circuits and Behaviour in Drosophila @MRC_LMB. PI @flyconnectome @CamZoology and @virtualflybrain. Tweets my own.
Cambridge, UK
Joined July 2010
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Building the FlyWire #connectome from the FAFB brain was a massive team effort. But neuroscientists need to find their favourite neurons in this huge dataset. We report an indexed parts list, systematically annotating all 127k neurons (Schlegel et al biorxiv.org/content/10.1101/…) 1/7
We are releasing a whole-brain connectome of the fruit fly, including ~130k annotated neurons and tens of millions of typed synapses!
Explore the connectome: codex.flywire.ai/
Reconstruction paper: biorxiv.org/content/10.1101/…
Annotation paper: biorxiv.org/content/10.1101/…
1/6
Personal and scientific post: Proud of Ana Lisa's work with her colleagues at Genomics England and beyond to help improve treatment as well as diagnosis of rare disease.
"I believe we are going through a transformational change, and the rare community is helping to achieve the impossible."
Read the blog from Ana Lisa Tavares, Clinical Lead for Rare Disease Research, linked below: ow.ly/AhAc50Yl03X
#RareDiseaseDay
ALT Headshot of Ana Lisa against a background of Genomics England brand colours.
And here's the official announcement from our colleagues at Janelia. We can already see downloads are humming and we have fielded and solved the first data access queries. Happy exploring! #drosophila #connectomics #malecns.
🪰 A team of researchers has unveiled the complete connectome of a male fruit fly central nervous system—a seamless map of all the neurons in the brain and nerve cord of a single male fruit fly and the millions of connections between them.
🔗 janelia.org/news/researchers…
Exciting news for #drosophila #connectomics and #neuroscience enthusiasts: the Drosophila male central nervous system connectome is now live and free to use and explore. Find out more at the landing page hosted by our Janelia FlyEM collaborators janelia.org/project-team/fly….
ALT A multicolour 3D rendering by Philip Hubbard (Janelia) of neurons in the male brain and nerve cord connectome.
This dataset provides two major advances. It is the first fully proofread and annotated brain and nerve cord connectome with 166,696 proofread neurons annotated with 11,691 cell types. It is also the first connectome of a male brain.
Greg Jefferis retweeted
📢We’re recruiting!
🌳Assistant Professor in Ecology, Evolution & Conservation
A permanent teaching-focused position in our vibrant, welcoming and intellectually stimulating academic community.
Deadline: 7 September.
Apply here: bit.ly/3HKtNeZ
Neuronal diversity is written in transcriptional codes 🧬. But what is the logic of these codes that define cell types and wiring patterns?
To find out we built a #scRNAseq developmental atlas of the Drosophila nerve cord and linked it to the #connectome 🪰🧠
Tweeprint! ⬇️1/8
ALT ALT text: A UMAP representation of a single cell RNAseq dataset from the Drosophila ventral nerve cord as well as images of the Drosophila nerve cord connectome and different stages of fly development.
After building a beautifully annotated single cell atlas, senior authors @SebaCachero and @_erika_dona found a hidden birth order code. @biorxivpreprint here: biorxiv.org/content/10.1101/…. Read on for more ⬇️2/8
Greg Jefferis retweeted
Wouldn't it be great if we could not only image large connectomic volumes, but also completely reconstruct them? And if a whole mouse brain project didn't cost billions?
With the PATHFINDER preprint (biorxiv.org/content/10.1101/…), we preview a future where it doesn't have to.
Greg Jefferis retweeted
🔍 Masters or PhD student in London? Want to make your research faster, smarter & more reproducible — even without coding experience?
Join our hands-on tech bootcamp 👇
🔗 noblackboxes.org/bootcamp
⏰ Deadline 10 May 2025
Follow @NoBlackBoxes
#PhDLife #ResearchTools
Greg Jefferis retweeted
Our lab website is up! We are hiring at all levels.
dolanlab-tcd.com/
Greg Jefferis retweeted
⏰Last days to apply to the #Interacting with #Neural #Circuits course!
⏳ Apply by March 19th
🔗 loom.ly/OMvqMcE
📍 Jun 8 - 27, Lisbon
#NeuralCircuits #Optogenetics #NeuroTech
Greg Jefferis retweeted
Our new paper on the circuit implementation of evidence integration in larval zebrafish is now on bioRxiv!
We are proud to present our new preprint “Correlative light and electron microscopy reveals the fine circuit structure underlying evidence accumulation in larval zebrafish”, just posted on bioRxiv (biorxiv.org/content/10.1101/…). (1/10)
Greg Jefferis retweeted
The London Underground Mosquito lives underground, feeds on mammal blood & breeds in confined spaces - has it evolved in 200 years, or does it have a longer history? Research on genomes @YukiHaba_ &al @flygirlNHM suggests older Middle East origins doi.org/10.1101/2025.01.26.6…
Greg Jefferis retweeted
Dear All, I believe that this thread will become one of my most important contributions to the fly field (I hope I will make other contributions)! Here, I introduce the Soy Milk Machine Fly Food Method, a.k.a., DeepCook!#Drosophila#NewPI
Greg Jefferis retweeted
We're looking for a postdoc with a strong interest in the structure, function and cell biology of glutamate receptors and excitatory synapses.
nature.com/naturecareers/job…
Greg Jefferis retweeted
The deadline for the @TReNDinAfrica workshop in Zambia has been extended!
Apply by January 31 for this intensive entry level course on the basics of computational neuroscience and machine learning.
🧠 More info: trendinafrica.org/trend-cami…
Greg Jefferis retweeted
📢 Join us! We are recruiting an Associate Professor / Professor of Developmental Plasticity and Robustness to join our innovative research community!
Find out more about the position and apply: jobs.cam.ac.uk/job/49343/
ALT Graphic showing cell walls and text reading 'Apply now! Associate Professor/Professor of Developmental Plasticity and Robustness. Apply by 26 January. Find out more about the School of Biological Sciences on our website: www.bio.cam.ac.uk'
Greg Jefferis retweeted
🎉Happy New Year! Start 2025 by investing in your future!🚀
Just 2 weeks left to apply for our Computational Neuroscience & Machine Learning course🧠🤖
Let’s make this year one for growth & discovery. RT to spread the word!🙌
🔗trendinafrica.org/trend-cami…
#Growth #Opportunity
Greg Jefferis retweeted
📣Quick reminder about this amazing job opportunity.
One week to go until the deadline! – at Histon, England
JOB ALERT
We seek an engaged and effective research leader to join us @CamZoology as Prince Philip Professor of Ecology and Evolutionary Biology.
Wonderful colleagues, exciting opportunities to shape @Cambridge_SBS future.
Deadline 6 Jan
More here: jobs.cam.ac.uk/job/48966/