@naturemethods

Nature Methods publishes cutting-edge methods, tools, analyses, resources, reviews, news and commentary, supporting life sciences research. Tweets by editors.

 New York
nature.com/nmeth/
Joined March 2011
  • Tweets5.8K
  • Following1.1K
  • Followers156K
1.9KMedia
A Perspective discusses opportunities and challenges of using solid-state nanopores in molecular biophysics. nature.com/articles/s41592-0…

Solid-state nanopore sensing: the next workhorse of biophysical characterization

Nature Methods - This Perspective discusses opportunities and challenges of using solid-state nanopores for broader biophysical characterization.

nature.com
5
1
31
4,464
A Perspective discusses how to improve the reporting of neuroscience results. nature.com/articles/s41592-0…

Go figure: transparency in neuroscience images preserves context and clarifies interpretation

Nature Methods - This Perspective highlights the need for transparent thresholding rather than only showing results beyond fixed P values, to avoid the loss of valuable information and to improve...

nature.com
1
15
3,740
A small, photoswitchable, genetically encodable protein operating in the near-IR window enables applications in photoacoustic tomography. nature.com/articles/s41592-0…
11
65
5,172
Tangermeme: software for comprehensive, flexible and efficient cis-regulatory pattern identification and analysis. nature.com/articles/s41592-0…

Tangermeme: a toolkit for understanding cis-regulatory logic using deep learning models

Nature Methods - The tangermeme software package is a comprehensive, flexible and efficient Swiss Army knife for deep learning-based cis-regulatory pattern identification and analysis.

nature.com
20
72
6,499
Bottlenecks in the study of TCR-antigen specificity: nature.com/articles/s41592-0…

Towards high-quality large-scale T cell receptor antigen specificity data: challenges and promises

Nature Methods - Antigen recognition by T cells through their highly diverse T cell receptors (TCRs) is central to adaptive immunity, and recent high‑throughput methods and databases have...

nature.com
21
1
80
8,454
Stewardship of organoids: nature.com/articles/s41592-0…
9
44
5,397
Detecting, monitoring and mitigating false positives in lncRNA screens. nature.com/articles/s41592-0…

Confounders of lncRNA screens: sources, consequences and possible solutions

Nature Methods - Re-analysis of published long non-coding RNA (lncRNA) screens has revealed unexpectedly high false-positive rates in some reports, indicating that high-throughput genetic...

nature.com
4
10
4,886
Introducing bioAFM-DB, a databank for atomic force microscopy data. nature.com/articles/s41592-0…

A FAIR road to a bioAFM databank

Nature Methods - In this Comment, we direct attention to initial efforts to establish a high-quality databank of atomic force microscopy (AFM) data: bioAFM-DB. We outline the state of this...

nature.com
4
10
4,918
In a new Points of View, our columnists describe the application of 'principles of proximity' to generate engaging scientific figures. nature.com/articles/s41592-0…

Engaging figures

Nature Methods - Some visualizations resonate while others are forgotten. Why that is can be understood with the principles of creating ‘proximity’.

nature.com
1
20
4,682
In this month's Editorial, we provide some tips for writing well-structured and professional rebuttal letters for editors and peer reviewers to evaluate. nature.com/articles/s41592-0…

How to write a rebuttal letter

Nature Methods - The rebuttal letter is a vitally important document when revising a manuscript for a journal. Here we discuss how to communicate about your manuscript revisions in the best...

nature.com
10
28
5,051
Our October issue is live! 🎉 nature.com/nmeth/volumes/23/… On the cover, polygenic risk score prediction in diverse populations is made possible with a new computational tool, SPLENDID. Paper: nature.com/articles/s41592-0…
15
40
5,909
VIMA: a deep learning-based method to identify differentially enriched features in spatial datasets. nature.com/articles/s41592-0…
3
17
86
6,445
Read the associated Research Briefing, here: nature.com/articles/s41592-0…

Flexible discovery of disease-associated tissue structures

Nature Methods - Identification of disease-associated patterns in spatial molecular data is challenging. We introduce variational inference-based microniche analysis (VIMA), a deep learning-based...

nature.com
1
888
CCI-seq leverages combinatorial cell clump indexing and single-cell sequencing to capture large-scale cell-cell interaction networks. nature.com/articles/s41592-0…
12
1
44
5,563
Transferable retention time prediction across liquid chromatographic conditions and compound classes. nature.com/articles/s41592-0…

Times are changing but order matters: transferable prediction of small-molecule liquid chromatogr...

Nature Methods - A method for transferable retention time prediction across chromatographic conditions and compound classes is presented. The approach makes use of a two-step strategy that first...

nature.com
3
8
5,005
CytoVI: a deep generative model for statistically rigorous analysis of antibody-based single cell data. nature.com/articles/s41592-0…

CytoVI: deep generative modeling of antibody-based single cell data

Nature Methods - CytoVI is a deep generative model for statistically rigorous analysis of antibody-based single-cell data.

nature.com
1
5
19
5,164
Check out the @NaturePortfolio Collection of articles related to this year's Nobel Prize in Physiology or Medicine, here: nature.com/collections/addjh…

Nobel Prize in Physiology or Medicine 2026

The 2026 Nobel Prize in Physiology or Medicine has been awarded jointly to Karl Deisseroth, Peter Hegemann and Georg Nagel “for discoveries leading to ...

nature.com
1
5
3,656
Back in 2010 when we selected optogenetics as our Method of the Year, we had already observed the transformative impact that it was making on basic research in neuroscience. nature.com/nmeth/volumes/8/i… nature.com/articles/nmeth.f.… It's exciting to see how far the technology has come!

Nature Methods - Volume 8 Issue 1, January 2011

Optogenetics, our pick for Method of the Year 2010, is rapidly becoming a vital tool for neurobiologists, who are applying it to study both basic biology and...

nature.com
The Nobel Prize
@NobelPrizeOct 5
BREAKING NEWS The 2026 #NobelPrize in Physiology or Medicine has been awarded to Karl Deisseroth, Peter Hegemann and Georg Nagel “for their discoveries concerning light-gated ion channels and optogenetics.”
1
2
18
4,820
Spatial Hi-C allows the study of chromatin in a spatially resolved manner, as applied to adult and developing mouse brains. nature.com/articles/s41592-0…
3
21
92
8,155
Graphene reservoirs formed over perforated support films precisely control ice thickness during cryo-EM sample preparation. nature.com/articles/s41592-0…
1
5
1
17
5,398
Load more