New Investigator building a team focused on imaging mass cytometry, digital pathology, and systems biology #LTRI
Toronto
Joined September 2011
- Tweets259
- Following1K
- Followers758
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Hartland Jackson retweeted
The Desmoplastic and Neural Microenvironment of Pancreatic Cancer: Andreas Trumpp, Nina Steele, Min Li, Noor Shakfa, and Joshua H. Choe addressed this topic in a plenary session at the AACR Conference on Pancreatic Cancer.
#AACRpan26 @NinaSteele17 @NoorShakfa
Hartland Jackson retweeted
Elana Fertig, Hartland Jackson, Linghua Wang, Deniz G. Olgun, and Sungsik Kim discussed "Spatial Biology and Actionable Tumor Ecosystems: Beyond the Pretty Picture" to close out the AACR Conference on Pancreatic Cancer.
#AACRpan26 @hartjackson @IamLinghua
Hartland Jackson retweeted
🚨We're hiring!!🚨
The Biology Department @mcgillu is looking for a Quantitative Cell Biologist to join our diverse and interdisciplinary community.
Please share this ad broadly, and reach out if you have any questions.
mcgill.wd3.myworkdayjobs.com…
Hartland Jackson retweeted
IDH-mutant gliomas often progress slowly, but inevitably recur and progress. Are there spatial organizing principles at the level of cell states that repeat across tumours during stages of tumour progression?
cell.com/cancer-cell/fulltex…
Out this week in @Cancer_Cell, our work with @RouvenHoefflin, @TiroshLab, @MarioSuva, @GaliliNoam, and Christopher Mount quantitatively maps two independent axes of tumour organization, revealing how they emerge at different stages of progression and in distinct tissue contexts. We hope that understanding these recurring spatial patterns and associations will reveal new opportunities to halt tumour progression.
Hartland Jackson retweeted
We found a surprisingly large technical artifact hiding in a widely-used scRNA-seq technology.
In all Flex v1 datasets we’ve analyzed, we see hundreds of DE genes between probe set barcodes.
More on why this matters and what to do about it below:
biorxiv.org/content/10.64898…
(1/n)
Hartland Jackson retweeted
My PhD student Chi-Jane is graduating soon and looking for her next position. She is an expert in CyTOF and IMC analysis, especially :) she can help you to derive predictive immune signatures from your data 💻🧫chencookie.github.io/index.h…
Hartland Jackson retweeted
Must read preprint by @LabNotta pairing tumor & plasma whole genome sequencing (WGS) interrogating dynamics of ctDNA shedding in localized & metastatic #PancreaticCancer.
biorxiv.org/content/10.1101/…
Why is localized PDAC a “low shedder” & anticipating metastatic recurrence with WGS
Hartland Jackson retweeted
This elegant paper from Alex Raven + @owen_sansom at the @CRUKScotland shows that zonation in the liver is an important determinant of cancer development. I'm looking forward to seeing more research exploring how cell location influences tumorigenesis. nature.com/articles/s41586-0…
Hartland Jackson retweeted
Excited to share our new work on self-organized zonation in the intestine!
Enterocytes have location-dependent functions along the crypt-villus axis. How do cells "know" their position? Three possibilities: external signals, internal programs, or local cell communication. 1/6
Hartland Jackson retweeted
Hydroxychloroquine reduces metastatic tumor burden in #PancreaticCancer through myeloperoxidase (MPO) inhibition
journal-inflammation.biomedc…
This preclinical study shows HCQ binds to & inhibits the enzyme MPO which diminishes neutrophil extracellular traps or NET formation.
Hartland Jackson retweeted
Nothing but sincere gratitude for the joint AACR-CIHR Scholar-in-Training award at this year’s annual conference! Feeling inspired and excited for our work now more than ever 🔬👩🏻🔬 @CIHR_IRSC @AACR #AACR25
We are excited to bring 10 Canadian researchers to #AACR25 as part of the inaugural @AACR-CIHR Scholars-in-Training Awards collaboration. Last night, they joined other #AACRScholars in being recognized for their hard work and commitment to research. #CancerResearchSavesLives®
Hartland Jackson retweeted
When do pathology images and spatial transcriptomics tell us different things about tumour biology?
Our work on disentangled representation learning for paired pathology and spatial expression data will be presented as a spotlight at LMRL on April 28th at #ICLR2025
Hartland Jackson retweeted
Super excited to finally see this published! Our new method to use combinatorial staining and deep learning to push the multiplexing boundaries of spatial proteomics!
High-dimensional imaging using combinatorial channel multiplexing and deep learning go.nature.com/4hGPfO0
Hartland Jackson retweeted
Which are the highest cited original research publications in #PancreaticCancer over the past five years (from 2020 to 2024 end)?
All metrics obtained from Google Scholar (caveat: GS tends to OVERESTIMATE citations but the trends are consistent overall).
🧵 Below:
Hartland Jackson retweeted
#qTAG: Laurence Pelletier @laurpelletier and coworkers present an adaptable set of optimized #CRISPR repair cassettes for streamlined endogenous tagging, enabling diverse applications in functional protein studies within their native regulatory context
embopress.org/doi/full/10.10…
Hartland Jackson retweeted
Excited about spatial biology and Mass Spectrometry Imaging? Then explore and share the MALDI MSI workflow in Philippas preprint:
biorxiv.org/content/10.1101/…
@CRC_TRR332, @MS_Imaging, @asmsnews,
#myeloidCells, #msimaging, @IMSSNews
Hartland Jackson retweeted
Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !
Read here👉: doi.org/10.1038/s41587-024-0…
🔬 Highlights:
- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.
- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.
- Supports the structural modelling of protein complexes and the design of compounds targeting them
Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab
@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery
Hartland Jackson retweeted
When can multicellular niches be learned directly from single-cell atlases? 🗺️
We explore this in our latest preprint, including a novel discovery-validation setup, a probabilistic model for inferring niches, and find links between KRAS variants and niches in pancreatic cancer!
