@Zhu_Lab

Physician-scientist at @CRI_UTSW with a focus on #LiverCancer and organ regeneration.

 Dallas, TX
cri.utsw.edu/hao-zhu-laboratory-hao-zhu-md/
Joined March 2016
  • Tweets3.4K
  • Following652
  • Followers2.9K
81Media
Somatic mutations accumulate in “normal” non-cancerous tissues (blood, skin, liver). But why are mutant clones selected? Do they merely proliferate more, selfishly? Or can clones adapt to disease? Could they protect tissues? We shed light on this: authors.elsevier.com/a/1gua9… 1/10
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Congratulations to Amit Singal, M.D., on his election as President-Elect of the International Liver Cancer Association! Dr. Singal will serve as President-Elect in 2027 and ILCA President from 2028–2029, helping advance liver cancer prevention and treatment. @docamitgs @ILCAnews
Professional headshot of Amit Singal, M.D.

ALT Professional headshot of Amit Singal, M.D.

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SCI member @michelle_monje and team found that levetiracetam, an anti-seizure drug, disrupts GABAergic neuron-to-glioma synapses in #DMG #DIPG, slowing tumor growth and extending survival in both mouse models and retrospective patient data. brnw.ch/21x61gb
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Omer Yilmaz
@ohyilmaz
Sep 25
What gives some colorectal cancer cells the ability to metastasize? In our new paper, we find that tumor-intrinsic ceramide synthesis is a metabolic switch for metastatic initiation. 🧵 Free access: science.org/eprint/UAMCP9BAE…

Ceramide synthesis mediates colorectal cancer metastasis through a YAP-driven regenerative program

Mechanisms by which primary tumor cells acquire metastatic capability through metabolic and signaling adaptations are currently poorly understood. We demonstrate that tumor-intrinsic ceramide...

science.org
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You don't want to miss the first virtual event for the Summer Liver Academy Meeting (SLAM) Community! Join us on October 15 for a fantastic talk from Dr. Zhenghui Jiang bit.ly/3V6iIet #SLAM #LiverResearch #MASLD #ALD #Hepatology @harvardmed
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New from Heidelberg University 🚨 In healthy liver, CYP2E1 expression is predominantly localized to zone 3 hepatocytes. In chronic alcohol-related liver disease, CYP2E1 expression reflects pericentral hepatocyte integrity rather than ethanol responsiveness, emphasizing the need for cell-type validation in liver disease studies. Read the study: bit.ly/46D90D7 #Hepatology #LiverDisease #Epigenetics
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Daniel Heller@Dan_A_Heller
Sep 24
So excited to be part of this incredible work out today in @ScienceMagazine on how P-selectin-targeted anti-senescence nanotherapy can fight fibrotic conditions and cancers. Congrats to @LoweLabMSKCC and @hellerlab members and others @MSKCancerCenter!! science.org/doi/10.1126/scie…

Senescence-directed nanotherapy ameliorates fibrosis and overcomes immune exclusion in cancer

Fibrotic remodeling of tissues and tumors establishes immunosuppressive microenvironments that drive organ dysfunction and, in cancer, limit response to immunotherapy. Senescent-like cells are...

science.org
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Peter Ly@PeterLyLab
Aug 19
We are recruiting new faculty at all levels who seek to solve fundamental problems in biology and disease. @CRI_UTSW is an exceptional and highly collaborative environment to build a research program and pursue ambitious science. Join us!
Children’s Research Institute at UT Southwestern@CRI_UTSW
Aug 19
Come be part of our #relentlessdiscovery and discover the treatments of tomorrow. Faculty recruitment through Oct. 15 👉 cri.utsw.edu/careers
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Hao Zhu Lab retweeted
Eric Topol
@EricTopol
Sep 21
Timely, @Thelancet on GRAIL today! "To date, there is no evidence that any multicancer detection testing prevents cancer, consistently detects it at an earlier stage, or reduces cancer-associated mortality. Meanwhile, false-positive rates have been predictably high. The costs associated with evaluating false-positive results are very real, as are the psychological burdens borne by patients who are incorrectly told they have cancer—or incorrectly reassured that they do not." thelancet.com/journals/lance…

Multicancer detection tests: holy grail or cautionary tale?

A single blood test that can identify most cancers remains the aspirational goal of cancer screening. The US biotechnology company Grail has been closest to developing a viable multicancer detection...

thelancet.com
Eric Topol
@EricTopol
Sep 21
In its pivotal clinical trial, the GRAIL test to detect early cancer failed its primary endpoint. It detected only 3 early cases per 1,000 people assessed. There were more false negative results (N=196) than true positives (N=133). Reviewed here erictopol.substack.com/p/the… But you wouldn't know any of that if you read today's WSJ editorial! gift link wsj.com/opinion/a-grail-canc…
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The New York Times
@nytimes
Sep 20
Breaking News: Federal officials are drafting an executive order that would help cement President Trump’s ability to control billions of dollars in scientific grants funded by the National Institutes of Health. nyti.ms/4yhi6RS

White House Moves to Take Control of N.I.H. Grants

Federal officials are drafting an executive order that would place grants under review by an outside panel, the latest effort to redirect billions of dollars in research spending.

nytimes.com
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at ucsf
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Partnerships extend the reach of our #SomaticGenomics platform to explore complex biology across therapeutic areas. Hear from our CEO, Rahul Kakkar, MD, on how partnerships can drive the discovery of potentially breakthrough novel medicines. ​ Learn more: quotient-tx.com/partners
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Hsieh Lab@HsiehLab
Sep 16
Ever wonder how heterogeneity defines bladder cancer subtypes? Ha and Hsieh Lab postdoctoral fellows @pushpa_itagi and Samantha Schuster @fredhutch did, leading to a deep study of bladder cancer clonality, evolution, and heterogeneity published @Nature nature.com/articles/s41586-0…

Evolution and heterogeneity of lethal metastatic bladder cancer subtypes

Nature - A rapid autopsy programme provides valuable resources to enable detailed molecular and genetic analyses of the temporal evolution of aggressive histological subtypes and therapy resistance...

nature.com
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Kivanc Birsoy@KivancBirsoy
Sep 15
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…

Cysteine excess triggers a mitochondrial iron-dependent cell death

Nature Metabolism - Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a...

nature.com
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Dr. Len Zon@leonard_zon
Sep 12
Every so often, a major event happens in your life to validate years of work. SRRK’s ISEMBYLD was FDA approved. Having participated in its development from basic science to approval, as a physician-scientist, this is one of my best days. Happy for ISEMBYLD to help SMA patients.
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Eric Topol
@EricTopol
Sep 10
Prior to cancer immunotherapy, vaccination of any kind, not only vs Covid, is associated with a small and transient (~6 months) benefit of improved survival nature.com/articles/s41591-0…
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1/ T cell immunotherapies are thought to require tumor-specific T cells. Very excited to share our work showing how T cells can eliminate tumors without tumor specificity via paracrine signaling. 🧵 nature.com/articles/s41590-0…

Intratumoral T cell activation kills tumors regardless of T cell specificity

Nature Immunology - Here the authors show that T cell activation within tumors triggers tumor clearance that is independent of tumor antigen recognition and occurs via a paracrine mechanism...

nature.com
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Anirban Maitra@Aiims1742
Sep 10
Yesterday was a glorious day of science @nyugrossman @nyulangone with two fantastic papers 1st by @giladevrony on impact of caloric restriction on mutation rates: cell.com/cell/fulltext/S0092… 2nd by @MarcusDGon @eze_dantas on refined starches & immune markers cell.com/cell-press-blue/ful…
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How did we come to understand cancer in the light of evolutionary theory? Nothing makes sense if not with population genetics! In our latest @NatureRevCancer review we unpack how population genetics theory applied to somatic cells allows us to measure and predict cancer evolution from molecular data. Computational modelling in oncology has gone a long way but we need to go much further. The frontier is combining evolutionary theory with machine learning. Link below👇
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Check out this absolutely beautiful paper by Mathieu Deygas together with Pablo Vargas and Matthieu Piel. Stunning images and findings!
Science Magazine
@ScienceMagazine
Sep 8
Neutrophils remodel their actin cytoskeleton rapidly as they navigate narrow capillaries of varying sizes, enabling them to squeeze through without causing blockages. Learn more in @SciImmunology: scim.ag/4ibeax0
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Hao Zhu Lab retweeted
Gilad Evrony@giladevrony
Sep 9
Very excited to share our new paper, published in Cell! We found that caloric restriction (CR) in mice reduces somatic mutation burdens across the genome, and that this effect has some surprising features. 🧵👇 1/8
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