@Picotti_Lab
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Mass spectrometry-based #proteomics lab at @IMSB_ETH studying protein conformational changes & their effect on cell physiology. Tweets are from lab members
Zürich, Switzerland
Joined October 2019
- Tweets662
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Picotti Lab retweeted
Thank you European Proteomics Association for the JPA Proteome Pioneer Award in recognition for our group's work in this field. The award promotes "the principles of sharing and integrating resources for the development of excellent research" which is something we do strive for.
Here are the 2023 @EuPAProteomics Awardees! They will personally receive their prizes on Oct 22 at #HUPOEuPA2024. Congratulations to
@Sigridvrhlst, Laurent Gatto, @maurinefucito, @pedrobeltrao,
@DemichevLab, @akadfmfm !🥳
Our paper describing a new method (FLiP-MS) for the global profiling of protein complex dynamics is out @NatureBiotech !
Read here👉: doi.org/10.1038/s41587-024-0…
🔬 Highlights:
- Uses an experimental library of peptide markers integrated with a structural proteomics workflow.
- Probes the assembly state of hundreds of protein complexes simultaneously across conditions directly from whole cell extracts, informing on binding interface occupancy.
- Supports the structural modelling of protein complexes and the design of compounds targeting them
Congratulations to shared first authors @CathyMarulli and Christian Dörig and thanks to our collaborators @LabBarral and @TorstenSchwede lab
@ETH_en #Proteomics #PPIs #SystemsBiology #LiPMS #teammspec #DrugDiscovery
We are proud to announce that Ruedi Aebersold, founder of our institute and beloved colleague, will be awarded the Dr H.P. Heineken Prize for Biochemistry & Biophysics 2024. He receives it together with @labs_mann for their groundbreaking contributions to proteomics @ETH_en
Our paper describing a method to screen for conformation-specific protein-protein interactions is out @MolSystBiol.
Read it here: doi.org/10.1038/s44320-024-0…
The approach can also be used to map interaction sites.
@IMSB_ETH @ETH @ETH_en
#proteomics #massspectrometry #interactomes
We found novel candidate interactors for the monomeric and amyloid fibrillar forms of #AlphaSynuclein and for different conformational states of Rab GTPases.
A great collaboration with the @pedrobeltrao, @KorkhovLab Roland Riek and Sean Munro groups.
Congratulations, Albert. An exciting research area you are pioneering. We look forward to exciting discoveries ahead.
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High resolution protein complex analysis beyond AP-MS by the Gstaiger group: nature.com/articles/s41592-0….
Nice collaborative adventure at @IMSB_ETH from the @MGstaigerlab members @FabianFrommelt , @anfossati , @federico_uliana and from @bwollsch lab members
Picotti Lab retweeted
Exciting development for 🇨🇭 research!
Following a three-year hiatus, scientists from Switzerland can now participate in the 2024 ERC Advanced Grants.
The ETH Board wishes that this solution can be extended to all 2025 calls in summer 2024.
#HorizonEurope
Delighted that 🇨🇭 entities can now apply to @ERC_Research 2024 calls as we enter official negotiations for Swiss association to #HorizonEU & #EURATOM Research & Training programme!
More info 👉europa.eu/!qTwrgK
Picotti Lab retweeted
Publication by the Allain & Leitner Labs (@IMSB_ETH, @ETH_en) with 1st authors Tebbe de Vries & Mihajlo Novakovic (@tflut1,@Mehighlow993) "Specific #protein-#RNA interactions are mostly preserved in biomolecular #condensates" @ScienceAdvances
bit.ly/4cfo0sb
#MS #LLPS
Picotti Lab retweeted
N&V by @seth_margolis on the study by @Picotti_Lab & @MichalSharon3 developing an advanced #proteomics method (PiP-MS) to comprehensively explore 20S #proteasome substrates in the human proteome ➡️ embopress.org/doi/full/10.10…
Our warmest congratulations to Franziska Elsaesser on the successful defense of her PhD.
Excellent job, Franzi!
Great talk by Tetiana Serdiuk at the AD/PD conference on biochemical differences between amyloid strains linked to different alpha-synucleinopathies. @adpdnet
We also learned about the thermal behavior of intrinsically disordered proteins. Many predicted disordered regions may fold in situ!
This study is the result of an excellent collaboration with the @wolfgangkhuber lab, @ArosioLab_ETH, @EWB_Lab, @BrittaVelten lab and @HeatherDMaynard lab!
@IMSB_ETH @ETH @ETH_en @embl #proteomics #massspectrometry #proteinstability #osmolytes
Our paper on the mechanisms of protein thermal stabilization by osmolytes is out @nchembio. We found that osmolytes thermally stabilize many proteins in situ using various mechanisms (but there's a dominant one – read the paper to find out).
Read it here: nature.com/articles/s41589-0…
Picotti Lab retweeted
The paper by @KorkhovLab, together with @Picotti_Lab, Alexander Leitner and @federico_uliana, now out in @emboreports, describes the cryo-EM- and structural proteomics-based analysis of adenylyl cyclase AC8 and its macromolecular complexes. More: biol.ethz.ch/en/news-and-eve…
Picotti Lab retweeted
So happy to see our work published at @CellCellPress !
We added the quaternary structure dimension to proteome-wide, #AlphaFold2 predictions:
The published paper: sciencedirect.com/science/ar…
The original 🧵 (Two more experimental structures since!)
nitter.cf/ElevyLab/status/166819…
⚛️Protein structures are key to elucidating molecular details of cellular processes. #AlphaFold2 & others unveiled millions of tertiary structures, but these proteins' quaternary structures remain mostly a mystery. Here's how to bridge the gap. Thread👇 biorxiv.org/content/10.1101/…
Picotti Lab retweeted
A systematic investigation of 20S #proteasome substrates reveals 100s of substrates & differential functionality of naïve and oxidized 20S proteasome complexes ➡️ embopress.org/doi/full/10.10…
@Picotti_Lab @IMSB_ETH @MichalSharon3 @WeizmannScience #proteomics #massspectrometry
Our paper with @MichalSharon3 is now live @MolSystBiol. We identified hundreds of substrates of the 20S proteasome, enriched in RNA- and DNA-binding proteins with IDRs. A variety of substrates showed site-specific cleavage, suggesting functional products.
embopress.org/doi/full/10.10…
