@csadegh
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Pediatric neurosurgeon @UCDneurosurgery
Sacramento, CA
Joined June 2009
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Exciting progress toward gene therapy in hydrocephalus. And for targeting the choroid plexus as a platform for neurological intervention.
New preprint on #bioRxiv 🧵 We first showed that ablating the choroid plexus cuts CSF production in ROSA26-iDTR mice. Now we’ve engineered an AAV5-DTR vector that does this robustly in both neonatal and adult animals!
Cameron Sadegh retweeted
Led by @ScienceYael and out today in @NatureNeuro: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread rdcu.be/eoaSY
Cameron Sadegh retweeted
We are delighted to share our year of exceptional growth with you in our 2024 Year in Review. Learn about our BCI research that restored speech for a man with ALS, exciting new treatment paradigms, our growing Global Neurosurgery Program and more: heyzine.com/flip-book/UCDavi…
Cameron Sadegh retweeted
Brilliant work from Dr. Cameron Sadegh @csadegh and team. We are so fortunate that Dr. Sadegh has joined us here at @UCDavisHealth and gave an outstanding talk this morning on the intricacies of #choroidplexus. – at Sacramento, CA
Intraventricular hemorrhage (IVH) is the leading cause of pediatric hydrocephalus in North America and a devastating complication of preterm birth. Work led by @csadegh & @Huixin_BJ in @NeuroCellPress suggests choroid plexus gene therapy may help. 1/6
authors.elsevier.com/sd/arti…
Cameron Sadegh retweeted
We are so very fortunate to have an exciting lecture from Dr. Cameron Sadegh @csadegh from UC Davis Neurosurgery this morning in our #Stemcell & #genetherapy seminar series. He gave an outstanding talk on the intricacies of #choroidplexus and how to potentially treat #hydrocephalus through AAV gene therapy. 🧬 – at Sacramento, CA
Cameron Sadegh retweeted
@DrDavidBrandman and I, together with @csadegh, are looking to hire a lab manager (~2/3 effort for the Neuroprosthetics Lab). If you know someone who's looking for a long-term career supporting innovative neurological health research, please send them 👇
careerspub.universityofcalif…
Cameron Sadegh retweeted
Celebrating success as we wrap up the 2023 HA & RSRI Research Workshop in Dallas, TX today. This year's focus on developing non-invasive #hydrocephalus therapies brought together brilliant minds and innovative ideas. Together, we're forging new paths in hydrocephalus research.
Cameron Sadegh retweeted
Great work by lead by @csadegh @Huixin_BJ and @LehtinenLab ! NKCC1 as gene therapy in a mouse model of pediatric post-hemorrhagic hydrocephalus.
Online now: Choroid plexus-targeted NKCC1 overexpression to treat post-hemorrhagic hydrocephalus
Check out this study led by @LehtinenLab @HMS_Neuro @BostonChildrens @NeuroCellPress #ASGCT23 hubs.li/Q01Q0MV90
Cameron Sadegh retweeted
Intraventricular hemorrhage (IVH) is the leading cause of pediatric hydrocephalus in North America and a devastating complication of preterm birth. Work led by @csadegh & @Huixin_BJ in @NeuroCellPress suggests choroid plexus gene therapy may help. 1/6
authors.elsevier.com/sd/arti…
Cameron Sadegh retweeted
Happy postdoc appreciation week to the unparalleled Lehtinen Lab postdocs!⭐️You all do so much to cultivate lab wisdom, conduct amazing science, and facilitate countless collaborations.
meme credit: science Twitter
Cameron Sadegh retweeted
Random: One time I was operating with the Chair of Neurosurgery at Boston Children’s - Dr Mark Proctor! I was slumped over while removing the skull. He told me, “Stand up, Myron. Be proud of your work!” Now I hear his voice every time my posture fails. Great mentorship! #2%
Cameron Sadegh retweeted
ChP-CSF targeted antioxidant therapy protects the brain from toxicity of cancer chemotherapy.🧠doi.org/10.1016/j.neuron.202…
Excited to have this collaborative investigation with Boryana from @kanareklab @KanarekNaama out in @Neurocellpress, led in our lab by @JangAhram. [1/3]
Cameron Sadegh retweeted
Amazing talks this morning by @AtharNMalik , @CKLeemd , @CSadegh describing their residency journeys and their appreciation for the support of their families, friends, and colleagues. So fortunate to have worked with these three tremendous individuals who are graduating today!
Cameron Sadegh retweeted
Which Boston #neurosurgery program deserves to sit in the iron throne? From Harvey Cushing on, learn about the history and competition between these storied programs. ow.ly/llxM50GhRLx
Cameron Sadegh retweeted
Nathaniel Sisterson @ndsisterson and Cameron Sadegh @csadegh review shunts this morning @MGHNeurosurg #neurosurgery #shunt #hydrocephalus
Cameron Sadegh retweeted
Cameron Sadegh @csadegh brings a new perspective to #hydrocephalus in an outstanding grand rounds this morning & illustrates the power of collaboration @MGHNeurosurg @MGHNeuroSci
Cameron Sadegh retweeted
Hear from residents and attendings in the @MGHNSResidency Program about the collaborative culture, unparalleled clinical training, access to complex cases and expansive research opportunities throughout Boston. @massgeneralnews youtube.com/watch?v=mN3hQ3Vb…
Cameron Sadegh retweeted
We are delighted that our story on neonatal CSF clearance through the choroid plexus is published in @NatureComms. rdcu.be/cdPKY New data since the preprint include concentrations of 5 key CSF ions across development.🧠Next time you make aCSF, take a look at TableS1!🤩
The choroid plexus is thought to secrete CSF, but our new study shows that's not always the case! It helps to clear CSF before adult outflow routes mature. Led by Huixin (@Huixin_BJ) and Ryann (@ScienceDame). Preprint @biorxivpreprint. @BostonChildrens
biorxiv.org/cgi/content/shor…