ALT Representative 3D reconstructions of brain ventricles from control and high-dose AAV2/5-injected pups at 2, 5, and 7 days post-injection (P2.5, P5.5, P7.5). Quantification of total ventricular volume across time points. (n = 3 per condition)

ALT Representative coronal sections at the level of the posterior anterior commissure (pAC; dashed outline) showing lateral ventricle morphology in P7.5 brains following P0.5 ICV injections.

ALT Blake Zhou Sunday, 11/16, 8am-12pm. Presentation Number: PSTR053.24/ A22 Location/Room: A22 SDCC Halls B-H Arjun Rajan Sunday, 11/16, 1pm-5pm. Presentation Number: PSTR102.04/A40 Location/Room: A40 SDCC Halls B-H Luke Liu + Ryann Fame Tuesday 11/18, 1pm-3:45pm. Session Number: Nanosymposium NANO040 Session Title: Choroid Plexus and CSF Biology Location/Room: SDCC Rm 24A Nano040.04; Nano040

ALT https://www.science.org/doi/10.1126/scitranslmed.adq1810

ALT Fig. 1 | Components of the cerebrospinal fluid (CSF) system change across timeof day. A The major components of the CSF system include CSF, choroid plexus, andcircumventricular organs. These systems change their properties across time of day,including those listed below each component. B Multiple inputs affect the CSFsystem across time of day.