@LehtinenLab

basic & translational research on CSF-based signaling & choroid plexus • find us @HMS_Neuro & @BostonChildrens Pathology Dept • // account run by lab members

 Boston, MA
childrenshospital.org/research/labs/lehtinen-laboratory
Joined December 2019
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Lehtinen Lab retweeted
Peter Kalugin@pnkalugin
Aug 7
MORSE is out now in Neuron, with an expanded dataset: sciencedirect.com/science/ar… Using crosstalk to our advantage, we demixed norepinephrine & dopamine's binding at each other’s sensors to simultaneously quantify their release from locus coeruleus with resolution in the tens of nM.
Peter Kalugin@pnkalugin
27 Jan 2025
I’m thrilled to share our preprint presenting MORSE: a new way to simultaneously and quantitatively track patterns of neuromodulators/neuropeptides in vitro & in vivo using spatially multiplexed 3D imaging of 10+ green optical sensors on a microendoscope. biorxiv.org/content/10.1101/…
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New BioRxiv Post‼️ A Multi-Modal atlas combining human pathology, mouse modeling, transcriptomics, and advanced imaging. Check out the pre-print here: biorxiv.org/content/10.64898…

Multi-modal choroid plexus pathology in aging and Alzheimer’s disease

Brain barriers, cerebrospinal fluid (CSF) dynamics, and peripheral factors are implicated as significant contributors to Alzheimer’s disease (AD). The choroid plexus (ChP) is a blood-brain interface...

biorxiv.org
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We are grateful to all collaborators for their contributions to the study led by @Huixin_BJ & Peter Lotfy, Benjamin Englert & @JanieOberhauser, and co-senior authors: @ordovas_phd, @liisamyllykang1, @andcyang, and @LehtinenLab.
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Special thank yous to: @DrEllaOfScience, Pekka Karhunen, Deidre Jansson, Danny Reich, @wysscoray, Dorothy Schafer, David Holtzman, and their labs.
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🌟 Review led by @ScienceYael on apocrine secretion at the choroid plexus: evidence across imaging/proteomics🔬, regulatory cues, and CSF proteome impact
Ya'el Courtney, PhD@ScienceYael
16 Jul 2025
🔬 Calling #CellBiology and #EpithelialCell enthusiasts! My new review article w @LehtinenLab dives into a fascinating, somewhat niche, but critical secretory mechanism by the Choroid Plexus (ChP): apocrine secretion! link.springer.com/article/10…

Apocrine secretion by the choroid plexus

Fluids and Barriers of the CNS - The choroid plexus (ChP) epithelium secretes cerebrospinal fluid (CSF) and signaling factors that influence brain development. In addition to classical secretory...

link.springer.com
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New from our lab: in mice, maternal psychedelics reach embryonic CSF within minutes, activate the choroid plexus, and alter development with adult behavior effects. Thread🧵👇
Ya'el Courtney, PhD@ScienceYael
1 Oct 2025
🚨 Psychedelics in pregnancy - can a single dose reach the embryo and matter? Yes. In mice they hit embryonic CSF within minutes, activate choroid plexus→CSF axis, & shift cortical development w adult behavioral signatures. @LehtinenLab Preprint: biorxiv.org/content/10.1101/… 1/13

Gestational psychedelic exposure disrupts brain development and offspring behavior in mice

Despite increasing non-medical use and clinical investigation of psychedelics, the consequences of prenatal exposure remain unknown. In mice, maternal lysergic acid diethylamide (LSD; 0.3 mg kg−1)...

biorxiv.org
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Our July issue is now live! nature.com/neuro/volumes/28/…
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My first journal cover :) nature.com/neuro/volumes/28/… Volume 28 Issue 7, July 2025 @NatureNeuro @LehtinenLab
Cover of the July 2025 issue of Nature Neuroscience (Vol. 28 No. 7), featuring a high-resolution confocal microscopy image of the embryonic mouse fourth ventricle choroid plexus, highlighted in cyan and magenta on a black background. The title reads: “Choroid plexus secretion reshapes brain development.”

ALT Cover of the July 2025 issue of Nature Neuroscience (Vol. 28 No. 7), featuring a high-resolution confocal microscopy image of the embryonic mouse fourth ventricle choroid plexus, highlighted in cyan and magenta on a black background. The title reads: “Choroid plexus secretion reshapes brain development.”

Screenshot of a webpage from nature.com describing the cover story of the July 2025 issue of Nature Neuroscience. The text explains that the cover image shows the choroid plexus of an E16.5 mouse stained for AQP1, revealing how apocrine secretion influences CSF composition and brain development. Technical details include the use of a Zeiss LSM 710 microscope with AI-based denoising and image processing. The image is credited to Ya’el Courtney, Boston Children’s Hospital, and the cover design to Marina Spence.

ALT Screenshot of a webpage from nature.com describing the cover story of the July 2025 issue of Nature Neuroscience. The text explains that the cover image shows the choroid plexus of an E16.5 mouse stained for AQP1, revealing how apocrine secretion influences CSF composition and brain development. Technical details include the use of a Zeiss LSM 710 microscope with AI-based denoising and image processing. The image is credited to Ya’el Courtney, Boston Children’s Hospital, and the cover design to Marina Spence.

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Led by @ScienceYael and out today in @NatureNeuro: the brain's fluid-secreting organ — the choroid plexus — can reshape neural development through a powerful, little-known process. & it can be hijacked by serotonergic drugs like LSD. 🧠👇 A thread rdcu.be/eoaSY
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HUGE thank you to our collaborators on this project, without whom none of this beautiful work would be possible: Joshua Head, @Freshdipley, @NeilCDani1, Olga Chechneva, @MJHoltzmanlab, @csadegh, and Towia Libermann. @BCH_InTheNews
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Funded by @NIH, @NSF, @HHMINEWS, @BostonChildrens, @iddrc_bch, @SimonsFdn  Autism Research Initiative, @harvardbrainsci, @NYSCSF, and more! Grateful to the public and private institutions that made this possible.
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