Metabolism, ribosomes, running fast and slow. PhD O'Shea Lab, postdoc @mvh_lab. Assistant Professor @Duke_PCB - Darnell Lab opens September 2024!

Joined September 2017
Truly moved and delighted to announce that @chidley_chris and I will open labs this September at @Duke_PCB ! The Darnell lab will be delving deep into how amino acid limitation perturbs the ribosome at specific codons...
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Alicia Darnell retweeted
Applications are open for early-career researchers to attend our workshop on “Revisiting Metabolic Fundamentals” April 26-29, 2026 in East Sussex, UK. biologists.com/workshops/apr…
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📣In a collaboration with the @amcdarnell , we discuss the complexity of the ribosome ubiquitin code and what the field has done to crack it! "The ribosome ubiquitination code: fine-tuning translation under stress" Read it here: sciencedirect.com/science/ar…
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Alicia Darnell retweeted
My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15
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“We dissent to Administration policies that undermine the NIH mission, waste public resources, and harm the health of Americans and people across the globe.” #standupforscience
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Our RNA-linked CRISPR approach is now published! Work led by fantastic graduate student in the lab, Patrick Nugent.
ReLiC is an RNA-linked CRISPR platform for dissecting RNA metabolic processes, revealing key regulators of RNA splicing, translation and decay. @arvind_rasi nature.com/articles/s41592-0…
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Alicia Darnell retweeted
I discuss the urgent crisis from the loss of federal support of science in the US and recent clinical gene editing breakthroughs with @WalterIsaacson & @amanpour on @AmanpourCoPBS, airing on @PBS tonight at 11 pm ET, and on @cnni earlier today. Pls share! youtube.com/watch?v=8YhJM6zx…
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Alicia Darnell retweeted
We are excited to announce our 2025 @UofUDMRC Postdoctoral Rising Stars in Metabolism Symposium! This is truly a unique opportunity to network, present your research, and enjoy the breathtaking views that Salt Lake City has to offer. Deadline is May 15th, 2025. Please share!
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Alicia Darnell retweeted
Fresh off the press…our latest study on the Structure of a Gcn2 dimer in complex with the large 60S ribosomal subunit | great collaboration with @inada_lab and Zaher lab. Data collected at @DCI_EM. PNAS pnas.org/doi/10.1073/pnas.24…
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Excited to share a new preprint, where we evaluate the functional contributions of serum for cancer cell proliferation. Inside: A broadly applicable serum-free media, Quantitative lipid uptake characterization, Evidence lipid scavenging > synthesis for cancer cell proliferation
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Come join us! Faculty position in tumor immunology at Duke. Joint search between the Dept of Integrative Immunology @ImmunologyDuke and our Dept of Pharmacology and Cancer Biology @Duke_PCB. academicjobsonline.org/ajo/j…
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To my science framily, As we reflect on this election season, I want to take a moment to acknowledge that things may not have gone as we had hoped or expected. I wish I was shocked that America did not elect its first woman and woman of color to the presidency but I am angry and disappointed. I know times like these can stir a mix of emotions and concerns. I, too, share fears for the future of science, federal support for the marginalized and elderly, and the rights of my family and loved ones. In moments like this, I am especially grateful for each of you. Your diverse values, perspectives, and individual journeys add incredible strength to our community. Our communities are spaces where everyone’s unique contributions and insights are respected and valued, and I am deeply appreciative of the care, dedication, and vision each of you brings. I see you, I hear you, and I grieve alongside you. Take a beat to rest and recover and then let’s continue to support one another, stay focused on the meaningful work we’re doing, and foster an environment where everyone feels empowered to thrive. Thank you for being who you are. Joy comes in the morning, as it always will. With gratitude, Donita
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Alicia Darnell retweeted
Excited to share the first research publication from our lab! Lipid availability influences ferroptosis sensitivity in cancer cells by regulating polyunsaturated fatty acid trafficking sciencedirect.com/science/ar…
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Alicia Darnell retweeted
Hi #cancer #metabolism twitter. New review from @CognetGuillaume: science.org/doi/10.1126/scia…. Has long been understood that tumors experience metabolic stress due to nutrient limitation in the tumor microenvironment. 1/7
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Alicia Darnell retweeted
Research Scientist position is open @ the UChicago Metabolomics Platform. Exciting position to work with cutting edge instrumentation to perform metabolomics, lipidomics and stable isotope tracing experiments! Please RT and forward onto anyone interested! uchicago.wd5.myworkdayjobs.c…
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Alicia Darnell retweeted
Excited to share some work from my postdoc! In our recent preprint (w/ @gregorybritten @GeneWeiLiLab Sean Hackett and Mick Follows), we ask how to use proteomic data to estimate in vivo reaction rates? (1/n)
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📢Super excited to announce that the Chidley lab will open @Duke_PCB in September 2024, alongside the @amcdarnell lab🥳. The Chidley lab will use genetic screening approaches to dive into the world of transporter proteins and explore how they drive the movement of nutrients,...
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Thanks to @Duke_PCB for giving us this chance - especially chair @LeeZou8 and head of the search committee @kcw00d, who have both been so open and warm throughout our job search (as was the rest of the dept. – shout out to @TGOliver2 for hosting while we searched for houses!).
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We are so happy to have Durham and Duke/PCB as our new home and science family ❤️. Stay tuned for our lab website launches and reach out if you are interested in learning more! 🤓
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