@BeckmannLab

No longer updating this account. Find us @beckmannlab.🦋.social

 München, Bayern
genzentrum.uni-muenchen.de/research-groups/beckmann/index.html
Joined April 2018
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  • Following193
  • Followers2.1K
65Media
Read Rosales-Hernandez et al. doi.org/10.1038/s44318-025-0… and Zerbes/Colina-Tenorio et al. doi.org/10.1038/s44319-024-0… to find out about delivery of the Rieske protein after Bcs1 transport to Mar26 and MICOS for bc1 complex assembly.

Mechanistic insights into Bcs1-mediated mitochondrial membrane translocation of the folded Rieske...

The EMBO Journal - A functional mitochondrial respiratory chain requires coordinated and tightly regulated assembly of mitochondrial- and nuclear-encoded subunits. For bc1 complex (complex III)...

link.springer.com
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First structure of a H/ACA snoRNP acting in ribosome synthesis. In a great collaboration with the Hurt lab, we provide a detailed structural and biochemical view of the snR30 snoRNP guiding local 18S rRNA subdomain folding. 👇👇👇
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Our results finally explain the essential role of snR30 snoRNA! Check out the details in our preprint to find out more 👉👉👉 biorxiv.org/content/10.1101/… #ribosome #cryoEM #RNA

H/ACA snoRNP guides ribosomal RNA subdomain folding in a satellite particle before joining the core...

During synthesis, modification and maturation of the ribosomal RNA, correct subdomain folding without additional guidance poses a major challenge. An essential H/ACA snoRNP, snR30, was observed to be...

biorxiv.org
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Authors including @jingdongcheng report cryo-EM structures revealing how antibiotic tigecycline can also target human mitoribosome. nature.com/articles/s41467-0…
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Fresh out of the oven, our collaboration with the Kopito Lab - UFL1(E3) modifies, binds to, and dissociates the 60S subunit from the Sec61 translocon! #ribosome #cryoEM
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Check out the the full story here: nature.com/articles/s41586-0…
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Also check out the paper by @zeqiraj and @YKulathu: nature.com/articles/s41586-0…
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🎉We are thrilled to share our exciting new collaboration with @inada_lab and @jingdongcheng on how Otu2 recognizes and deubiquitinates 40S ribosomes after translation. Here is a thread with the most interesting findings:👇 #ribosome #ubiquitin #cryoEM
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Otu2 can bind to 40S during cytoplasmic ribosome biogenesis and all stages between ribosome recycling and start-codon recognition, but becomes a highly specific enzyme for translational reset during recycling/(re)initiation by removing mono-ubiquitin present on eS7.
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For a more detailed look, check out the paper now👉 nature.com/articles/s41467-0…

Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2

Nature Communications - Otu2-driven deubiquitylation of ribosomal protein eS7 impacts translational efficiency. Here, the authors provide the molecular basis for recognition of monoubiquitinated...

nature.com
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Beckmann Lab retweeted
Green Lab@GreenLabJHMI
7 May 2023
Turns out MutS2 just doesn’t cut it ✂️ despite it having an SMR domain! Our latest collaboration with the @BeckmannLab characterizing the role of MutS2 in splitting stalled ribosomes in B. subtilis. biorxiv.org/content/10.1101/…

B. subtilis MutS2 splits stalled ribosomes into subunits without mRNA cleavage

Stalled ribosomes are rescued by pathways that recycle the ribosome and target the nascent polypeptide for degradation. In E. coli , these pathways are triggered by ribosome collisions through...

biorxiv.org
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Let's rotate! Thanks to the great Hurt lab and @BeckmannLab, our story on the 60S ribosome biogenesis is finally out in EMBO reports. We find the 5S RNP in a new rotate conformation when stably incorporate into the nucleolar pre-60S. #cryoEM #ribosome doi.org/10.15252/embr.202356…
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Beckmann Lab retweeted
QMB Munich@MunichQbm
24 Feb 2023
Its online:🥳🎊🎉 Check out the @MathWorksAI user story🍻 de.mathworks.com/company/use… about our (@BeckmannLab, @hopfnerlab) DL based Cryo-EM image analysis tool (nature.com/articles/s41598-0…). Thank you @MathWorks for the great support!👍👍

Ludwig Maximilian University Develops Deep Learning System to Measure Ice Thickness in Cryo-EM...

Ludwig Maximilian University used Deep Learning Toolbox and MATLAB Compiler to create a standalone application that automatically screens ice thickness in cryo-EM samples.

de.mathworks.com
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Keeping up the momentum, we're excited to share the final version of our story about RQT-driven ribosomal splitting 🎉 🎉 Shout out to @KaBe__01, @ThomasB08006066, @inada_lab and everyone involved! Read on to learn more👇🏻👇🏻👇🏻 #cryoEM #ribosome #RQT
Beckmann Lab@BeckmannLab
20 Apr 2022
Pull the ripcord to clear the traffic jam: RQT splits collided #ribosomes by engaging the emerging mRNA. Check out our new story at #bioRxiv: biorxiv.org/content/10.1101/…
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The Ski2-like helicase 1 subunit applies a pulling force on the mRNA which causes RQT to swivel between two conformations. This leads to the destabilization of the 40S subunit, resulting in subunit dissociation of the leading ribosome.
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Check the full story here 👉🏻👉🏻👉🏻nature.com/articles/s41467-0…
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