@Muir_Lab

(Extra)Cellular Cancer Biology @UChicagoCCB.

 Chicago, IL
themuirlab.org
Joined January 2014
  • Tweets1.2K
  • Following2.2K
  • Followers2.8K
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We at @PanCAN were pleased to see the release of the updated @NCCN Pancreatic Adenocarcinoma Guidelines.
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I’m excited to share new work out of the lab at @NYULangone led by @kenjifujihara! We took a first principles approach to evaluating #ferroptosis induction for cancer therapy via targeting the SLC7A11-glutathione-GPX4 axis. biorxiv.org/content/10.64898…
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Announcing our 2026 CMH Postdoctoral Rising Stars Symposium on Wednesday, September 2! To apply for this opportunity, scan the QR codes on the flyer or visit our track links: Metabolism (shorturl.at/rjV1N) and Health Behaviors (shorturl.at/ayq8p). Help spread the word
This is an image advertising the CMH Postdoctoral Rising Stars Symposium on Wednesday, September 2. There are two tracks to choose from, Metabolism and Health Behaviors and there are QR codes for both track applications. Applications are listed as due on Friday, April 24.

ALT This is an image advertising the CMH Postdoctoral Rising Stars Symposium on Wednesday, September 2. There are two tracks to choose from, Metabolism and Health Behaviors and there are QR codes for both track applications. Applications are listed as due on Friday, April 24.

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Thrilled to share our work in press @jclinicalinvest where we modernize a hallmark experiment originally performed by the Coris by performing intra-operative metabolite sampling in lung cancer patients jci.org/articles/view/198821
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Excited to announce that registration is officially open for #METPHYS2026! All meeting details can be found here: sablesys.com/metphys-the-met…
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Muir Lab retweeted
Lydia Finley@lydfinley
Jan 7
Out today 🙌 new work from the lab in which we show that p53-driven senescence enables phospholipid headgroup recycling to help sustain the increased synthesis of membrane phospholipids of senescent cells nature.com/articles/s41556-0…

p53 increases phospholipid headgroup scavenging in senescence

Nature Cell Biology - Yashinskie, Zhu and colleagues show that p53 activation triggers increased synthesis and accumulation of phospholipids, with enhanced activation of autophagy and lysosomal...

nature.com
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I love this concept. Although framed around #aging research, I think it can extend beyond that. We can use a synthetic approach, to study basic principles of cell biology and potentially mitigate human disease by engineering unique bacterial enzymes. science.org/doi/10.1126/scia…

Xenotopic synthetic biology: Prospective tools for delaying aging and age-related diseases

Using enzymes from lower organisms, which are not encoded in the mammalian genome, delays aging and age-related diseases.

science.org
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New! Online now: A metabolic atlas of mouse aging dlvr.it/TPSYYS
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New @CR_AACR study by @Cosimo_Commisso The Aging Microenvironment is a Determinant of Immune Exclusion and Metastatic Fate in #PancreaticCancer aacrjournals.org/cancerres/a…
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🗽Save the date! March 24, 2026 Cancer Metabolism and Signaling Symposium @NYASciences co-organized by @LyssiotisLab @RichPossemato Speakers: @lab_manning @bensahralab @MarcusDGon @airdlab @KanarekNaama @JaviGBermudez @SantoshVardhana Josh R, Erika P +short talks from abstracts!
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Happy to share our new review (featuring Joe Longo and McLane Watson) on how T cells use nutrient allocation to optimize immune responses. @VAIMetabolism @VAInstitute sciencedirect.com/science/ar…
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Big news from the #Glytsoulab today!✍️Our research on drug resistance in leukemia is published in @ScienceAdvances. Targeting OPA1 can help overcome therapy resistance in AML, including the most challenging cases. 📖 science.org/doi/10.1126/scia…

Small-molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in...

Targeting OPA1-mediated mitochondrial ultrastructural adaptations circumvents therapy resistance in acute leukemia.

science.org
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Our new work in @Cell_Metabolism by @ArtemAKhan describes three new SLC transporters, including SLC25A45, a mitochondrial transporter for methylated amino acids that is essential for carnitine synthesis and fasting adaptation. @RockefellerUniv cell.com/cell-metabolism/ful…
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This cool @ScienceMagazine paper links extracellular pH milieu (acidosis) to an intra-cellular oncogenic signaling pathway & metabolic rewiring in #PancreaticCancer. Acidosis orchestrates adaptations of energy metabolism in tumors science.org/doi/10.1126/scie…
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Wonderful talk by @DebVendramini @HenryFordHealth on adaptation & plasticity of the stromal and #CancerAssociatedFibroblasts microenvironment in driving immune suppression in #PDAC #AACRPan25 @RAFrancescone
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Location, location, location! Now out in @NatureCancer, the final version of our study showing how a tumor's anatomic site can impact the function of driver gene mutations, using SMAD4 inactivation in pancreatic cancer as a clin. relevant example: nature.com/articles/s43018-0…. (1/3)
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Excited to share the lab’s first pre-print! Here we investigate how #nutrient availability regulates #ECM composition, mechanical properties and biological activity. biorxiv.org/content/10.1101/…

Nutrient availability-driven changes in extracellular matrix biochemical and mechanical properties...

The extracellular matrix (ECM) provides key biochemical and biomechanical cues that govern fundamental cellular processes, including growth and migration. ECM dysregulation and altered cell-matrix...

biorxiv.org
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Check out the most recent work from @ColinSh21573670 and the Muir Lab!! Super exciting stuff!
Muir Lab@Muir_Lab
9 Sep 2025
Super excited to share our new preprint from @ColinSh21573670 on how the tumor microenvironment causes drug resistance in pancreatic cancer: biorxiv.org/content/10.1101/…

Tumor nutrient stress gives rise to a drug tolerant cell state in pancreatic cancer

Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival...

biorxiv.org
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Congrats! @Sunhee_Jung_ @HosungBae Wonsuk and co-authors. We reported in this @NatMetabolism intriguing effects of dietary inulin on changing small intestinal gut microbial fructose metabolism, leading to protective effects on liver. Thanks, reviewers. nature.com/articles/s42255-0…

Dietary fibre-adapted gut microbiome clears dietary fructose and reverses hepatic steatosis

Nature Metabolism - The dietary fibre inulin is shown to promote fructose catabolism by the small intestinal microbiome, thereby mitigating fructose-induced hepatic lipogenesis and steatosis.

nature.com
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New study alert! Coming out today @ImmunityCP, we describe crosstalk between dysfunctional mitochondria and telomere damage in the context of tumor-induced T cell dysfunction. I'll tell you how we did it: cell.com/immunity/fulltext/S… 1/

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

The functional state of tumor-infiltrating lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy. Rivadeneira et al. demonstrate that mitochondrial ROS accumulat...

cell.com
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