DNA repair & topoisomerases • Feminist
Cambridge, England
Joined February 2012
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Almudena Serrano-Benítez retweeted
🚨 Fully funded #PhD opportunity! 🚨
Passionate about cancer research? Join @MadziaCrossley's team to investigate how R-loop dysregulation contributes to cancer.
📍 Cambridge, UK
💰 Fully funded
📅 Apply by 24 March 2025
cruk.cam.ac.uk/vacancies/phd…
Almudena Serrano-Benítez retweeted
Happy to share our newly published article in Nature Communications! In this work, we uncover the novel role of KLF5 in sensitizing cells to ATR inhibition, identifying it as a synthetic lethal partner with the tumor suppressor ARID1A. @SPJacksonGroup
nature.com/articles/s41467-0…
Almudena Serrano-Benítez retweeted
Genome engineering excelled at small nucleotide changes, but large edits remained challenging. Recent innovations are changing this.
We reviewed the field of structural variant engineering @NatureGenet 🧬
@JulianeWeller @TVanderstichele @LeopoldParts
nature.com/articles/s41588-0…
Almudena Serrano-Benítez retweeted
Transcriptome-scale RNA-targeting CRISPR screens
reveal essential lncRNAs in human cells
cell.com/cell/fulltext/S0092…
Almudena Serrano-Benítez retweeted
las temporeras y temporeros de huelva también necesitan ayuda. sus chabolas se han destrozado
Almudena Serrano-Benítez retweeted
Thrilled to see our work on murine oesophageal #Epithelioids published in @NatureGenet, after many years of hard work alongside @AlbertHerms during our postdoc at Phil Jones' lab @Sangerinstitute and built on the foundational work by @MariaPAlcolea
nature.com/articles/s41588-0…
Almudena Serrano-Benítez retweeted
The @duxin_lab , with @NilssonLabCph, uncover #PolK's dual roles in #DNAdamage bypass. Using #CRISPR & #Xenopuseggextracts, they show PolK’s catalytic & non-catalytic functions -repairing minor groove lesions and aiding Polζ in overcoming #chemotherapeutic-induced DNA lesions!⬇️
Almudena Serrano-Benítez retweeted
Our single-cell, pan-cancer analysis of open chromatin in human cancers, done in collaboration with TCGA and the Chang and Corces labs (among others including Illumina), is out in Science today. Congrats to Laksshman Sundaram and all authors! science.org/doi/10.1126/scie…
Almudena Serrano-Benítez retweeted
Our latest paper -> On identifying the mutations driving clonal hematopoiesis using machine learning models - BoostDM-CH
Great team work by @SantiDemajo, @JoanEenric, @fmuinos et al
Tweetorial 👇
‼️ The final version of our article “Identification of Clonal Hematopoiesis Driver Mutations through In Silico Saturation Mutagenesis” is out in Cancer Discovery @CD_AACR: aacrjournals.org/cancerdisco…
Learn more about our findings in this thread 👇🏽
Almudena Serrano-Benítez retweeted
Thrilled to share my lab’s latest work, out recently in Mol Cell, on a role for HLTF in G4 resolution. Led by the amazing Gongshi Bai with essential contributions from @davidcortez, Brandt Eichman, @CejkaLab and @BoultonLab. See: authors.elsevier.com/a/1jbBg…
Almudena Serrano-Benítez retweeted
Excited to share our lab's latest research, out today @NatureSMB, which describes how 53BP1 controls DNA Repair in class-switching B cells & BRCA1 mutant cancers. Final article can be found here:
nature.com/articles/s41594-0…; & the following thread walks you through the details
Our lab's latest is now out on BioRxiv. In this work we set out to understand how 'shieldin' regulates #DNArepair, focusing on its physiological function in B cells & pathological contributions to BRCA1-mutant cancers. Some background & take-home msgs (1/) biorxiv.org/content/10.1101/…
Almudena Serrano-Benítez retweeted
Many thanks to the @MRC_LMB (the people & their science) & @UKRI_News for this amazing unbelievable opportunity. I'm ecstatic beyond measure. It's a bit intimidating to be in such a great place full of groundbreaking minds but hope I can contribute with my share to new research!
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Almudena Serrano-Benítez retweeted
RAD51 protects abasic sites to prevent replication fork breakage dlvr.it/TCHxrp
Almudena Serrano-Benítez retweeted
Esto es El Congo.
Esto son las minas para extraer los minerales para que occidente tenga progreso.
Es una mina que ha colapsado, debido a la manera infrahumana en la que trabajan, muchos son niños.
Después cuando huyen de sus países,no los quieren aquí.
Almudena Serrano-Benítez retweeted
Online Now: RNA interacts with topoisomerase I to adjust DNA topology dlvr.it/TCBkDV
Almudena Serrano-Benítez retweeted
🔥🔥🔥 PREPRINT 🔥🔥🔥
Wanna know how your favorite gene affects double-strand break repair outcome/CRISPR-Cas9 gene editing?
Check this out! ⬇️ #REPAIRome
biorxiv.org/content/10.1101/…
Almudena Serrano-Benítez retweeted
In vitro, multiple #DNA_repair proteins Ku load from DNA ends on linear DNA, eventually covering it. Yet, in cells, only one Ku is found per DNA end at double-strand breaks. What restricts Ku entry on chromatin? doi.org/10.1016/j.celrep.202…
Almudena Serrano-Benítez retweeted
Check out our latest paper showing that HLTF removes Cas9 from DNA, explaining phenotypic differences when using the two Cas9 nickase variants. Important for gene editing! Thanks to @giordano_reg & Rosaria and @MartinJinek @taekjip @nussenza
nature.com/articles/s41467-0…
