@CortesLab

We study DNA topology, action of topoisomerses and DNA break repair to understand genome organization, dynamics and stability @CNIO https://nitter.cf/t.co/dnM8T3kdNr

 CNIO (Madrid, Spain)
Joined December 2019
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  • Following386
  • Followers855
4Media
New paper out in @ScienceAdvances TOP2B activity is locally inhibited during the estrogen response to favour the accumulation of DNA supercoiling and regulatory chromatin contacts that trigger transcriptional induction science.org/doi/10.1126/scia…

TOP2B modulates DNA supercoiling and chromatin contacts during transcriptional induction

During the estrogen response, TOP2B activity controls DNA supercoiling to shape chromatin contacts and regulate gene induction.

science.org
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No DNA breaks involved ... just topoisomerases doing their job
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It's been a long journey ... Huge congratulations to everybody involved @CNIOStopCancer @cabimer, specially the leaders of all this @JoseT86910859 @GMillanZambrano And thanks to collaborators @AguileraLab RS Williams Lab and Mario García Domínguez
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📢Please spread the word📢 Several postdoc positions (wet and computational) open in the lab to work on different research lines (see thread) We seek highly motivated candidates to join our team @CNIOStopCancer cnio.es/en/research-innovati… E-mail CV and brief motivation statement
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2. DSB repair and genome instability mechanisms. Following on our recent REPAIRome study science.org/doi/10.1126/scie… Funding: @AgEInves

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels)...

science.org
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- Topoisomerase-induced DNA breaks in cancer chemotherapy. Building on the traditional research line of the lab nature.com/articles/nature08… science.org/doi/10.1126/scie… Funding: @CaixaResearch and @ContraCancerEs

A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

Nature - The mechanism of topoisomerase action involves making a transient break in DNA. If the topoisomerase makes a break near another DNA lesion, the break can persist, with the topoisomerase...

nature.com
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Our REPAIRome study finally out today in @ScienceMagazine !!! science.org/doi/10.1126/scie…

A comprehensive genetic catalog of human double-strand break repair

The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels)...

science.org
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Congratulations to all the people involved, also in @ChromDyn @rfleiro @gjmacintyre labs @CNIOStopCancer Specially leading authors @ErnestoLDA1811 Israel Salguero and @DanielGLL_ Very proud of you!!!
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Check out our web tool to see interactive networks of DSB repair genes, browse your gene of interest for its contribution to DSB repair profiles and analyze functional relationships based on similarities in repair patterns repairome.bioinfo.cnio.es Enjoy!!!

REPAIRome

repairome.bioinfo.cnio.es
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Researches at #cniostopcancer create the ‘human repairome’, a catalogue of DNA ‘scars’ that will help define personalised cancer treatments. Published in @ScienceMagazine  bit.ly/4fGk4CV

CNIO researchers create the ‘human repairome’, a catalogue of DNA ‘scars’ that will help define...

You can always be judged by your scars. This is the idea that sums up one of the new breakthroughs in basic and biomedical research published today in the journal Science, an achievement of the...

cnio.es
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Replying to @CNIOStopCancer @ScienceMagazine
🧬The human repairome, REPAIRome, will allow researchers around the world to check out how each of the 20,000 human genes affects DNA repair. Authors: @CortesLab @ErnestoLDA1811 Israel Salguero Daniel Giménez et al.  Funding: @CienciaGob @AgEInves @Europarl_ES
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Replying to @CNIOStopCancer @ScienceMagazine @CortesLab @ErnestoLDA1811 @CienciaGob @AgEInves @Europarl_ES
The repairome is ‘a platform for new discoveries', which has already helped to detect new genetic mechanisms involved in kidney cancer, and will allows progress ‘towards full control of CRISPR-Cas gene-editing technologies’. Infographic: @CireniaSketches  bit.ly/4fGk4CV
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Have a look at our review in @MolecularCell . We explore how histone modifications serve as integrators of genome activity, mediating communication between distinct DNA procesess. authors.elsevier.com/a/1kS2f…
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En nuestro grupo en @cabimer investigamos sobre el síndrome por deficiencia en el gen CHD8. Buscamos a personas diagnosticadas con alteraciones en este gen, para asociarnos, intercambiar experiencias y aumentar el conocimiento sobre el síndrome.👇👇
Raras pero Reales
@RarasReales
21 Nov 2024
Yeray ha sido diagnosticado de síndrome #CHD8, una enfermedad que solo sufren 167 personas en el mundo, 4 ellos en España. “Quiero dar visibilidad a esta enfermedad para ayudar a mi hijo", explica su madre. laopiniondezamora.es/castill…

Vivir con una enfermedad rara: el caso de Yeray, que solo sufren 167 personas en el mundo

El palentino de cuatro años sufre una extraña patología, el síndrome CHD8, para la que su familia reclama más visibilidad, investigación y apoyo

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Cortés Lab retweeted
Rafa F Leiro@rfleiro
13 Nov 2024
Many thanks to @FundlaCaixa @CaixaResearch for the incredible support to work on this important problem together with Borja Ibarra @3M_lab and Cristina Ugalde Postdoc positions will be opening soon! Exciting times ahead!
CaixaResearch
@CaixaResearch
13 Nov 2024
🧬Errores en la replicación del ADN de las mitocondrias —un componente celular— se asocian a trastornos neurodegenerativos como el alzhéimer y el párkinson. Con una ayuda #CaixaResearch, @rfleiro investigará cómo contribuyen estos errores a las patologías, lo que permitirá desarrollar nuevas aproximaciones terapéuticas. tinyurl.com/5n7etfrr
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Cuatro investigadores del #CNIOStopCancer reciben financiación @CaixaResearch. cnio.es/noticias/cuatro-inve…

Cuatro investigadores del CNIO reciben financiación de la Fundación “la Caixa”

Guadalupe Sabio, Felipe Cortés y Rafael Fernández dirigen respectivamente cada uno de los tres proyectos de investigación del Centro de Investigaciones Oncológicas (CNIO) seleccionados en convocato...

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Very excited with the opportunity to take our basic discoveries on DNA topology and topoisomerase function to possible applications in our fight against cancer with this #CaixaResearch grant Thanks @CaixaResearch! Opportunities to join this project @CNIOStopCancer will follow
CaixaResearch
@CaixaResearch
13 Nov 2024
🧬 Debido a su rápido crecimiento, las células tumorales son más propensas a acumular nudos y enredos en su ADN. Con una ayuda #CaixaResearch, @CortesLab estudiará cómo pueden estos errores usarse para desarrollar nuevas herramientas de diagnóstico y tratamiento del cáncer.💊 tinyurl.com/59ujr7e2
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Replying to @CaixaResearch @FundlaCaixa @FundlaCaixaPT @carvalho_ago @CoralBarbasAr @ManelEsteller @VHIR_ @icn2nano @UniBarcelona @pmaciel_icvs @piacosma @Pasquali_Lab @LickertHeiko @Gsabiolab @GimenezMarques @VidalPuig @mromerogomez
16/ 🏆Llegamos al ecuador de la ceremonia con los 6 reconocimientos en oncología, entregados por: 🔵 Juan Ramón Fuertes, director general adjunto @FundlaCaixa 🔵 Ignasi López, director del Área de Relaciones con Instituciones de Investigación y Salud @FundlaCaixa
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