Sébastien Britton retweeted
The @RoukosVassilis lab led a new and detailed study of Topoisomerase II contribution to #3Dgenome folding in human cells and in different cell cycle phases -- my group and the @MundlosLab contributed analyses/data. The paper is now published in @MolecularCell ...1/n
Sébastien Britton retweeted
‼️highlight alert‼️
Thanks @CNRSchimie for highlighting this @icmub work done in collaboration with @agranzhan @institut_curie @SebBritton1 @IpbsToulouse Nicolas Chéron @Chimie__ENS and Lukas Trantirek @CEITEC_Brno
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Sébastien Britton retweeted
Group leader in Infection Biology @IpbsToulouse
The IPBS-Toulouse recruits a Group leader in Infection Biology
jobrxiv.org/job/institute-of…
#ScienceJobs #job
jobrxiv.org/job/institute-of…
Sébastien Britton retweeted
If you are a bright Ph.D. student working outside France around our research theme ipbs.fr/fr/mecanismes-epigen… @IpbsToulouse , here is a chance for you to contact us to apply for the open Excellence Eiffel Fellowship univ-tlse3.fr/venir-a-l-univ…
contact us before October 20th, 2024 !!
Sébastien Britton retweeted
Come join us as a postdoc in the JaJa lab at the Netherlands Cancer Institute if you are interested in the molecular mechanisms underlying telomere maintenance by ALT and in findings ways how to target ALT in pediatric cancer treatment.nki.nl/careers-study/vacanci…
Sébastien Britton retweeted
Our lab, @IpbsToulouse is looking for a motivated research engineer with fluency in French and English, interested in our research theme, ipbs.fr/fr/mecanismes-epigen…. Please apply here: emploi.cnrs.fr/Gestion/Offre…
Please retweet 🙏
Sébastien Britton retweeted
#ResultatScientifique 🔎 | Du nouveau sur la régulation des mécanismes de réparation de l’ADN
🤝 @CNRS @CNRS_Toulouse @UT3PaulSabatier @IpbsToulouse
✍️ @SebBritton1
📕 @CellReports | buff.ly/3ACUTAR
buff.ly/475vCeD
Sébastien Britton retweeted
1/7 Our latest preprint is out! 🚨 @Sour_Agrawal , @xiuhua_linwisc , @viveksusvirkar et al. discover human RPA is a critical telomerase processivity factor essential for telomere maintenance. This reshapes our understanding of human telomerase regulation. biorxiv.org/content/10.1101/…
Sébastien Britton retweeted
Have you ever wondered why some cell lines are easy to edit with CRISPR-mediated gene editing, while others are more difficult? Our paper is now online and offers an interesting answer: nature.com/articles/s41587-0…
Sébastien Britton retweeted
Our latest manuscript on a new cell cycle dependent control of dna repair. Started from a high resolution crispr screen of #ubiquitin system after IR: check table S2!
Also substrates of cyclin f through motif search!
science.org/doi/10.1126/scia…
Sébastien Britton retweeted
Optimized methods for mapping DNA double-strand-break ends and resection tracts and application to meiotic recombination in mouse ... biorxiv.org/cgi/content/shor… #biorxiv_genomic
Sébastien Britton retweeted
Happy to share a publication from the lab demonstrating that 53BP1 loss is a positive predictive biomarker for immune checkpoint blockade efficacy, with important implications for the treatment of PARPi-resistant ovarian and pancreatic cancers!
nature.com/articles/s41467-0…
Sébastien Britton retweeted
🔥🔥🔥 PREPRINT 🔥🔥🔥
Wanna know how your favorite gene affects double-strand break repair outcome/CRISPR-Cas9 gene editing?
Check this out! ⬇️ #REPAIRome
biorxiv.org/content/10.1101/…
In vitro, multiple #DNA_repair proteins Ku load from DNA ends on linear DNA, eventually covering it. Yet, in cells, only one Ku is found per DNA end at double-strand breaks. What restricts Ku entry on chromatin? doi.org/10.1016/j.celrep.202…
In this work, we identify the main barriers to Ku accumulation in chromatin: DNA-PKcs structurally retains Ku at DNA ends. If Ku enters chromatin, it is removed by a neddylation/FBXL12-dependent process. In S-phase, DNA end resection can remove Ku, even in excess.
Really proud of this one! Thanks to our collaborators @JoeLoparo lab for single-molecule experiments in Xenopus egg extracts, the kind reviewers, @CellReports for the pleasant publishing experience, and our funders @Liguevscancer31 @laliguecancer @FRM_officiel
These mechanisms are crucial: transcription is inhibited locally by Ku without DNA-PKcs, and FBXL12 is vital for the fitness of DNA-PKcs deficient cells. Our findings highlight the complex regulation of Ku, necessary to maintaining genome integrity.
Sébastien Britton retweeted
Our plasmid collection of 98 human DNA mismatch repair genes and their regulators is now available through @Addgene, together with another >200 plasmids from our lab. We hope they will be useful to the scientific community
see:
addgene.org/browse/article/2…
Sébastien Britton retweeted
Thrilled with #Embocitrullnation success @MAChristoLab thank you all the participants 🤗
Grand merci @IpbsToulouse @IsabelleSaves1 @ToulouseCancer
@GillesFavrecrct
That's already the end of this great @EMBOevents #EMBOcitrullination
Last session to award prizes of the best short talk and poster presentations, granted by the Fondation @ToulouseCancer in the presence of its director Prof. Gilles Favre
Sébastien Britton retweeted
Day 3 #EMBOcitrullination is not only about excellent science @EMBO it is also about moment of exchange in our wonderful city #Toulouse @Toulouse_CVB @Toulouse @Univ_Toulouse
Day 2 #Embocitrullination was all about great science #Cancer #tissueregeneration #citrullination #protemicstools and great food.
Looking forward for thrilling continuation today 😊