@CejkaLab

Our laboratory investigates mechanisms of DNA double strand break repair. Views own.

 Bellinzona, Switzerland
irb.usi.ch/petr-cejka
Joined November 2018
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Join us in beautiful Ventura for the 2025 GRC meeting, Mammalian DNA Repair: Fundamental Mechanisms to Human Biology grc.org/mammalian-dna-repair……… Great program, including keynotes from David Pellman and Maria Jasin. We will be selecting talks and poster slots soon. Apply now!
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Same here!
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Go for it! See you in the Other Place!
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November is here, but where is the snow?
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Very excited to present the latest preprint from our lab! "FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments" biorxiv.org/content/10.1101/… .

FIGNL1 inhibits homologous recombination in BRCA2 deficient cells by dissociating RAD51 filaments

Homologous recombination (HR) deficiency upon BRCA2 loss arises from defects in the formation of RAD51 nucleoprotein filaments. Here, we demonstrate that loss of the anti-recombinase FIGNL1 retains...

biorxiv.org
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I Switzerland, we have Pininfarina designed cable car with Swarowski crystals (Zermatt), but also this one in canton Uri. Operational and open for public use.
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Replying to @CejkaLab
@CejkaLab we are looking forward to your presentation at #Recombination25 in Crete next May🌞 Please RT to let your followers know that Talk Submission is open 🌟 To Register & Submit: bit.ly/4dKDwff
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We have a tenure-track professorship position in Cancer Biology focusing on genome stability, the ubiquitin system, and the animal/zebrafish cancer models: ntu.wd3.myworkdayjobs.com/en…
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Principal Investigator (PI) position available in @IFOMresearch to study #AGING & #Cancer : ifom.eu/en/job-opportunities… Join us in Milan to make a difference in this booming field! Please circulate this exciting opportunity 🚀🚀
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Val Grande National Park in Italy, just a few kilometers past the border from Switzerland. In the background the second highest mountain in the Alps, Monte Rosa.
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tinyurl.com/34vvz6x5 ⚡ See the latest paper from Prof. Cejka Lab out in @Nature on the mechanism of BRCA1 function in DNA end resection and DNA protection.📸 First authors : Dr. Maria Rosaria Dello Stritto (left) and Dr. Ilaria Ceppi (right). @nature @usiuniversity
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Study discovers new process for cells to repair DNA damage ntu.edu.sg/news/detail/study…

Study discovers new process for cells to repair DNA damage

A team of international researchers at the University of Oxford (Oxford) and NTU Singapore, has discovered a new process for repairing damaged DNA that is particularly relevant for patients undergo...

ntu.edu.sg
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Grotto America, a place where Ticinesi in the 1800s were meeting before leaving to America, was where we said good bye to our dearest colleagues Ananya and Giordano. Under very different conditions, they are both moving to excellent labs in the US, and we will miss them dearly.
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We are thrilled to present you our work on BRCA1-BARD1 @Nature showing that the complex has a direct role in long-range DNA end resection. With @CeppiIlaria @DelloStritto_MR and our collaborators @PabloHuertasLab @SylvieNoorderm1 and Seidel labs. nature.com/articles/s41586-0…
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See a related paper by the Sung lab and collaborators!
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I will be writing a review on DNA end resection with Raphael Ceccaldi. If you have a story coming out before the end of the year that you think could be highlighted, please do get in touch.
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When overseeing grant review applications, one particularly grumpy reviewer pointed out why we should care about a mechanism when we know the approach works in the clinics. Exactly, why bother understanding how the engine works when the car still moves—until it doesn’t.
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Thrilled to share my lab’s latest work, out recently in Mol Cell, on a role for HLTF in G4 resolution. Led by the amazing Gongshi Bai with essential contributions from @davidcortez, Brandt Eichman, @CejkaLab and @BoultonLab. See: authors.elsevier.com/a/1jbBg…
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How do you find a needle in a genomic haystack? Yeast yields some answers here, thanks to Xless Agnès Dumont, Nicolas Mendiboure, @JSavocco, @djost_physbiol et al. Free here for 50 days, or very similar preprint here: nitter.cf/aurelepiazza/status/17… Enjoy!
Molecular Cell@MolecularCell
22 Aug 2024
Online Now: Mechanism of homology search expansion during recombinational DNA break repair in Saccharomyces cerevisiae dlvr.it/TCFdY9
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