@alaederach

RNA Folding Bioinformatics, Science, and a bright sunny day in the alps.

 Chapel Hill, NC
ribosnitch.bio.unc.edu
Joined April 2008
  • Tweets1.8K
  • Following145
  • Followers1.2K
66Media
Data on Researchers’ Self-Reported Disability Status nexus.od.nih.gov/all/2022/12… Interesting read, I am glad to see @NIH highlighting this data!
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Alain Laederach retweeted
Yiliang Ding@YiliangDing21 Oct 2022
RNA G-quadruplex rocks!Our exciting story is finally out! Novel insights on how plants adopt RG4 in response to cold. nature.com/articles/s41467-0… @JohnInnesCentre @ERC_Research @BBSRC @GEN_ISP_JIC @HaopengYu @XiaofeiYang14 @Ilexpurpurea @sduncan015 @kitkwok6

RNA G-quadruplex structure contributes to cold adaptation in plants

Nature Communications - During evolution, plants have adapted to habitats with distinct temperature ranges. In this study, scientists report that a specific RNA structure motif, RNA G-quadruplex...

nature.com
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Alain Laederach retweeted
MC@CorleyTwin219 Oct 2022
DNA uses thymine (T); RNA uses uracil (U) instead. Why?? Somehow I only recently learned the reasons and it’s quite neat. And as is typical in biology there are still open questions about it 🧵
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I enjoyed Wah Chiu’s talk here at #ncrna2022, his work in collaboration @RDasLab on L-21 group I intron structure brought back excellent memories of misfolding RNAs!
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Excited to be at the #ncrna2022 meeting in person again, biggest turnout since this meeting started 25 years ago!
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Registration in open for the NC RNA 2022 tool and target meeting, with a great lineup of speakers. Please do consider registering at ncrna.web.unc.edu!!
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RNA structure landscape of S. cerevisiae introns biorxiv.org/content/10.1101/… Very nice preprint by @RDasLab and @RiboHipster on pre-mRNA structure, glad to see we aren't the only ones thinking structure has got to be doing something in those introns!

RNA structure landscape of S. cerevisiae introns

Pre-mRNA secondary structure is hypothesized to play widespread roles in regulating splicing of eukaryotic introns, but direct detection of such structure in vivo has been challenging. Here, we...

biorxiv.org
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Continuing with a truly outstanding slate of speakers @FASEBorg Dr. Silvia Ramos from @UNC_BCBP described some of her recent work defining the role of ZFP36L2 in regulating specific RNA targets in mice recently published in @NAR_Open #RNADecay #PCGE22
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Excited to attend @NC_RNA_Meeting October 13-14 in the triangle this fall. Check out ncrna.web.unc.edu for updates!
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Alain Laederach retweeted
Michael Love@mikelove15 Jun 2022
Replying to @alaederach
Why that’s Microtubule Associated Protein Tau Expressed in brain, complex splicing gtexportal.org/home/gene/MAP…
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Clearly the best way to get everyone in your lab to laugh is to make a joke at the expense of the PI! #science #RNA I think we are going to use this one on ribosnitch.bio.unc.edu
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Alain Laederach retweeted
Michael Love@mikelove13 Jun 2022
Replying to @alaederach
PSI = percent spliced in, a metric for how often a particular exon is included in the transcripts, for a given sample
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Our latest work on mRNA structure and splicing where Jaya Kumar in my lab predicted the footprint of the spliceosome on pre-mRNAs and used this in conjunction with endogenous structure probing to predict PSI in MAPT. elifesciences.org/articles/7…

Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous...

A novel model is presented that reconciles in-cell structure probing data with splicing regulatory elements to predict exon 10 inclusion of the Tau gene with high accuracy for 53 splice altering...

elifesciences.org
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Alain Laederach retweeted
FoxLabNC@FoxLabNC6 Jun 2022
Scott Allen @Sallen822 is now Dr Scott Allen! Fantastic thesis defense today. Up next for Scott is a postdoc @UNC_Biology with @alaederach and Kevin Weeks.
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Looking for postdocs to work at the interface of probabilistic and evolutionary models in remote homology. Position funded by @NSF
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Congratulations to Silvia Ramos MD on her promotion of Associate professor of Biochemistry and Biophysics! Read about her research and career. med.unc.edu/biochem/news/ram…
Silvia B. Ramos MD

ALT Silvia B. Ramos MD

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Alain Laederach retweeted
Chad Pecot, MD
@ChadPecot24 May 2022
🚨📢 Spread the word... The UNC RNA Discovery Center Has Launched!!! Stay tuned for a Twitter handle and many exciting initiatives @UNC_Lineberger @GladfelterLab @weekslab @materalab @alaederach @QiZhangLab @jesseraab @TheHectorFranco @TheFentonLab @dominguez_lab @RNASociety
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Great to have had @alaederach visit on invitation of @UMich CBI @NIGMS T32 training grant students; great to have everyone agree how fun a colleague Alain is! Sorry you won’t make it to next @RNASociety meeting - @umichrna groups will have a beer in your honor!
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Alain Laederach retweeted
Paul Gardner@ppgardne12 Apr 2022
Replying to @alaederach
The journal of RiboSNitches... ;-) – at Dunedin City, New Zealand
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