@RDasLab

Our lab seeks an agile and predictive understanding of how RNAs structurally code for information processing and replication in living systems.

 Stanford, CA
daslab.stanford.edu
Joined April 2019
  • Tweets263
  • Following103
  • Followers2.7K
54Media
Our paper with @eternagame, 5 AI teams, and cryo-EM collabs on de novo design of #RNA pseudoknots with #deeplearning is out in @ScienceMagazine ! Comes with a provocative commentary on RNA structure prediction by @TonyMustoe lab! doi.org/10.1126/science.aeg6… doi.org/10.1126/science.aek4…
Eterna@eternagame
Aug 27
We made the cover of Science! Congratulations to all the players and researchers who worked so hard on the OpenKnot project the last two years.
21
1
91
8,182
Finally, 3D #cryoEM structure of a nucleotide polymerizing #RNA that copies #RNA to #RNA: tC19z, evolved at LMB MRC 15 y ago! biorxiv.org/content/10.64898… @Szokoli_Deni Jason Hingey, Dan Haack, Vivian Wu @nickspellmon @navtejtoor @HHMIJanelia
20
3
67
5,707
We and @eternagame are joining the quest to find a molecule that can sustainably replicate itself. Pilot results on first 1000 designs are posted, next up will be million-design-scale expts. Come design at eternagame.org/labs/14660266 by Aug 31, 2026! #RNAworld
Eterna@eternagame
Aug 7
Our Replicase pilot results found that the catalytic activity and copyability of the 71-89 polymerase ribozyme can be improved! We have launched a new puzzle for finding a version that excels at both properties simultaneously. Comp methods are encouraged to submit designs!
Puzzle interface displaying both the secondary and tertiary structure of the ribozyme

ALT Puzzle interface displaying both the secondary and tertiary structure of the ribozyme

8
2
25
5,734
#RNA computational design groups around the world delivered! Congrats as well to @eternagame players who contributed the 240-nt pseudoknot targets -- and baseline RNA sequences for #AI eval. Experiments are underway at @StanfordBiochem @HHMI Janelia Research Campus.
Eterna@eternagame
Aug 6
Major props @DidiKieran @jgkoob @lemerleau @IIMCB_Poland @FrankRHutter @AF_Panescu @chaitjo @rishabh16_ for generating 600,000 sequences to fold into 1000 synthetic pseudoknots! The wet lab results will help these researchers improve their computational methods for RNA design.
12
1,982
RNA flexible? Maybe we can model that. First blind test of RNA 3D *ensemble* prediction — ligand-free SAMURI ribozyme (displayed on a group II intron scaffold) -- #MD and #deeplearning methods welcome, deadline Aug 22, 2026: predictioncenter.org/casp17/…
9
31
1,875
Das Lab retweeted
Eterna@eternagame
Jul 23
OpenKnot Round 9 features secondary structures designed by players to create compact, pseudoknotted RNA using 240 bases. GenAI teams also will test whether their methods perform as well as the expert players at a longer length. Check out the puzzle at: eternagame.org/labs/14343053
Screenshot of Eterna puzzle interface

ALT Screenshot of Eterna puzzle interface

6
2
12
2,801
Pseudoknots, AI, and preview of Eterna's first RNA replicase results at EternaCon 12, virtual on Sunday July 26, 2026! Preregister for free at: eternagame.org/eternacon/202…
2
7
1,138
Can humans+AI get 1M #cryoEM-able #RNA structures? Phase 1: humans design 1000 pseudoknot structures @eternagame by Jul 19. Phase 2: AIs design 1000 sequences for each by Jul 31. Come join! Latest phase of the OpenKnot challenge eternagame.org/challenges/11…
Eterna@eternagame
Jul 7
Eterna's newest puzzle challenges players to design 240-base RNA strands that will fold into compact pseudoknots. The puzzle provides a metric for counting the number of pairs that cross to form large, synthetic pseudoknots. Check out the puzzle at eternagame.org/labs/14333719
ZG_25 by Father_Z

ALT ZG_25 by Father_Z

1
2
9
2,122
Our lab is very honored to be recognized with Stanford's Open Science Champion Prize datascience.stanford.edu/cor… for efforts including @eternagame. Thanks for supporting an extraordinary community @StanfordData @StanfordHAI!

Stanford HAI

hai.stanford.edu
2
3
33
2,370
First AI-generated RNA with novel atomically ordered 3D fold! With @eternagame @StanfordBiochem @chaitjo @PossuHuangLab @UWproteindesign @ShujunHe0717 @navtejtoor @HHMIJanelia on bioRxiv doi.org/10.64898/2026.05.21.…
2
58
5
268
29,026
Third (& last?) intense week of #RNA server-only targets on #CASP17: small molecule binding ribozymes and aptamers & more group II introns in multiple states. Strange mix of natural and non-natural RNA and compounds and proteins. Looking forward to less crazy pace in next weeks.
3
12
799
The 2nd week of #CASP17 is closing, with more group II introns and some other RNAmake synthetic designs — monomer and dimer (!) targets for both. And more #RNA targets are coming in week 3: predictioncenter.org/news.cg…
2
5
686
Latest #CASP17 #RNA targets are a tiny aptamer for tryptophan selected by Yarus lab @cuboulder, a miniTTR by RNAmake @JosephYesselman, and two singlet glycine riboswitches discovered by @ronbreaker Strobel. Note that first one — a 25-nt RNA by #cryoEM? predictioncenter.org/casp17/…
4
11
1,005
First natural #RNA in #CASP17 is a group II self-splicing intron, and it’s also the season's 1st multistate target! Will server algorithms detect homologous group II intron structures to help modeling? Can servers model both unspliced and spliced states? predictioncenter.org/casp17/…
1
8
813
Two more #CASP17 #RNA targets: OpenKnot @eternagame molecule from AI designer gRNAde @chaitjo & triphosphorylating ribozyme selected by Muller lab @UCSanDiego. All 8 RNA targets are non-natural — how will modeling methods do without MSAs, templates, homologous training examples?
2
11
1,342
Next four #CASP17 #RNA targets are another @eternagame OpenKnot design and computational RNA designs from 3 distinct deep learning methods by @ShujunHe0717 @UWproteindesign! predictioncenter.org/casp17/…
3
11
1,095
First two targets in #CASP17 are #RNA, and they're designs from the online videogame @eternagame. Hope the bots preparing for CASP have been playing Eterna!
2
3
12
1,142
The 17th Critical Assessment of Structure Prediction #CASP17 begins tomorrow. 2 #RNA targets per day for next few weeks! >60 servers registered already, including @kaggle teams. Join the fun at predictioncenter.org/casp17/
1
6
9
981
Results are in for @StanfordMed @kaggle #RNA 3D Folding, Part 2! Top teams team_cp and AyPy together just outperform the best template oracle, another milestone in computational biology. Come join the conversation as we prepare for #CASP17: kaggle.com/c/stanford-rna-3d…
10
37
12,084
Best codes in Stanford @kaggle #RNA 3D Folding challenge are getting better after release of protenix-v1 @ai4s_protenix and RNApro @NvidiaHealth. No apparent impact from Agentic AI yet. Can any team or agent beat the best template oracle by March? kaggle.com/c/stanford-rna-3d…
4
15
1,612
Load more