@_kaiwenchen

Assistant Professor @NUSMedicine. Department of Microbiology and Immunology. Cell death. Innate immunity. Inflammation.

 Singapore
nus.edu.sg/lsi/principal-investigators/asst-prof-chen-kaiwen/
Joined August 2018
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For >10 years, neutrophils have challenged a central assumption of inflammasome biology by secreting IL-1 without robust pyroptosis. Our new study shows that the local inflammatory milieu regulates neutrophil susceptibility to CASP1-dependent pyroptosis. science.org/doi/10.1126/scia…

Threat assessment shapes neutrophil cell fate upon inflammasome activation

Inflammatory environment and TLR priming dictate neutrophil susceptibility to pyroptosis.

science.org
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Kaiwen Chen retweeted
Andre Samson@AndreSamson15Aug 28
Thrilled to share our work! science.org/doi/10.1126/scie… Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMRC #ScienceResearch

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to...

science.org
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Congratulations to our co-first authors See Jie Yow, Bing-Chen Wu, and Pung Hai Shin, and sincere thanks to all co-authors and collaborators for their contributions to this work!
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The RNA helicase DDX6 promotes immunosuppression in #cancer by repressing ADAR1-mediated #dsRNA stabilization, preventing interferon activation. Learn more in Science #Immunology: scim.ag/4eeZDga
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How lytic cell death drives autoantigen release and fuels inflammation? With @lynndustinlab we ask this using a common autoantigen, TRIM21. The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death | Science Immunology science.org/eprint/VEVN4EQK8…

The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death

TRIM21/Ro52 assembles proinflammatory immune complexes.

science.org
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TRIFosomes found😀. Very proud of our team’s work to identify endogenous TRIFosome. Surprisingly whilst TRIFosomes activate NFKB, IFN signaling is from monomeric or dimeric TRIF. doi.org/10.1126/sciadv.aeb95…

Toll-like receptor signaling outcome is determined by the stoichiometry of the endogenous TRIFosome

A previously entirely unknown mode of TLR signal transduction is elucidated.

science.org
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We are happy to announce that the first paper from the Najafov Lab has been published in @Nature! In this study, we identified SIGLEC12 as a mediator of plasma membrane rupture (PMR) for necroptotic cell death using a genome-wide CRISPR-based systematic approach. @UTSWMedCenter @UTSWScience @UTSWNews @UTSWInternalMed @CRI_UTSW #necroptosis #MLKL nature.com/articles/s41586-0…

SIGLEC12 mediates plasma membrane rupture during necroptotic cell death

Nature - CRISPR–Cas9-based genome-wide screening shows that SIGLEC12 mediates plasma membrane rupture in cells undergoing necroptosis, possibly through a human-specific mechanism, indicating...

nature.com
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New pre-print from the lab: Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer (NK) cells. biorxiv.org/content/10.1101/… @BiologyatYork @YBRI_UoY @The_MRC

Non-canonical inflammasome drives intrinsic anti-microbial responses in human Natural Killer cells

Inflammasomes are critical in rapidly responding to infections and tissue damage, with current paradigms centred on macrophages and epithelial cells. Natural Killer (NK) cells are innate lymphoid...

biorxiv.org
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Inflammatory signalling must eventually be turned off (e.g. by feedback inhibition) to prevent chronic inflammation. We didn't know how #inflammasomes turn off their signalling in vivo ... until now! (🧵: 1/3) shorturl.at/8lWxW
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Fantastic work by @inflammasomelab showing in vivo the importance of regulating caspase-1 activity in inflammatory conditions! Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven diseases biorxiv.org/content/10.1101/…

Caspase-1 self-terminates protease activity to enforce homeostasis and prevent inflammasome-driven...

Signal shutdown mechanisms must exist to silence the potent inflammatory programs initiated by the caspase-1 (CASP1) protease, to allow inflammation to resolve and reinstate tissue homeostasis. It is...

biorxiv.org
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🔥 Open postdoc position in human inflammation-driven control of infection! Join me at the University of Geneva, Switzerland this summer as I’m moving my Wellcome-funded research activity to the Department of Microbiology and Molecular Medicine! Please RT (1/5)
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Excited to share our latest paper: TLR4 endocytosis and endosomal TLR4 signaling are distinct and independent outcomes of TLR4 activation in @emboreports embopress.org/doi/full/10.10… #FrazerInstitute @UQMedicine @TRI_info
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I am excited to share that Michelle's (Hui Wen) PhD work on microbial subversion of innate immune and cell death pathways is now online! Congrats @michelleyeaphw and all co-authors! 🥳 embopress.org/doi/full/10.10…

A bacterial network of T3SS effectors counteracts host pro-inflammatory responses and cell death to...

The EMBO Journal - Innate immune signalling and cell death pathways are highly interconnected processes involving receptor-interacting protein kinases (RIPKs) as mediators of potent anti-microbial...

link.springer.com
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The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer science.org/doi/10.1126/scia…

TBK1 and IKKε prevent premature cell death by limiting the activity of both RIPK1 and NLRP3 death...

TBK1 and IKKe prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.

science.org
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We are excited to share a new paper from the lab - led by first author and @cwrumstp @cwrusom student Meghan O'Keefe. 1/n Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP: Cell Reports cell.com/cell-reports/fullte…

Restraint of inflammasome-driven cytokine responses through the mRNA stability protein TTP

O’Keefe et al. determined that inflammasome agonists, working through the mitochondria, rapidly inactivate ERK1/2. They further show that the ERK substrate, TTP, is also inactivated, leading to...

cell.com
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Kaiwen Chen retweeted
Yuan@Yuanqiao100227 Jan 2025
We have a fully funded PhD scholarship for Aug 2025 intake. If you are interested in joining our research group, please check the admission requirement on the website and contact us. ntu.edu.sg/education/graduat…

Doctor of Philosophy | Chemistry

A rigorous PhD programme in Chemistry combining advanced coursework with research experience. #2 in Asia and #8 in the world for Chemistry, according to the 2025 QS World University Rankings by...

ntu.edu.sg
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Thrilled to start 2025 with our latest findings! @fallfelfallen Yersinia invades macrophage cytosol to activate caspase-11 when caspase-8 or YopJ are inactive cell.com/cell-reports/fullte…

Plasticity of cell death pathways ensures GSDMD activation during Yersinia pseudotuberculosis...

Injection of YopJ by Yersinia pseudotuberculosis triggers RIPK1-dependent caspase-8 and GSDMD activation in murine macrophages; however, how macrophages defend against Yersinia when caspase-8 or YopJ...

cell.com
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In this study, Tye et al show how RIPK3-caspase-8 signaling induces inflammation to drive MAFLD, while MLKL noncanonically regulates lipid accumulation and metabolism to drive obesity and MAFLD. @_KateLawlor @CiiiD_Hudson @Hudson_Research @WEHI_research life-science-alliance.org/co…
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Hot off the press! 🔥 In our latest @NatureComms paper, we used in vivo imaging to track EV formation in the bone marrow microenvironment. We found that circulating EVs correlates with tissue damage caused by leukemias like AML! @WEHI_research @latrobe @AusCellDeathSoc
WEHI (Walter and Eliza Hall Institute)@WEHI_research28 Oct 2024
Researchers have made a critical discovery that could help develop a future blood test to potentially monitor the level of tissue damage in patients with diseases like #cancer. wehi.edu.au/news/cellular-co… 🧵1/2
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Kaiwen Chen retweeted
Broz Lab@broz_lab6 Jun 2023
🚨PhD position opening in our lab at the Department of Immunobiology (DIB) in Lausanne! We are searching for a curious and motivated PhD student to study #innateimmunity, #inflammasomes or #NINJ1-induced cell death. For details: tinyurl.com/PBDIB Please RT and/or apply!
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