Oxford
Joined March 2020
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How lytic cell death drives autoantigen release and fuels inflammation? With @lynndustinlab we ask this using a common autoantigen, TRIM21. The autoantigen TRIM21 assembles proinflammatory immune complexes after lytic cell death | Science Immunology science.org/eprint/VEVN4EQK8…
JelenaBezbradicaLab retweeted
A new PAMP, a new innate immunity principle and a new preclinical application. I am so pleased to share our study on STING activation mechanisms in health and disease. Led by the fantastic Stephanie Ragland, follow the summary below for all we learned.
cell.com/immunity/fulltext/S…
JelenaBezbradicaLab retweeted
I'm super proud that our work using iPSC-derived macrophages as a model for human inflammasome signalling is now online in @CellRepMethods @ChloeMck2022 These are a great cell model for studying therapeutically relevant inflammatory pathways! shorturl.at/50ss3
JelenaBezbradicaLab retweeted
Interferons in health and disease.
Check out this review by @Lo_Zanzi & Daniel Boehmer in @CellCellPress #AAI2026 hubs.li/Q04c5DJg0
JelenaBezbradicaLab retweeted
Calling all Inflammazoomers: after brilliant talks from Siddharth Balachandran, Marcus Taylor, Katia Cosentino and Tanita Wein (catch up on the Abcam Hub) this Thurs we have 2 more..... Rachel Lai and Jueqi Chen GMT 15:00+1
New from Clare Bryant and team. Characterisation of endogenous TRIFosome and how it dictates the outcome of TLR signalling. Beautiful work!
TRIFosomes found😀. Very proud of our team’s work to identify endogenous TRIFosome. Surprisingly whilst TRIFosomes activate NFKB, IFN signaling is from monomeric or dimeric TRIF. doi.org/10.1126/sciadv.aeb95…
JelenaBezbradicaLab retweeted
Hot off the biorxiv press! 🔥 @SamuelLaraR finds GBP5 enhances macrophage glycolysis via glucose uptake, GTPase activity dependent and as being cis-Golgi localised. Bonus finding, GBP5 is important for full M1 macrophage functionality.
biorxiv.org/content/10.64898…
JelenaBezbradicaLab retweeted
Next on Inflammazoom gasdermins with Katia Cosentino and Tanita Wein Monday at 1 GMT
Reminder: new #InflammaZoom free Webinar is today at 2 pm BST with James Murphy @pseudokinase from WEHI and Jonathan Maelfait from VIB Ghent. Register via Abcam link below. See you soon!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
JelenaBezbradicaLab retweeted
#WeekendRead! #ToSenseOrNotToSense! #MysterySolved! Berouti, Wagner, Carell, @v_hornung &co show @CellCellPress that RNase T2 & PLDs generate #TLR7 & 8 agonistic ligands only if RNA does not contains pseudouridines explaining avoidance of self RNA sensing sciencedirect.com/science/ar…
Looking forward to hosting James Murphy @pseudokinase and Jonathan Maelfait @InflamResCen as #InflammaZoom speakers on Monday October 20th. Register below via Abcam link for this free Webinar.
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
Do not miss this! #inflammazoom is back in October 🎉 with James Murphy from WEHI and Jonathan Maelfait from VIB Ghent we are back with some really 🔥 stories!
InflammaZoom is back on October 20. Tune in from 2:00 to 3:00 PM BST for a deep dive into innate immunity and inflammasome biology.
Hear from James Murphy (WEHI, Melbourne, Australia) and Jonathan Maelfait (VIB-UGent, Ghent, Belgium).
Register now: bit.ly/4iXGqjw
#InflammaZoom #innateimmunity #inflammasomebiology
JelenaBezbradicaLab retweeted
New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry jbc.org/article/S0021-9258%2…
JelenaBezbradicaLab retweeted
Delighted to share that our study with @bioagelabs NLRP3 inhibitors is now online @JExpMed ! Together with @Geyer_lab @benedicte_py and @Innate_immuno we characterise BAL-0028 and BAL-0598. Excited to see the new NLRP3 biology they will reveal!
#NLRP3 is a target for anti-inflammatory therapies & can be inhibited by the tool compound MCC950. Wilhelmsen, @Rebecca_Coll et al. characterize new small-molecule inhibitors, BAL-0028 & BAL-0598, that have a distinct mechanism of action & binding site. hubs.la/Q03GtbGx0
JelenaBezbradicaLab retweeted
Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
@harvardmed @BostonChildrens
royalsocietypublishing.org/d…
JelenaBezbradicaLab retweeted
Thanks for highlighting the preprint of our work, now online @CellCellPress authors.elsevier.com/sd/arti…
JelenaBezbradicaLab retweeted
📢 paper - a new class of RIPK1 inhibitors. Lots of with here, with structure of it bound to RIPK1, biochemistry and more! Was fun being part of this with Tate group and many others. pubs.acs.org/doi/10.1021/acs…
JelenaBezbradicaLab retweeted
Discovery of a pH sensor that regulates inflammation.
Zhou and Medzhitov provide a mechanistic tour-de-force in defining how BRD4 links changes in pH to inflammatory gene expression. Kudos to the authors on this exciting finding.
sciencedirect.com/science/ar…
JelenaBezbradicaLab retweeted
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10! authors.elsevier.com/a/1lS0g…