@AndreSamson15

Postdoctoral Scientist at the Walter and Eliza Hall Institute of Medical Research | Cell biology | Microscopy | Cell death

 Melbourne, Australia
Joined January 2021
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  • Following518
  • Followers409
2Media
Doctors @pseudokinase, @IBDmedicaldoc, @AndreSamson15 & @aysha_h_alani published findings in “Science” about a molecular defect happening very early in IBD progression that may help explain why flare-ups and disease relapse can occur. scitechdaily.com/scientists-…
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Thank you Ivan for this thoughtful Research Highlight in @cell_res on our recent @ScienceMagazine paper. Great read!
Ivan Zanoni
@Lo_ZanziOct 8
#NoTimeToDie! Happy to share my Research Highlight @cell_res about a new #necroptosis to #apoptosis axis predicting #IBD relapse recently published @ScienceMagazine by Murphy &co 👉 science.org/doi/10.1126/scie… nature.com/articles/s41422-0…

No time to die: cell death predicts IBD relapse

Cell Research - No time to die: cell death predicts IBD relapse

nature.com
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Thrilled to share our work! science.org/doi/10.1126/scie… Patients can look well-controlled and still have epithelial death programs running. We found it in nascent IBD lesions on advanced therapy and it flagged who relapsed over 2–3 years. @WEHI_research @NHMRC #ScienceResearch

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Although current therapies aim to...

science.org
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And big thanks to the whole team @WEHI_research @TheRMH including @pseudokinase @IBDmedicaldoc @aysha_h_alani the X-less Jiyi Pang, James Vince & Edwin Hawkins, the support from @NHMRC @KR_Foundation @crohnscolitisau, and to the patients with #IBD who were involved in this study
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Excited to see our work published in @ScienceMagazine. So proud of my PhD student @aysha_h_alani, co-first author. Incredible collaboration between @WEHI_research & @TheRMH —a step towards helping people with #IBD achieve more durable remission. #CrohnsDisease #UlcerativeColitis
WEHI (Walter and Eliza Hall Institute)@WEHI_researchAug 27
Uncovered: early molecular warning signs of inflammatory bowel disease reveal the condition can begin before symptoms appear and continue silently even when patients appear well. Published in @ScienceMagazine. 🔗wehi.edu.au/news/researchers…
Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"

ALT Image taken through spatial transcriptomics showing patterns of cell death-related genes in gut tissue from people with inflammatory bowel disease. The headline reads "The 'smouldering' defect behind inflammatory bowel disease flare-ups"

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Glad to share my cover art for the Feb 2025 issue of @TrendsBiochem. Check out our review in "Protein shapeshifting in necroptotic cell death signalling" with @pseudokinase @AndreSamson15 and Wayne Cawthorne cell.com/trends/biochemical-…
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I am looking for a research assistant to join my new lab in Melbourne, Australia at WEHI. Please apply at the link below! tinyurl.com/4wkt2jve
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I am looking for a postdoc to join my new team in Melbourne, Australia at WEHI to work on lung stem cells and disease, including lung cancers! International candidates+ those just finishing up PhDs welcomed Please apply below: tinyurl.com/54xsmc9e
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📢 Excited to see our Luminary, Prof James Murphy @pseudokinase as a newly appointed deputy director of @WEHI_research in 2025! His visionary leadership will shape the future of WEHI and continue to inspire the next generation of scientists🔬🚀 Read more: wehi.edu.au/news/new-scienti…

New scientific leadership team for WEHI

WEHI has appointed an outstanding scientific leadership team to drive impact, advance innovation and shape the future vision of the institute.

wehi.edu.au
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Intersted what happened after a cell dies by pyroptosis? 💀💥 We discovered something pretty cool - filopodia coverning pyroptotic macrophage to activate Clec9a on cDC - read Kate’s @inflammasomelab wonderful tweet👇including some awesome movies 🤩 @IMBatUQ @UQ_News
Inflammasome Lab@inflammasomelab9 Dec 2024
Have you ever wondered whether pyroptotic corpses have functions beyond the grave? We made the surprising discovery that pyroptotic corpses are flagged by #filopodia to alert #DendriticCells they need autopsy. A short Tweetorial (1/13)👇with movies! Link: rdcu.be/d2mjm
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Circulating extracellular vesicles betray damaged vessels at distal sites, as in acute myeloid leukaemia which damages bone marrow vasculature 📹 @SomeBlondeSci et al @WEHI_research in @NatureComms ➡️: buff.ly/3Z4IWxN with @Rooph
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Cold Spring Harbor Asia on Cell Death and Innate Immunity next year. See you in Suzhou, China!
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This study [link] shows how necroptotic effector MLKL can induce obesity and perturb lipid metabolism to drive MAFLD progression, independent of RIPK3 that regulates inflammatory events.@_KateLawlor @CiiiD_Hudson @Hudson_Research @WEHI_research hubs.la/Q02Y1rNf0
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Thrilled to have co-led this groundbreaking collaboration. @WEHI_research and @TheRMH are paving the way for new diagnostics and🎯 treatments, with the goal of improving lives for IBD patients globally. 🌏💪🤝 biorxiv.org/cgi/content/shor… @KR_Foundation @aysha_h_alani @AndreSamson15
James Murphy@pseudokinase13 Nov 2024
Check out our latest from @WEHI_research A joint effort with James Vince’s lab and our RMH colleagues. Super proud of this epic built on ~1100 western blots. Full credit to the leads, Jiyi Pang and Aysha Al-Ani, our collaborators, and my coconspirators including @AndreSamson15
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Very proud & excited to be socialising our preprint uncovering new mechanisms of epithelial cell death in IBD! Massive 4-year collab across @WEHI_research & @RMH. Big thanks to the patients involved in this study and support from @NHMRC & @KR_Foundation biorxiv.org/content/10.1101/…

A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to...

biorxiv.org
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Check out our new paper from the @_KateLawlor lab showing distinct roles for #necroptosis effectors RIPK3 (+ Caspase-8) that drives inflammation, and MLKL which regulates lipid handling in obesity-induced #MAFLD. @LSAjournal @CiiiD_Hudson @Hudson_Research life-science-alliance.org/co…

Divergent roles of RIPK3 and MLKL in high-fat diet–induced obesity and MAFLD in mice

Cell death frequently occurs in the pathogenesis of obesity and metabolic dysfunction–associated fatty liver disease (MAFLD). However, the exact contribution of core cell death machinery to disease...

life-science-alliance.org
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We are extremely grateful to @KR_Foundation for their support. Stay tuned for our exciting next instalment also in cahoots with @AndreSamson15 Aysha Al-Ani and Britt Christensen
Kenneth Rainin Foundation@KR_Foundation12 Nov 2024
A @WEHI_research study co-led by Innovator Award grantee Dr. James Murphy has introduced new methods for locating cell death in #IBD patients. We’re proud to support research like this that could lead to better diagnosis and personalized treatments. intelligenthealth.tech/2024/…
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Andre Samson retweeted
Cell@CellCellPress5 Nov 2024
Now online! Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair dlvr.it/TG1dnk
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Corning now offers sterile tips that come in a paper container, thus generating less plastic waste!
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Andre Samson retweeted
Pradeep R@pr4deepr25 Sep 2024
Gut Analysis Toolbox (GAT) is out on @J_Cell_Sci. A special moment as its my first senior author paper. Thanks to all the coauthors! especially @Dan_Poolio @sim_scientist @NikVeldhuis for their support & encouragement. @MIPS_Australia @WEHI_research doi.org/10.1242/jcs.261950

Gut Analysis Toolbox – automating quantitative analysis of enteric neurons

Summary: Gut Analysis Toolbox is a user-friendly image analysis tool for rapid and accurate characterization of neuronal distribution in 2D images of the gut wall, using custom-trained deep learning...

journals.biologists.com
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