Biochemist and Virologist. Currently challenging myself with a Molecular Microbiology PhD. * Fan of multichannel pipettes
Delft, Nederland
Joined October 2014
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Tomorrow 27th January, I will defend my PhD at TUDelft at 12 pm(GMT+1).
My PhD research, entitled “DISARMing viral invaders of bacteria”, has been supervised by @StanBrouns and @NobregaFL
Feel free to join the public defense lifestream:
collegerama.tudelft.nl/media…
#phd #defense
Cristian Aparicio-Maldonado retweeted
This is a macrophage REPAIRING A BROKEN BLOOD VESSEL
#MedTwitter #biology
Cristian Aparicio-Maldonado retweeted
Superb Postdoc position possibility with @RikkeMeyer5 at @iNANO_AarhusUni on investigation of the properties of secondary DNA structures in the extracellular matrix of bacterial biofilms
international.au.dk/about/pr…
Cristian Aparicio-Maldonado retweeted
Filamentous #phages have a low burden on bacteria and compensate by providing services that aid in the formation of better #biofilms , delivering toxins and other factors that increase #virulence, or modifying their behavior to pro…lnkd.in/dRybs5Nm lnkd.in/d7EN4jW7
Cristian Aparicio-Maldonado retweeted
Programazo el viernes en Toledo!!! Gracias @BeM_Toledo por organizar esta jornada tan interesante!!
El próximo viernes, 24 de junio, estaré en Toledo en la @uclm_es invitado por @BeM_Toledo presentando mi último libro #GenesDeColores publicado por @NextDoorPublish y también hablaré de #CRISPR en una charla del tema de mi libro anterior #EditandoGenes
@CNB_CSIC @CSIC
Cristian Aparicio-Maldonado retweeted
Congratualtions to my co-authors @_aparicioC @NobregaFL @StanBrouns @davidwtaylorjr. This was the first project I took on in the @davidwtaylorjr lab, and I'm really proud of the combination of cryo-EM, biochemistry and in vivo work we used to understand this fascinating system
Cristian Aparicio-Maldonado retweeted
Excited to share the final version of our DISARM story! How can bacterial confer incredibly broad antiphage immunity and yet avoid immunity? We think the answer may be due in part to DNA structural context and other mechanisms for cryptic specificity.
nature.com/articles/s41467-0…
Cristian Aparicio-Maldonado retweeted
Great work by my postdoc @jpkbravo @TexasScience and @_aparicioC and @NobregaFL out in @NatureComms! First exciting collaboration with @StanBrouns. Structure of a complex that can broadly DISARM phage by grabbing and reading ssDNA tails! nature.com/articles/s41467-0…
Cristian Aparicio-Maldonado retweeted
This project was initiated by the magnificent @BalwinaK who carried out most of the work with @Potoc_A. Also many thanks to all other co-authors: @SumanthMutte @_aparicioC @StanBrouns, Simon Lindhoud and Jacques Vervoort.
Thanks @NWO_Science and @ERC_Research for funding!
11/11
Cristian Aparicio-Maldonado retweeted
In eukaryotes, Argonautes (eAgos) are well known for their role in RNA-guided RNA interference.
Prokaryotes encode Agos (pAgos) but lack other RNAi components. Instead, certain 'long' pAgos use DNA guides to target and cleave invading DNA such as plasmids and viruses.
2/11
Cristian Aparicio-Maldonado retweeted
Very pleased to share our ✨New Paper✨ about an epigenetic conflict between a restriction–modification system and a methylation-dependent nuclease.
Want to know how that pans out? Continue reading here 🧵👇🏻 or head over to @NAR_Open for the full story: academic.oup.com/nar/advance…
Cristian Aparicio-Maldonado retweeted
.#Phagetherapy protocol approved: @PhageAustralia, a network of #phage researchers & clinicians, are excited 2 announce the approval of the STAMP phage therapy protocol, which regulates the process of phage therapy rather than a phage product specifically.
buff.ly/3K7t17r
Cristian Aparicio-Maldonado retweeted
New bioRxiv feature: in-line figures for everyone!
You can now print (or save as PDF) all articles with in-line figures, regardless of how the authors origiunally formatted them 1/n
Cristian Aparicio-Maldonado retweeted
A perfect mix of structure-guided biochemistry and in vivo experiments to determine how the DISARM immune system recognizes phage DNA!
1. I am delighted to be able to share our story on the enigmatic DISARM antiphage defence system, in collaboration with @davidwtaylorjr, @_aparicioC, @NobregaFL and @StanBrouns
biorxiv.org/content/10.1101/…
Cristian Aparicio-Maldonado retweeted
That’s what we proposed for DISARM - methyltransferase and nulease modules are clearly important yet DISARM still works if they’re not present. We speculated that other host methyltransferase and PLD nucleases can compensate, making those modules redundant
Cristian Aparicio-Maldonado retweeted
This is a first for me, a contaminant that turned my solid medium to liquid 😬🧫
ALT Petri dish containing liquid
Cristian Aparicio-Maldonado retweeted
Check out PhD student @ameliakschmidt's latest paper in collaboration with @theMaxwellLab out now @mbiojournal:
A Filamentous Bacteriophage Protein Inhibits Type IV Pili to Prevent Superinfection of Pseudomonas aeruginosa
doi.org/10.1128/mbio.02441-2…
Cristian Aparicio-Maldonado retweeted
Preprint by @_aparicioC ( @tudelft, Netherlands) and colleagues: Class I DISARM provides anti #phage and anti-conjugation activity by unmethylated DNA recognition.
buff.ly/3rpcFzl
