@ZlaticLab

Deciphering circuit mechanisms of learning and action-selection at @MRC_LMB

www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/marta-zlatic/
Joined December 2020
  • Tweets58
  • Following192
  • Followers392
3Media
Zlatic Lab retweeted
nature
@Nature13 Mar 2023
Scientists have generated the first complete map of the brain of a small insect. The map shows all 3,016 neurons and 548,000 synapses tightly packed in a young fruit fly's brain, which is smaller than a poppy seed go.nature.com/3ZTAU8q
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We’ve generated a synapse-resolution map of an insect brain, includes 3016 neurons and half a million synaptic sites! Out today in Science science.org/doi/10.1126/scie… Summary below and in @bpedigod’s thread. @ZlaticLab, @albertcardona, @neuro_data, Carey Priebe, and many others
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How does the brain work? 🧠 Today, scientists reveal the first complete brain wiring map in a relatively complex animal. The map can help understand how signals travel through the brain to drive behaviour and learning 👇 @PDN_Cambridge @CamZoology @MRC_LMB

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Zlatic Lab retweeted
Ben Pedigo@bpedigod10 Mar 2023
Our work studying the connectome of an insect brain, that of a Drosophila larva, is out today in Science! science.org/doi/10.1126/scie… Some highlights below and in @WindingMichael’s thread. Work with @neuro_data, Carey Priebe, @albertcardona, @ZlaticLab, and many others.
Diagram of network connectivity of a maggot brain, with neuron skeletons drawn on the border

ALT Diagram of network connectivity of a maggot brain, with neuron skeletons drawn on the border

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More coverage of @neuro_data and @ZlaticLab's groundbreaking work, out today in @ScienceMagazine.
NPR Health News
@NPRHealth9 Mar 2023
The first wiring map of an insect's brain hints at incredible complexity npr.org/sections/health-shot…
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ok. i've peaked. it's all downhill from here. i was interviewed as the "expert not involved in the study" by GIZMODO (!!😍!!) on the new larval connectome paper, out today in science from @albertcardona, @ZlaticLab, and colleagues. amazing work!! gizmodo.com/first-complete-m…

First Complete Map of a Fly Brain Has Uncanny Similarities to AI Neural Networks

Over 12 years, researchers mapped all of a larval fruit fly's brain, charting 3,016 neurons and 548,000 connections. It's big news for neuroscience.

gizmodo.com
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Zlatic Lab retweeted
FlyWire@FlyWireNews8 Feb 2023
Over 50,000 annotations have been added to the connectome by the FlyWire community! This APL neuron, tagged by @mwpleijzier @zhihaozheng, is 20x longer than a fly's whole body and is the longest cell in the brain. Proofread by labs of @gsxej @MurthyLab @sebastianseung
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Sneak peek: We will soon be releasing a complete insect brain connectome! With both brain hemispheres mapped, we can study how the left and right sides of the brain communicate #Drosophila #neuroscience
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Check out our new preprint: the complete #connectome of the entire #Drosophila larval brain, with all inputs and all outputs, and a comprehensive analysis of feedforward and feedback pathways across both brain hemispheres #Neuroscience biorxiv.org/content/10.1101/…
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What a great week of a lot of exciting science at the first in-person @MRC_LMB symposium since 2019. Congratulations to our postdoc @AutomneNine on being awarded the Joan Steitz Prize! So well-deserved George.
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Zlatic Lab retweeted
Pavan Ramdya@ramdya13 Sep 2022
Replying to @EPFL
@EPFL wrote a nice piece on our latest work developing tools to perform long-term / lifetime-scale recordings of ventral nerve cord motor circuits in behaving flies. Led by @LauraHrmns and @DrMuratKaynak jointly between my and @mssakar 's laboratories: actu.epfl.ch/news/a-window-i…

A window into the fruit fly's nervous system

Scientists at EPFL have developed an implantation technique that allows unprecedented optical access to the “spinal cord” of the fruit fly, Drosophila melanogaster. This work can potentially lead to...

actu.epfl.ch
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I love "navis"! Great python package with excellent tutorials to work with neuronal morphologies and connectomics data. I use this and "pymaid" (python-catmaid) extensively in my work. Blender support is a very nice perk too navis.readthedocs.io/ pymaid.readthedocs.io/
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Basal skin cells in zebrafish larvae can respond to electrical changes in their surroundings after an injury elifesciences.org/articles/6…
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Zlatic Lab retweeted
Hongjie Li@HongjieLi55 Jul 2021
Fly Cell Atlas is out!! check BioRxiv and flycellatlas.org; thanks everyone #FCAconsortium. biorxiv.org/content/10.1101/…
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Here is how @Merlin_Lange mounts samples in our standard multi-view light-sheet microscope: in addition to piezo actuators, we have 4 stages to move the objectives away from the sample holder. It looks scary to see objectives moving towards each other, but trust me it is safe! – at San Francisco, CA
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Zlatic Lab retweeted
Liam Drew@liamjdrew25 Feb 2021
The race to map every neuron and synapse in a brain bigger than a worm's is hotting up. Here's me looking at efforts to complete a fruit fly connectome and what it means for neuroscience. The Connected Connectome simonsfoundation.org/2021/02… via @SimonsFdn

The Connected Connectome

The most comprehensive wiring map to date of the fruit fly brain has transformed the field of neuroscience, identifying new cell types and reconfiguring circuit models. Are neuroscientists now ready...

simonsfoundation.org
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How does a cell division work? and what if it goes wrong? Check our short video for @EXPexpeditions for the #WorldCancerDay ⬇️⬇️⬇️
EXPeditions@joinExpeditions4 Feb 2021
"Cancer cells are selfish individuals that can grow anywhere." Explore Cancer Cells with @BaumBuzz from @MRC_LMB @Cambridge_Uni on EXP-Editions, the living library of knowledge. share.exp-editions.com/en_US… link to download the app in the comments #WorldCancerDay #cancerday
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Learning, predicting, & deciding are essential for survival across the animal kingdom, yet we know little about the rules that govern biological intelligence. Catch up with our lecture with Dr Marta Zlatic to explore the circuit basis of these behaviours. youtube.com/watch?v=4u-g8olq…

Biological intelligence: how we learn, predict and decide | The Royal Society

Learning, predicting, and deciding are fundamental brain functions ...

youtube.com
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Less than one week to go until our first seminar! Excited to see you there 🔬
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New preprint from the facility: A new Fiji and MATLAB toolbox for the projection of large 3D images on 2D planes: DProj = LocalZProjector (in Fiji) + DeProj (MATLAB) A quick thread⬇️ biorxiv.org/content/10.1101/…

DProj: A toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images

Background Quantitative imaging of epithelial tissues prompts for bioimage analysis tools that are widely applicable and accurate. In the case of imaging 3D tissues, a common post-processing step...

biorxiv.org
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