@ZlaticLab

Deciphering circuit mechanisms of learning and action-selection at @MRC_LMB

www2.mrc-lmb.cam.ac.uk/group-leaders/t-to-z/marta-zlatic/
Joined December 2020
  • Tweets58
  • Following192
  • Followers392
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👋 It is out! Our joint effort to create a complete synaptic connectome of Drosophila larval brain came true and is published in @ScienceMagazine: science.org/doi/10.1126/scie… Amazing work by @WindingMichael, @bpedigod + colleagues from @MRC_LMB @Cambridge_Uni @HopkinsEngineer @JHUBME

The connectome of an insect brain

A synaptic-resolution map of the neural circuits of a Drosophila larval brain reveals its connection types, neuron types, and circuit motifs.

science.org
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Zlatic Lab retweeted
nature
@Nature13 Mar 2023
Scientists have generated the first complete map of the brain of a small insect. The map shows all 3,016 neurons and 548,000 synapses tightly packed in a young fruit fly's brain, which is smaller than a poppy seed go.nature.com/3ZTAU8q
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We’ve generated a synapse-resolution map of an insect brain, includes 3016 neurons and half a million synaptic sites! Out today in Science science.org/doi/10.1126/scie… Summary below and in @bpedigod’s thread. @ZlaticLab, @albertcardona, @neuro_data, Carey Priebe, and many others
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How does the brain work? 🧠 Today, scientists reveal the first complete brain wiring map in a relatively complex animal. The map can help understand how signals travel through the brain to drive behaviour and learning 👇 @PDN_Cambridge @CamZoology @MRC_LMB

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Ben Pedigo@bpedigod10 Mar 2023
Our work studying the connectome of an insect brain, that of a Drosophila larva, is out today in Science! science.org/doi/10.1126/scie… Some highlights below and in @WindingMichael’s thread. Work with @neuro_data, Carey Priebe, @albertcardona, @ZlaticLab, and many others.
Diagram of network connectivity of a maggot brain, with neuron skeletons drawn on the border

ALT Diagram of network connectivity of a maggot brain, with neuron skeletons drawn on the border

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More coverage of @neuro_data and @ZlaticLab's groundbreaking work, out today in @ScienceMagazine.
NPR Health News
@NPRHealth9 Mar 2023
The first wiring map of an insect's brain hints at incredible complexity npr.org/sections/health-shot…
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ok. i've peaked. it's all downhill from here. i was interviewed as the "expert not involved in the study" by GIZMODO (!!😍!!) on the new larval connectome paper, out today in science from @albertcardona, @ZlaticLab, and colleagues. amazing work!! gizmodo.com/first-complete-m…

First Complete Map of a Fly Brain Has Uncanny Similarities to AI Neural Networks

Over 12 years, researchers mapped all of a larval fruit fly's brain, charting 3,016 neurons and 548,000 connections. It's big news for neuroscience.

gizmodo.com
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We would like to cordially thank to @albertcardona, Carey Priebe, @jovo, Volker Hartenstein, Richard Fetter and their labs and @HHMIJanelia for all the support on this journey 🙏
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The complete synaptic-resolution connectome comprises 3016 neurons and 548,000 synapses. We believe that this complete brain connectome will be a lasting reference study, providing a basis for a multitude of theoretical and experimental studies of brain function in general🧠
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Good luck @WindingMichael 🥳 We'll miss you...
Michael Winding@WindingMichael2 Mar 2023
I am starting my own research group at @TheCrick Institute in London! We will be investigating how neuronal circuits in the brain drive social interactions between animals. I have an immediate opening for a PhD student, apply by 22 March! crick.ac.uk/research/labs/mi…
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📢Did you know that we have developed a high throughput training system that allows real-time behaviour detection of freely moving larvae (up to 16) with targeted opto- and #thermogenetic stimulation of tracked animals in #Drosophila? elifesciences.org/articles/7… 1/3🧵
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2/3 This stimulation is delivered automatically with high temporal precision and is controlled in either open- or closed-loop. Using this approach, we show for the first time that Drosophila larvae can perform classical #conditioning with no overlap between sensory stimuli.
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3/3 In addition, our system will enable rapid screening for neurons and circuits that underpin different forms of learning and also has the potential to drive future research in larval taxis, decision-making, and spatial navigation and #memory.
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Zlatic Lab retweeted
FlyWire@FlyWireNews8 Feb 2023
Over 50,000 annotations have been added to the connectome by the FlyWire community! This APL neuron, tagged by @mwpleijzier @zhihaozheng, is 20x longer than a fly's whole body and is the longest cell in the brain. Proofread by labs of @gsxej @MurthyLab @sebastianseung
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Sneak peek: We will soon be releasing a complete insect brain connectome! With both brain hemispheres mapped, we can study how the left and right sides of the brain communicate #Drosophila #neuroscience
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👉 Our new preprint is out on #BioRxiv It is a comprehensive work between our lab, @albertcardona lab and our collaborators, with our talented postdoc @WindingMichael as a co-first author and also one of the coresponding authors 🥳
Michael Winding@WindingMichael28 Nov 2022
Check out our new preprint: the complete #connectome of the entire #Drosophila larval brain, with all inputs and all outputs, and a comprehensive analysis of feedforward and feedback pathways across both brain hemispheres #Neuroscience biorxiv.org/content/10.1101/…
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Check out our new preprint: the complete #connectome of the entire #Drosophila larval brain, with all inputs and all outputs, and a comprehensive analysis of feedforward and feedback pathways across both brain hemispheres #Neuroscience biorxiv.org/content/10.1101/…
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What a great week of a lot of exciting science at the first in-person @MRC_LMB symposium since 2019. Congratulations to our postdoc @AutomneNine on being awarded the Joan Steitz Prize! So well-deserved George.
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Zlatic Lab retweeted
Pavan Ramdya@ramdya13 Sep 2022
Replying to @EPFL
@EPFL wrote a nice piece on our latest work developing tools to perform long-term / lifetime-scale recordings of ventral nerve cord motor circuits in behaving flies. Led by @LauraHrmns and @DrMuratKaynak jointly between my and @mssakar 's laboratories: actu.epfl.ch/news/a-window-i…

A window into the fruit fly's nervous system

Scientists at EPFL have developed an implantation technique that allows unprecedented optical access to the “spinal cord” of the fruit fly, Drosophila melanogaster. This work can potentially lead to...

actu.epfl.ch
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