Assistant Professor @UTSWNephrology | Focusing on single cell analysis / epigenetics / metabolism, to identify therapeutic targets in kidney diseases
Dallas, TX
Joined May 2018
- Tweets313
- Following358
- Followers414
- Likes3.4K
Yoshiharu Muto retweeted
Polycystic kidney disease is the most common monogenic cause of kidney failure and affects over 10 million individuals. We've known most PKD is caused by mutations in PKD1 for over 30 years. But how PKD1 prevents disease has remained mysterious, limiting effective therapy.
Yoshiharu Muto retweeted
🧬 In #ADPKD, reduced PKD1 drives cyst growth and kidney failure.
We previously discovered a 55bp cis-repressive element in its 3'UTR.
We now identify the six critical bases—the miR-17 motif—whose disruption or masking restores PKD1 and slows disease.
🔗 biorxiv.org/content/10.1101/…
Yoshiharu Muto retweeted
Congratulations to @Yoshi_MutoLab and @hansul on their outstanding presentations today at the @UTSWMedCenter New Faculty Forum!
Yoshiharu Muto retweeted
Check out our latest manuscript where we generate a cross model single cell and spatial atlas of mouse PKD!
A cross model spatial and single-cell atlas reveals the conserved involvement of osteopontin in polycystic kidney disease | bioRxiv biorxiv.org/content/10.1101/…
Yoshiharu Muto retweeted
More to come if I ever learn the art of tweetorials.
For now, I'm so grateful to 1st author Vivian Huang @BIDMChealth and our collaborators from @harvardmed @HopkinsMedicine @YaleMed @UCSFMedicine @TuftsMedicalCtr @UW @BUMedicine...and @ScienceMagazine 🙏
Congrats to @samirparikhmd and team for a breakthrough paper in @ScienceMagazine showing that somatically acquired heteroplasmic mtDNA mutations are a cause of chronic kidney disease and are functionally reversible.
@ASNKidney @the_asci
👇👇
Yoshiharu Muto retweeted
Thrilled to share our work and truly honored to share senior autorship with @FabiolaTerzi ! Thanks @ScienceTM for publishing our work ! science.org/doi/10.1126/scit…
Yoshiharu Muto retweeted
Check out our new paper in Pediatric Nephrology assessing NAD Biosynthesis metabolites in pediatric AKI!
AKI is highly prevalent among hospitalized children, but there is no treatment. Read this Original Article on pediatric AKI associated w/impairment in nicotinamide adenine dinucleotide (NAD+) metabolism. @AmandaJClarkMD
link.springer.com/article/10…
Yoshiharu Muto retweeted
Novartis to acquire Regulus Therapeutics and farabursen, an investigational microRNA inhibitor to treat ADPKD, the most common genetic cause of renal failure finance.yahoo.com/news/novar…
Excited to share our latest review: "Single-cell epigenetics and multiomics analysis in kidney research", led by talented physician-scientist @hediseishi ! Grateful for the invitation and opportunity to contribute to the wonderful review series @CenJournal @jsnorjp
Yoshiharu Muto retweeted
New preprint alert! Endothelial oxygen sensing matters. Led by first authors Rajni Sharma and Ratnakar Tiwari, our new study shows that loss of PHD3 in endothelial cells fuels inflammation & fibrosis after AKI. biorxiv.org/content/10.1101/… @nu_fcvrri @NU_Nephrology
Yoshiharu Muto retweeted
#WhyScience Today, I am launching a 100-day Twitter/X campaign highlighting the importance of science, academia, and academic research in the U.S., with one tweet per day. Please help to increase visibility by liking, retweeting and adding to it.
Yoshiharu Muto retweeted
Bookending today’s medical grand rounds from @SonOfBarth for @UTSWInternalMed with @RonakLakhia1 delivering a cutting-edge lecture on new #ADPKD mechanisms for which she just commenced @NIDDKgov R01 funding
Congratulations Dr. Lakhia!!!
Yoshiharu Muto retweeted
Delighted to host @SonOfBarth Martin Pollak today and tomorrow for @UTSWNephrology and @UTSWInternalMed grand rounds.
Today’s talk laying out the genetic basis for defining structure-function in the podocyte resulting in FSGS
Yoshiharu Muto retweeted
Congrats @LabSouma ! Well deserved!
It was an amazing opportunity to see and talk with talented and wonderful people in the University of Oklahoma Nephrology! Thank you so much!! @Zimmermk1986 @OuhscN
Extremely excited to host @Yoshi_MutoLab from @UTSWNephrology @UTSWMedCenter for @OuhscN seminar series!
Yoshiharu Muto retweeted
Looking for some reading in the New Year? Our latest paper showing that HGF can create connection between epithelial tubules in vitro and in vivo. @CellUtsw @UTSWNephrology
pnas.org/doi/10.1073/pnas.24…
Yoshiharu Muto retweeted
I’m delighted to welcome aboard an extraordinary scientist, leader, and mentor to @UTSWNephrology faculty today:
Don Wesson’s community based research on nutrition and CKD brings his personal scientific journey from acidosis at the bench to the Dallas diaspora and beyond
Yoshiharu Muto retweeted
I am so excited to visit @UNCKidney @UNC_CBP.
Carl Gottschalk painstakingly demonstrated how urine can be concentrated relative to plasma. This is fundamental to terrestrial life
#countercurrent #nephtwitter
What an honor and privilege to be connected with Dr. Gottschalk!
Join us on Monday, Nov. 25th at 12:30 pm in MBRB G202 for the 24th Annual Gottschalk Lecture. @samirparikhmd will discuss how to turn back kidney frailty by targeting metabolism. @UNCKidney
Congrats @Vishal_D_Patel 🎊🎉🍾 Well deserved!!
Closing off #KidneyWk recognizing @Vishal_D_Patel who is receiving the ASN Distinguished Researcher Award. Congratulations! 🎉
